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a technology of motoneuronotrophic factor and method, which is applied in the field of methods and use of motoneuronotrophic factor, can solve the problems that the cloned human mntf1 gene and its associated receptor have not yet been made publi
Inactive Publication Date: 2004-11-11
CHAU RAYMOND MING WAH
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Although various biological aspects of MNTF1 have been widely publicized in scientific journals, the DNA and inferred amino acid sequences of the cloned human MNTF1 gene and its associated receptor had not yet been made publicly available by Dr.
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[0037] The present invention comprises a family of neuronotrophic factors which possess the ability to exert a trophic effect on motoneurons and the genes which encode these factors. These factors have been isolated and the genes which encode these factors have been cloned and expressed, and both the nucleic acid and polypeptide sequences provided
[0038] It has been demonstrated that the isolated factors, the expressed, recombinant factors, and chemically synthesized polypeptide factors are capable of inducing the continued viability and neurite outgrowth of motoneurons. Therefore, these factors have been classified as "motoneuronotrophic factors" or "MNTFs."
[0039] MNTFs have been isolated from both rat and human sources and their biological activities have been examined both in vivo and in vitro. For example, their potential biological activity has been examined in both surgically-axotomized and hereditarily diseased animals.
[0040] The MNTFs disclosed in the present invention are us...
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Abstract
The invention is directed to a method of administering motoneuronotrophic factors for promoting the survival, growth, proliferation, or maintenance of neurons in an injured but not severed spinal cord. The method is useful for promoting axonal regeneration and for minimizing or inhibiting the effects of scar tissue formation or other elements that prevent nerve growth.
Description
[0001] This application is a divisional application directed solely to subject matter described and claimed in the original application of U.S. patent application Ser. No. 09 / 989,481, filed Nov. 20, 2001, by Raymond Ming Wah Chau, entitled "Methods and Use of Motoneuronotrophic Factors", which is a continuation of U.S. patent application Ser. No. 09 / 592,018, filed Jun. 12, 2000, by Raymond Ming Wah Chau, entitled "Isolation and Use of Motoneuronotrophic Factors;" which is a continuation of U.S. patent application Ser. No. 08 / 928,862, filed Sep. 12, 1997, by Raymond Ming Wah Chau, entitled "Isolation and Use of Motoneuronotrophic Factors;" which is a continuation-in-part of U.S. patent application Ser. No. 08 / 751,225, filed Nov. 15, 1996, by Raymond Ming Wah Chau, entitled "Motoneuronotrophic Factors," now abandoned; which is a continuation in part of U.S. provisional patent application 60 / 026,792, by Raymond Ming Wah Chau, filed on Sep. 27, 1996, now abandoned; which are hereby inco...
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Patent Type & Authority Applications(United States)
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