Stabilizers for polymerizable biocompatible materials

a biocompatible material, stabilizer technology, applied in the direction of plastic/resin/waxes insulators, impression caps, dental prosthetics, etc., can solve the problems of premature polymerization, metal salts, ascorbates, etc., to increase the flexibility of the final product and facilitate processing

Inactive Publication Date: 2005-09-15
ORTHOVITA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0036] Plasticizers may be added to the composition to facilitate processing and increase the flexibility of the final product. Examples of plasticizers include TEGDMA, hydroxyethyl methacrylate (HEMA), and phthalates such as diethyl phthalate, benzylbutyl phthalate, dibutyl phthalate, and dibenzyl phthalate.

Problems solved by technology

In general, however, the materials that are added to the composition to initiate polymerization under room temperature conditions, such as peroxides, photoinitiators, other free radical generators (azo compounds, persulfates, phosphines, etc.), and certain reducing agents (amines, ascorbates, metal salts, etc.) can prematurely initiate polymerization.
Decomposition can result if the materials are stored too long or exposed to heat and / or light.
However, oxidation of the accelerating agents decreases the efficiency of the system and ultimately can result in the failure of the system to polymerize upon mixing.
Unfortunately, the addition of most commercial antioxidants will further inhibit polymerization.
Hallock does not teach the use of these amino acids alone or without the aid of hydrotalcite to stabilize polymerizable materials.
However, it is not used to stabilize and prolong the shelf life of a polymerizable system.

Method used

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  • Stabilizers for polymerizable biocompatible materials
  • Stabilizers for polymerizable biocompatible materials

Examples

Experimental program
Comparison scheme
Effect test

example 2

[0051] An L-cysteine salt solution was prepared and sprayed onto two batches of untreated fillers. One batch was then silanated and mixed with resin to form a stabilized paste; the other batch was mixed directly (without silanation) with resin to form a stabilized paste.

example 3

[0052] 1% and 0.5% of L-cysteine stabilizer was added to A resin. Control resin without the addition of stabilizer was also prepared. Set-time and temperature upon cure were measured at time, t=0, t=10 days, t=45 days, and t=70 days for both the stabilized materials and the control. Results indicate that the addition of the L-cysteine inhibited auto polymerization of the samples under 45° C. storage as compared to control samples—one of which polymerized after 20 days (FIG. 1). In addition, the L-cysteine containing samples did not inhibit polymerization upon mixing with a peroxide containing resin. In general, the set-time of the stabilized samples remained below 200 seconds for 50 days when stored at 45° C., which compares favorably to control samples that required refrigeration to achieve the same effect.

[0053] B) The utilization of stabilized accelerator containing resin in the preparation of composite paste also demonstrated maintenance of the set-time and reaction temperature...

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Abstract

The present invention provides polymerizable biocompatible materials stabilized by amino acids or reducing salts to improve shelf life. Methods of stabilizing a polymerizable biocompatible material are also provided that inhibit auto polmerization of the material over time.

Description

FIELD OF THE INVENTION [0001] The present invention relates to stabilizers for polymerizable biocompatible materials and polymerizable biocompatible materials with stabilizing amounts of amino acids or reducing salts. Also provided are methods of stabilizing such materials. BACKGROUND OF THE INVENTION [0002] The need for biomaterials in orthopaedic and dental applications has increased as the world population ages. A significant amount of research into biomaterials for orthopaedic and dental uses has attempted to address the functional criteria for orthopaedic and dental reconstruction within the human body. Biomaterials useful for orthopaedic and dental reconstructions must have high strength, must be able to be immediately affixed to the situs for reconstruction, must bond strongly to bone, and must give rise to strong, highly resilient restorations. [0003] Among the materials used for orthopaedic and dental restorative purposes are bone cements based upon acrylic species such as ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K6/884C08L63/00
CPCC08K5/175
Inventor POMRINK, GREGORY J.
Owner ORTHOVITA INC
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