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Use of chlorogenic acid in preparing medicine for improving immunity function

A technology of immune function and chlorogenic acid, applied in the field of chlorogenic acid, can solve problems that have not been reported

Inactive Publication Date: 2007-01-24
SICHUAN J Z BIO CHEM SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Nevertheless, we further found that it also has many other new medical effects through pharmacological experiments, and these new medical effects have never been reported in the existing literature.

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  • Use of chlorogenic acid in preparing medicine for improving immunity function
  • Use of chlorogenic acid in preparing medicine for improving immunity function

Examples

Experimental program
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Effect test

experiment example 1

[0010] Experimental Example 1 The effect of chlorogenic acid bulk drug on the phagocytosis of mouse peritoneal macrophages

[0011] 1 Experimental method

[0012] Kunming mice were randomly divided into 5 groups according to their gender and weight. Each mouse in the negative group was intraperitoneally injected with normal saline 0.4ml / 20g body weight, and each mouse in the positive group (mannan peptide) was given 0.025% mannan peptide 0.4ml / 20g body weight. (5mg / kg), the other three groups were injected with 0.4ml / 20g body weight (dose 20, 10 and 5mg / kg) by intraperitoneal injection of 0.1%, 0.05% and 0.025% chlorogenic acid bulk drug liquid respectively. All the above groups were administered once a day for 7 consecutive days, 30 minutes after the last administration, each mouse in each group was intraperitoneally injected with 1.0 ml of 5% chicken erythrocyte suspension. 6 hours after the injection, the mice were sacrificed by removing their cervical vertebrae, and 2 ml ...

experiment example 2

[0020] Experimental Example 2 The effect of chlorogenic acid bulk drug on the production of hemolysin used as immunogen in chicken erythrocytes

[0021] 1 Experimental method

[0022] The Kunming mice were divided into 6 groups according to their gender and body weight. Each group of mice was injected intraperitoneally with 0.2 ml of 5% chicken erythrocyte suspension for immunization. Cyclophosphamide group) each mouse was intraperitoneally injected with normal saline 0.4ml / 20g body weight, each mouse in mannan peptide group (positive control group) was given 0.025% mannan peptide solution 0.4ml / 20g body weight (dose is 5mg / kg) , chlorogenic acid raw materials were injected intraperitoneally with 0.4ml / 20g body weight (dose of 20, 10 and 5mg / kg) in the other three groups at concentrations of 0.1%, 0.05% and 0.025%, respectively. The above 6 groups were administered once a day for 7 consecutive days, but on the 4th day, except for the negative group, the mice in the other 5 gr...

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Abstract

The present invention discloses the use of chlorogenic acid in preparing medicine for raising immunological function alone or together with other medicine component.

Description

technical field [0001] The invention relates to a new use of chlorogenic acid, in particular to the use of chlorogenic acid in preparing a drug for increasing immune function. Background technique [0002] Chlorogenic acid widely exists in various medicinal plants such as honeysuckle, etc. At present, its chemical structure has been clearly studied. Some people have carried out medicinal research on it, and reported that chlorogenic acid can be used in the treatment of tumors and other diseases. Nevertheless, we have further discovered that it has many other new medical effects through pharmacological experiments, and these new medical effects have never been reported in the existing literature. SUMMARY OF THE INVENTION [0003] One object of the present invention is to provide the use of chlorogenic acid in the preparation of a drug for increasing immune function, wherein the immune function includes specific immune function and non-specific immune function. [0004] Aft...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61P37/04
Inventor 张洁包旭徐小平李鑫泉张舒张亮雍智全
Owner SICHUAN J Z BIO CHEM SCI & TECH DEV