Phenyl quinolines and their use as estrogenic agents

A technology of quinoline and phenyl, which is applied in the field of phenylquinoline compounds, can solve problems such as unexplained cell-specific effects of the same compound
CN1823046AInactive Publication Date: 2006-08-23WYETH LLC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WYETH LLC
Publication Date
2006-08-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention provides estrogen receptor modulators of formula: (I), having the structure wherein, R<1>, R<2>, R<3>, R<4>, R<5> and R<6> are as defined in the specification, or a N-oxide thereof or a pharmaceutically acceptable salt thereof or a prodrug thereof.
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Description

field of invention

[0001] The present invention relates to phenylquinoline compounds, their use as estrogenic agents and processes for their preparation. Background of the invention

[0002] The pleiotropic effects of estrogen in mammalian tissues have been well documented and estrogen is now recognized to affect many organ systems [Mendelsohn and Karas, New England Journal of Medicine 340:1801-1811 (1999), Epperson et al., Psychosomatic Medicine 61:676- 697 (1999), Crandall, Journal of Womens Health & Gender Based Medicine 8: 1155-1166 (1999), Monk and Brodaty, Dementia & Geriatric Cognitive Disorders 11: 1-10 (2000), Hurn and Macrae, Journal of Cerebral Blood Flow & Metabolism 20 (1-65: 2000), Calvin, Maturitas 34: 195-210 (2000), Finking et al., Zeitschrift fur Kardiologie 89: 442-453 (2000), Brincat, Maturitas 35: 107-117 (2000), Al-Azzawi, Postgraduate Medical Journal 77 : 292-304 (2001)]. Estrogen can affect tissue in several ways. The most typi...

Claims

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