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A calcium sulfate-based, calcium sulfate hemihydrate technology, applied in the field of biomedicine, can solve the problems of limited application, easy formation of sinus and dead space, repeated infection, etc. long-lasting effect
Inactive Publication Date: 2009-07-22
TIANJIN UNIV
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[0004] However, only 25% of the gentamicin in Septopal can be released; in addition, the chain beads are easily surrounded by fibrous connective tissue, which further limits the release of antibiotics, so that the local antibiotic concentration cannot be achieved.
Since the PMMA chain beads cannot be degraded, the second operation will incise the beads, but this operation will bring great pain to the patient. After the chain is pulled out, there will be residual bone defects, and it is easy to form sinus tracts and dead spaces, which will lead to repeated infections.
Due to the above deficiencies, its clinical application is limited.
Method used
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example 1
[0027] Take 4g of PLGA, add it into 100ml of chloroform solution and stir, after it dissolves evenly, add 0.16g of gentamycin, continue to stir to form a uniform dispersion, then use a sprayer to prepare it into droplets, and after drying, it will become fine particles. After washing three times and vacuum drying, the PLGA microparticles loaded with gentamicin were prepared. The above-mentioned gentamicin can be replaced with leucomycin, vancomycin, tobramycin, cefuroxime and other antibiotics and pain relievers aspirin, ibuprofen, paracetamol and so on.
example 2
[0029] Take 3g of PLGA, add it into 100ml of chloroform solution and stir, after it dissolves evenly, add 0.6g leucomycin, continue to stir to form a uniform dispersion, emulsify the dispersion in the water phase medium to form small droplets, at 40°C, Continue to stir until the milk droplets harden into balls, filter, wash with ethanol several times, and dry in vacuum to obtain PLGA particles loaded with leumycin. The above leucomycin can be replaced by other antibiotics such as gentamicin, vancomycin, tobramycin, cefuroxime, and anticancer drugs cisplatin, melphalan, carmustine, doxorubicin, camptotheca base or paclitaxel etc.
example 3
[0031] Add 2g of chitosan, 1ml of glacial acetic acid, and 0.8g of vancomycin into 100ml of water, stir until it forms a uniform solution, then add 5g of calcium sulfate, mix well and set aside; under vigorous stirring, add it dropwise to disperse 0.5 In 30ml ethyl benzoate solution of mlspan-80, emulsify at room temperature for half an hour, add 0.2ml glutaraldehyde solution dropwise, continue to react for 1-2 hours, vacuum filter the product, wash with ethanol three times, and place in an electric drying oven Dry in medium to obtain vancomycin-loaded chitosan-calcium sulfate particles. The above vancomycin can be replaced by other antibiotics such as gentamicin, leucomycin, tobramycin, cefuroxime, and anticancer drugs cisplatin, melphalan, carmustine, doxorubicin, camptotheca Alkaline or paclitaxel, etc., painkillers such as aspirin, ibuprofen, paracetamol, etc.
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Abstract
The invention relates to a medicine-carried injectable calcium sulfate based slow-release implant composition and application thereof. The slow-release implant composition adopts a component A and a component B, wherein the component A comprises 100 portions of semi-hydrated sulfuric acid, 0.1 to 10 portions of nucleater, 0.1 to 5 portions of plasticizer, 0 to 5 portions of surfactant and 2 to 5 portions of medicine-carrying particles, and the medicine-containing mass concentration is between 4 and 20 percent; and the component B is a diluent, and the weight of the diluent is 30 to 60 portions as calculated by 100 portions of the semi-hydrated sulfuric acid. The medicine-carried particle injectable calcium sulfate based slow-release implant system has the advantages that: the slow-release implant system can inject local medicine-release implant into focuses and make the implant formed without operation, overcome the defect that general preformed implant materials do not closely contact circumferential bone tissues, and prevent encapsulation of fiber tissues; due to the osteoacusis function of calcium sulfate, the slow-release implant system is more suitable for growth and repair of the bone tissues; and due to unique medicine-carried particles, the slow-release implant system can realize local medicine release, is stable to release medicines, has long medicine effect time and high medicine utilization rate, and is suitable for treating bone defect and the like caused by osteomyelitis, osteocarcinoma and the like.
Description
technical field [0001] The invention belongs to the technical field of biomedicine, in particular to a drug-loaded injectable calcium sulfate-based slow-release implant component and its application. Background technique [0002] The repair and reconstruction of bone defects has always been one of the important research directions in surgery and related disciplines. Clinically, autologous bone and biomaterials are often used to repair bone defects, but they all need to be surgically implanted in the body, and even a second operation is required to remove the filling material, which brings great pain to the patient. In recent years, with the development of minimally invasive surgery, the research and application of injectable bone materials is becoming a new research hotspot. Currently, the injectable bone repair materials reported in the literature mainly include autologous bone marrow and its composites, bone cement, injectable calcium phosphate and other materials. [00...
Claims
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Application Information
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