Prevention and reduction of blood loss

a technology of blood loss and prevention, applied in the direction of cardiovascular disorders, peptides, drug compositions, etc., can solve the problems of contact activation, perioperative blood loss, etc., and achieve the effects of preventing or reducing the onset of systemic inflammatory response, and preventing or reducing ischemia
US20060194727A1Inactive Publication Date: 2006-08-31DYAX CORP
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
DYAX CORP
Publication Date
2006-08-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

Methods are described for preventing or reducing ischemia and / or systemic inflammatory response in a patient such as perioperative blood loss and / or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting and other surgical procedures, especially when such procedures involve extra-corporeal circulation, such as cardiopulmonary bypass.
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Description

RELATED APPLICATION

[0001] This application claims the benefit of U.S. application Ser. No. 10 / 456,986, filed Jun. 6, 2003, which claims the benefit from U.S. Provisional Application No. 60 / 387,239, filed Jun. 7, 2002, and U.S. Provisional Application No. 60 / 407,003, filed Aug. 28, 2002.

[0002] The entire teachings of the above applications are incorporated herein by reference.BACKGROUND OF THE INVENTION

[0003] Proteases are involved in a broad range of biological pathways. In particular, serine proteases such as kallikrein, plasmin, elastase, urokinase plasminogen activator, thrombin, human lipoprotein-associated coagulation inhibitor, and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa have been implicated in pathways affecting blood flow, e.g., general and focal ischemia, tumor invasion, fibrinolysis, perioperative blood loss, and inflammation. Inhibitors of specific serine proteases, therefore, have received attention as potential drug targets for various ischem...

Claims

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