Biomarkers for the efficacy of calcitonin and parathyroid hormone treatment

A parathyroid hormone, biomarker technology applied in the field of calcium-regulated gene expression profiling

Inactive Publication Date: 2007-01-31
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the potential effects of calcitonin on osteoblasts and its interaction with any other factors involved in bone metabolism are still debated

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0041] Salmon calcitonin and PTS893, a pharmacogenomic exploratory study in monkeys; microchip gene expression analysis

[0042] Foreword and brief introduction

[0043] The purpose of this example was to evaluate gene expression changes in cynomolgus monkeys after two weeks of subcutaneous treatment with 50 μg / animal / day of salmon calcitonin (sCT) and 5 μg / animal / day of PTS893 to elucidate the mediation of their effects mechanism of action and identification of therapeutically indicative biomarkers. This example is believed to be the first to comprehensively describe the molecular mechanism of action of salmon calcitonin and parathyroid hormone analogs by performing multi-organ gene profiling in primates. This example is also believed to be the first gene profiling analysis describing the molecular mechanism of action of hormone-mediated osteoconductive remodeling by salmon calcitonin and PTS893.

[0044] In this example, it was found that both salmon calcitonin and PTS893 ...

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PUM

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Abstract

A mufti-organ gene profiling analysis of the results of an administration to a subject of salmon calcitonin or a parathyroid hormone analogue provides biomarkers of calcitonin treatment efficacy and parathyroid hormone or parathyroid hormone analogue treatment efficacy. Among the biomarkers are the expression profiles of the genes for Y-box binding protein, BMPs, FGFs, IGFs, VEGF, &x3B1;-2-HS glycoprotein (AHSG), OSF, nuclear receptors (steroid / thyroid family) and others. The results obtained support the anabolic effect of salmon calcitonin on bone metabolism.

Description

field of invention [0001] The present invention relates generally to in vitro analytical testing of tissue samples, and more particularly to calcium-regulated gene expression profiling. Background of the invention [0002] Calcium is necessary for numerous cellular processes in the body and plays an important role in bone metabolism in particular. Calcium levels in the body are carefully maintained by the endocrine control system. Calcitonin and parathyroid hormone are two of this endocrine control system hormones. [0003] Calcitonin, a polypeptide hormone of approximately 32 amino acids, is an endogenous regulator of calcium homeostasis and is useful as an antiresorptive agent in the treatment of hypocalcemia-related disorders. Calcitonin is produced in thyroid parafollicular cells (C cells). A variety of calcitonins including, for example, salmon calcitonin and eel calcitonin are commercially available and are commonly used in the treatment of, for example, Paget's dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/23A61K38/29A61P19/08C12Q1/68
CPCA61K38/23C12Q1/6883A61K38/29C12Q2600/158C12Q2600/106C12Q2600/136A61P19/08A61P19/10
Inventor M·博巴迪拉
Owner NOVARTIS AG
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