Sustained release agent of curcumin and preparation method thereof

A technology of curcumin and sustained-release agent, which is applied in the field of curcumin sustained-release agent and its preparation, can solve the problems of low bioavailability of curcumin, achieve the effect of improving utilization and improving drug activity

Inactive Publication Date: 2007-05-30
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the bioavailability of

Method used

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  • Sustained release agent of curcumin and preparation method thereof
  • Sustained release agent of curcumin and preparation method thereof
  • Sustained release agent of curcumin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Get 1.034g (3mmol) curcumin (full name curcumin, be called for short Cur) dissolve in 30mL deionized water, adjust the pH value to be 10 with 2mol / L NaOH solution, obtain solution B; Take 1.53g (6mmol) Mg(NO 3 ) 2 ·6H 2 O and 0.75g (2mmol) Al(NO 3 ) 3 9H 2 O was dissolved in 10 mL of deionized water, and stirred to dissolve to obtain solution A. Under vigorous stirring, drop solution A into solution B, N 2 Protection, reaction at room temperature for 48h. The product was filtered, washed and dried in an oven. The deionized water used in the process is all deionized water with carbon dioxide removed.

[0050] The chemical analysis result of the curcumin sustained-release agent obtained at last is: Mg:Al:Cur=1.96:1:0.42. The specific chemical composition can be derived from the relationship between x, a, and b.

Embodiment 2

[0052] a. Take 0.594g (0.002mol) of Zn(NO 3 ) 2 ·6H 2 O and 0.375g (0.001mol) of Al(NO 3 ) 3 9H 2 O was dissolved in 100ml deionized water to make solution A;

[0053] b. Dissolve 4.8g of NaOH solid in 100ml of deionized water to form solution C;

[0054] c.N 2 Under protection, 10 parts by volume of solution A was added dropwise to 1 part by volume of solution C at a certain dropping rate, and the pH of the final solution was adjusted to be between 9 and 10, and stirring was continued for half an hour after the dropwise addition. After the obtained slurry was crystallized at 65°C for 18 hours, it was suction-filtered, washed with deionized water until neutral, dried at 65°C, ground, weighed, and stored in a desiccator.

[0055] d. Dissolve 1.034g (0.003mol) Cur in 300mL deionized water to obtain solution D;

[0056] e. the product of step c is dissolved in pure water, and it is prepared into a solution E with an Al ion concentration of 0.01mol / L;

[0057] f. Mix solu...

Embodiment 3

[0061] a. Take 1.485g (0.005mol) Zn(NO 3 ) 2 ·6H 2 O and 0.375gAl(NO 3 ) 3 9H 2 O (0.001mol) was dissolved in 100ml deionized water to make solution A;

[0062] b. Dissolve 4.8g of NaOH solid in 100ml of deionized water to form solution C;

[0063] c.N 2 Under protection, 10 parts by volume of solution A was added dropwise to 1 part by volume of solution C at a certain dropping rate, and the pH value of the final solution was adjusted to be between 9 and 10, and stirring was continued for half an hour after the dropwise addition. After the obtained slurry was crystallized at 65°C for 18 hours, it was suction-filtered, washed with deionized water until neutral, dried at 65°C, ground, weighed, and stored in a desiccator.

[0064] d. Dissolve 1.034g (0.003mol) Cur in 15mL deionized water to obtain solution D;

[0065] e. the product of step c is dissolved in pure water to be prepared as a solution E with an Al ion concentration of 0.1mol / L;

[0066] f. Mix solutions D an...

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Abstract

The invention relates to a curcumin slow release agent and process for preparation, wherein the slow release agent employs anion stratified material of hydrotalcite as the main body, the curcumin anion having a intercalation hydrotalcite crystal structure of the intercalation foreign body with a chemical constitution of (M2+)1-x(M3+)x(OH)2(Cur)a(Bn-)b*mH2O, wherein M2+ is one selcted from Mg2+, Zn2+, Cu2+, Ni2+, Co2+, Mn2+, M3+ is selected from Al3+, Fe3+ and Cr3+, Cur is intercalation foreign body, Bn-is the inorganic anion with n charges, 0 A61K 9/00 A61K 9/22 A61K 9/52 A61K 47/02 A61K 31/122 A61P 3/06 A61P 29/00 A61P 35/00 A61P 39/06 2 11 3 2006/11/29 1969815 2007/5/30 000000000 Zhejiang University of Technology 310014 Ni Zheming Wang Ligeng Xing Fangfang Pan Guoxiang huangmei juan yuanmu ji 33201 The Patent Agency of Zhejiang Engineering Institute On the Campus of Zhejiang Engineering Institute, District 6 of Zhaohui, the City of Hangzhou 310014

Description

(1) Technical field [0001] The invention relates to a curcumin slow-release agent and a preparation method thereof. (2) Background technology [0002] As a commonly used traditional Chinese medicine, curcumin has a wide range of pharmacological effects such as anti-inflammation, anti-tumor, anti-oxidation, and hypolipidemic, and its toxicity is very low, so it has a good prospect in clinical application. But curcumin is unstable in neutral medium and easy to degrade. Therefore, the bioavailability of curcumin in the body is very low. Therefore, improving its stability and bioavailability has become one of the hotspots in the study of such drugs. [0003] Curcumin has following equilibrium in alkaline solution, and formula (I) is divalent anion [0004] Formula (II) Formula (I) [0005] [0006] Dissolution Equilibrium of Curcumin in Alkaline Solution [0007] The interlayer anions of hydrotalcite are exchangeable, and its laminates contain strong basic sites, which c...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/22A61K9/52A61K47/02A61K31/122A61P3/06A61P29/00A61P35/00A61P39/06
Inventor 倪哲明王力耕邢方方潘国祥
Owner ZHEJIANG UNIV OF TECH
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