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Antifungal nail lacquer and method using same

a nail lacquer and antifungal technology, applied in the field of antifungal nail lacquer and method using same, can solve the problems of treatment failure and recurren

Inactive Publication Date: 2003-12-18
BENTLEY PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012] The present invention provides an antifungal nail lacquer composition which will provide clear, hard, films adherent to nail surfaces.
[0030] The invention also provides lacquer compositions effective for providing long-lasting, water-resistant adherent films on animal (e.g., human) skin and nails comprising a substantially non-aqueous solution of water-resistant, film-forming polymer, and plasticizing effective amount of at least one compound of formula (I).

Problems solved by technology

Thus, for example, onychomycosis serves as a reservoir for dermatophytes and contributes to treatment failure and recurrence of tinea pedis.

Method used

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  • Antifungal nail lacquer and method using same
  • Antifungal nail lacquer and method using same
  • Antifungal nail lacquer and method using same

Examples

Experimental program
Comparison scheme
Effect test

example 1-8

[0098] The nail lacquer compositions shown in the following Table were prepared. Each nail lacquer composition was applied to a glass substrate and allowed to dry in air for several hours and the state (homogeneity) of the dried lacquer films were observed. Visualization of crystals was by means of videomicrographs taken under crossed polarizers. The results are also reported in the following Table. Pentadecalactone used in these examples has the following structure:

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Abstract

A nail lacquer for the treatment or prevention of fungal infections, such as, onychomycosis, includes fungicidally effective amount of ciclopirox, econazole, or other antifungal agent in a compatible film-forming lacquer vehicle which includes a water-insoluble film-forming polymer; pentadecalactone, or similar cyclic lactone compound or derivative thereof, and volatile solvent. The pentadecalactone functions as a plasticizer for the film-forming polymer and as a penetration enhancer for the antifungal agent. The composition, when applied to the nails provides a hard, clear, water-resistant film containing the antifungal agent. The compositions are used for the treatment of onychomycosis.

Description

[0001] This application is a continuation of application Ser. No. 09 / 503,715, filed Feb. 14, 2000, (now allowed) and is incorporated, in its entirety, herein by reference.[0002] This invention relates to antifungal nail lacquer compositions useful in the treatment of onychomycoses or other fungal infestations affecting toe nails or finger nails using the nail lacquer composition. More particularly, the invention relates to antifungal nail lacquers which may be applied to nails to form films from which the antifungal agent will be released and become available for nail penetration; and to the method for treating or preventing fungal infestations of animal nails by applying the antifungal composition to the infected nail or to the fungal susceptible nail.STATE OF THE PRIOR ART[0003] Fungal infection of the nails, commonly referred to as onychomycosis, is most frequently caused by dermatophytes but also can be caused by molds and Candida. Mixed infections also occur. Onychomycosis incl...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/49A61K8/81A61K9/70A61K31/4174A61K31/4412A61K31/5375A61Q3/02
CPCA61K8/4973A61K8/8147A61K9/7015A61Q3/02A61K31/4412A61K31/5375A61K31/4174
Inventor SAMOUR, CARLOS M.
Owner BENTLEY PHARMA INC
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