Ghrelin analogs
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SOC DE CONSEILS DE RECH & DAPPLICATIONS SCI SAS
- Publication Date
- 2006-09-13
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
Background technique
[0001] The intermittent release of growth hormone from pituitary somatotroph cells is regulated by two hypothalamic neuropeptides, growth hormone releasing hormone and somatostatin. Growth hormone releasing hormone stimulates the release of growth hormone, whereas somatostatin inhibits growth hormone secretion (Frohman et al., Endocronol. Rev. 1986, 7, 223-253, and Strobi et al., Pharmacol. Rev. 1994, 46 , 1-34).
[0002] Growth hormone release from pituitary somatotroph cells can also be controlled by ghrelin. found that the hexyl peptide His-D-Trp-Ala-Trp-D-Phe-Lys-amide (GHRP-6) released growth hormone from somatotrops in a dose-dependent manner in several species including humans ( Bowers et al., Endocrinology 1984, 114, 1537-1545). Other potent growth hormone secretagogues, such as GHRP-1, GHRP-2 and hexarelin (Cheng et al., in Endocrinology 1989, 124, 2791- 2798; Bowers, C.Y. Novel GH-Releasing Peptides, In Molecular and Clinical Advances in Pitu...