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Preparation method of sodium danshensu

A technology of salvia miltiorrhiza and acidic water, which is applied in the field of preparation of danshensu sodium, can solve the problems of complex steps, large amount of organic solvent used, and small amount of preparation, and achieve the effect of simple process, no organic solvent residue, and controllable quality

Active Publication Date: 2006-11-29
SHANDONG LUYE PHARMA CO LTD
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AI Technical Summary

Problems solved by technology

[0007] Although there are above different preparation methods at present, method (1) has a small amount of preparation and high cost, and is not suitable for large-scale industrial production; method (2) has complicated steps and is difficult to control; although met

Method used

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Examples

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Example Embodiment

[0016] Preparation Example 1

[0017] Extract 50 kg of medicinal material Salvia miltiorrhiza with 1200L solution of 0.4% sodium hydroxide to obtain an extract containing Danshensu; the extract is adjusted to neutrality with hydrochloric acid, and is adsorbed with an adsorption column filled with weakly basic macroporous adsorption resin D301M. After the adsorbent is saturated, it is eluted with 400L of ethanol solution 50% (V / V), eluted with 0.4% (m / V) 500L of aqueous sodium hydroxide solution, collected the eluent, concentrated to about 20L, and adjusted to 20L with hydrochloric acid. The pH value is 2, and the adsorption column filled with the weak polar adsorbent AB-8 is used for adsorption under acidic conditions (pretreatment, the treated resin is eluted with hydrochloric acid solution until the pH value of the eluent is 2), and washed with 800 L of pure water. Remove, collect the eluate, and concentrate to obtain 2L of concentrated solution; add 500 g of sodium hydroxid...

Example Embodiment

[0018] Preparation Example 2

[0019] Extract 50 kg of medicinal material Salvia miltiorrhiza with 1200 L of 0.4% sodium hydroxide solution to obtain an extract containing Danshensu; the extract is adjusted to neutrality with hydrochloric acid, and adsorbed with an adsorption column filled with weakly basic macroporous adsorption resin D301R. After the adsorbent is saturated, eluted with 60% (V / V) 450L of ethanol solution, eluted with 0.5% (m / V) 600L of aqueous sodium hydroxide solution, collected the eluate, concentrated to about 10L, and adjusted to The pH value is 3, and the adsorption column filled with the weak polar adsorbent AB-8 is used for acid conditions (the treated resin is eluted with hydrochloric acid solution until the eluent pH value is 3) adsorption, and the hydrochloric acid aqueous solution is 0.2% (V / V ) 750L eluate, collect the eluent, concentrate to obtain 1.5L of concentrated solution; add 500 g of sodium hydroxide to the concentrated solution, cool, and...

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Abstract

A process for preparing the danshensu sodium from the alkaline liquid extract of red sage root includes such steps as adsorbing by weak-polarity resin, eluting, regulating pH value, acidic adsorbing by weak-polarity resin, eluting, concentrating, adding alkali, cooling, laying aside to obtain danshensu sodium crystals, filter, washing and drying.

Description

technical field [0001] The invention relates to a preparation method of danshensu sodium. Background technique [0002] Danshensu is a water-soluble component of the traditional Chinese medicine Danshen (Salvia miltiorrhiza Bge.), which has the functions of protecting myocardial ischemia / reperfusion injury, inhibiting platelet aggregation, anticoagulation, anti-inflammation, and enhancing body immunity [Zhou Maojin, Su Meiying, Liu Changxiao , Danshensu Research Progress, Chinese Herbal Medicine, Volume 34, No. 10, October 2003], its structure is β-(3,4-dihydroxyphenyl) lactic acid, because Danshensu is an unstable free acid, so It is often made into sodium salt when in use [Zhang Jingze, Jiang Hong, Liu Qingzeng, An overview of the chemical research of Danshensu, Tianjin Pharmacy, Volume 12, Issue 4, November 2000]. [0003] At present, the preparation methods commonly used to prepare high-purity danshensu sodium are: [0004] (1) Pan Jian et al. used preparative high-per...

Claims

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Application Information

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IPC IPC(8): C07C59/52C07C51/47
Inventor 马福禄刘广李桂生
Owner SHANDONG LUYE PHARMA CO LTD
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