Method and apparatus for the production of lead 212 for medical use
a technology for radionuclides and lead 212, which is applied in the direction of solid sorbent liquid separation, component separation, separation process, etc., can solve the problems of not systematically guaranteeing the production of lead 212, and not being able to carry out true chemical purification of lead 212
Active Publication Date: 2018-07-10
ORANO MED
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Benefits of technology
The method ensures lead 212 with radiological and chemical purity of at least 99.95%, significantly reducing manual operations and contamination risks, while enabling faster production and automation in a closed system.
Problems solved by technology
However this method does not systematically guarantee the production of lead 212 with radiological purity consistently greater than 99.50%.
It also does not make it possible to carry out true chemical purification of the lead 212.
Method used
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Embodiment Construction
[0023]A first subject-matter of the invention is a method for producing lead 212 for medical use which comprises the production of lead 212 by the decay of radium 224 in a generator containing a solid medium to which radium 224 is bound, and the extraction of this lead from the generator in the form of an aqueous solution A1, and which is characterised in that it further comprises a radiological and chemical purification of the lead 212 contained in said aqueous solution A1 which is carried out by a liquid chromatography on a column.
[0024]Thus according to the invention, once extracted from the radium 224 generator, the lead 212 is subjected to a liquid chromatography on a column. This makes it possible to eliminate very efficiently both radiological and chemical impurities, which are extracted from the generator jointly with the lead 212, and therefore to obtain lead 212 presenting a radiological purity and a chemical purity that have never been achieved to date, or at least that h...
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Abstract
The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution A1, characterized in that the lead (212) contained in the aqueous solution A1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column. The invention also relates to an apparatus specially designed for automated implementation in a closed system of said method. It further relates to lead (212) produced by means of this method and this apparatus. Applications: manufacture of radiopharmaceuticals based on lead (212), useful in nuclear medicine for the treatment of cancers, particularly by a-radioimmunotherapy, or for medical imaging, in both humans and animals.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a U.S. national phase under the provisions of 35 U.S.C. § 371 of International Patent Application No. PCT / EP13 / 60672 filed May 23, 2013, which in turn claims priority of French Patent Application No. 1254798 filed May 24, 2012. The disclosures of such international patent application and French priority patent application are hereby incorporated herein by reference in their respective entireties, for all purposes.TECHNICAL FIELD[0002]This invention relates to the field of radionuclide production for medical use.[0003]More specifically it relates to a method for producing lead 212 that has a very high degree of radiological, chemical and even bacteriological purity, making it perfectly suited to medical use, as well as to an apparatus specially designed for automated implementation in a closed system of this method.[0004]It also relates to lead 212 produced by means of this method and this apparatus.[0005]Thus, the inve...
Claims
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IPC IPC(8): G21G1/00A61K51/12C22B13/02C22B13/06C22C11/00G21G4/08
CPCG21G1/0005A61K51/12C22B13/02C22C11/00C22B13/06G21G2001/0094G21G4/08B01D15/12B01D15/424G01N30/06G01N30/84G01N2030/067
Inventor TORGUE, JULIENMAQUAIRE, PATRICKYOUNG, JOHNANDREOLETTI, GILBERTBOURDET, PATRICK
Owner ORANO MED