Dripping pills of polygonum capitatum and its preparation process

A technology of Touhua and Liaodi Pills, which is applied in the fields of pill delivery, pharmaceutical formulations, and medical preparations containing active ingredients, etc. It can solve the problems that are not conducive to improving the ability of patients to seek medical treatment, the bioavailability of the first-pass effect of the liver and intestines, and the physical hazards of staff and other issues, to achieve the effect of being conducive to labor protection and environmental protection, improving bioavailability, and no dust pollution

Inactive Publication Date: 2006-02-08
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment
Furthermore, the production process of conventional oral preparations is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028] Now with several groups of specific examples, the preparation method of the Touhualiu dripping pills of the present invention will be further described.

[0029] [recipe selection]

[0030] 1. Raw materials: According to the method provided in [Preparation Method 1], the dry powder of the drug extract containing the active ingredients of the traditional Chinese medicine Cauliflower is pre-prepared for use;

[0031] 2. Single matrix: polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000 , Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac, etc.;

[0032] 3. Combination matrix: take g or kg as the unit, by weight, choose polyethylene glycol, polyoxyl 40 stearate, sodium carboxymethyl starch, beta cyclodextrin, Tween and other carriers for combination test;

[0033] 3.1 The combination of two different substrates: ta...

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PUM

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Abstract

The invention discloses a medicinal composition for heat clearing and detoxicating, especially a dripping pill of polygonum capitatum and its preparation process, wherein the dripping pill is prepared from polygonum capitatum, and medicinal carrying agent as the base material. The dripping pill has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, easy administering, and low price.

Description

technical field [0001] The present invention relates to a kind of medicine composition that has heat-clearing and detoxifying, diuretic and stranguria-relieving effects, and is used for the treatment of damp-heat stagnation, yellow-red urine, dripping and astringent pain, urinary tract infection, pyelitis, and the above-mentioned syndromes. An oral preparation of a pharmaceutical composition prepared from Polygonum japonica as a raw material. Background technique [0002] According to the ministerial drug standard WS 3 -Relinqing granule prepared by the preparation method given in B-3303-98 is a kind of heat-clearing and detoxifying, diuretic and dredging effect, which is used for damp-heat accumulation, yellow and red urine, dripping pain, urinary tract infection , pyelitis sees the oral granules for the treatment of the above-mentioned symptoms. After years of clinical verification, the curative effect is definite. It is a commonly used drug for clinical and family treatm...

Claims

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Application Information

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IPC IPC(8): A61K36/70A61K9/20A61P13/00A61P13/02
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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