Assessment of nerve fiber excitability

Abstract

A method for assessing nerve fiber excitability is disclosed. The method comprises: arranging an electrode in contact with skin of a person; determining a first and a second threshold value based on a stimulation current pulse of a first and a second waveform, respectively; wherein said determining of the first threshold value and said determining of the second threshold value each comprises: repeatedly providing a stimulation current pulse of the first or second waveform, respectively, through the electrode, wherein a stimulation current strength is altered between repetitions; and receiving signals from an interaction element with which the person interacts, said signals from the interaction element providing an indication of the first threshold value or the second threshold value, respectively, corresponding to a stimulation current strength necessary to be perceived by the person; and determining at least one measure of psychophysical perception based on the determined first and second threshold values.

Description

TECHNICAL FIELD[0001]The invention disclosed generally relates to determining a response to a stimulation of nerve fibers of a patient. In particular, the invention relates to a method and a system for assessment of nerve fiber excitability, and a control unit used in such a method.BACKGROUND[0002]Peripheral neuropathy is a condition, in which a large part of the peripheral nervous system or single peripheral nerves have been damaged. The condition causes suffering and disability for many patients and as the condition progresses it may cause chronic constant or cold evoked pain.[0003]Peripheral neuropathy may have several causes. For instance, small fiber neuropathy is frequent among many conditions, e.g. postherpetic neuralgia, impaired glucose intolerance, connective tissue disease, and diabetes mellitus. Peripheral neuropathy may also occur as a side effect of chemotherapy.[0004]The nervous system comprises several types of nerves, which are adapted to transmit signals relating t...

AI Technical Summary

Benefits of technology

This approach allows for a non-invasive, painless assessment of nerve fiber excitability, providing quantitative measurements less prone to subjective bias, enabling early diagnosis and monitoring of nerve degeneration and medication effects.

Problems solved by technology

The condition causes suffering and disability for many patients and as the condition progresses it may cause chronic constant or cold evoked pain.

Neuropathic pain is a clinical challenge regarding both diagnosis and treatment.

However, both nerve conduction studies and the threshold tracking method require direct measurements of nerve activity in that it requires an electrode to physically measure the signal transmitted in the nerve fiber.

Further, it may be difficult to perform in that the electrodes have to be located precisely onto either a sensory or a motor nerve, and the electrical stimulations are powerful and can be painful to the patient.

Therefore, the methods do not provide any insight to nerve fiber excitability of nociceptors, because the nociceptor activity cannot be recorded by the direct measurement.

This type of method only provides measures of the presence of the nerve fibers but may not provide insight to the properties of the nerve fiber membrane.

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