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Compressible intravascular embolization particles and related methods and delivery systems

a technology of intravascular embolization and compression particles, which is applied in the field of compression particles, can solve the problems of inadvertent downstream embolization, poor positioning control, and perforation of blood vessels

Inactive Publication Date: 2008-02-07
BIOSPHERE MEDICAL INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0006] The invention includes compressible substantially spherical, porous embolization particles. The interior porous extend to the particle surface to form an exterior layer having exterior pores. The compressible embolization particle preferably has a diamete

Problems solved by technology

Disadvantages relating to the known methods include recanalization, perforation of blood vessels, inadvertent downstream embolization due to fragmentation or release of trapped particles, poor positioning control, instability, imprecise sizing, and shrinkage or movement of the embolic material.
Disadvantages of these particles include their non-precise size (aspect ratios) and open edges on the particles that cause them to clump together and subsequently plug up delivery catheters.
However, spherical embolization particles have several disadvantages.

Method used

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  • Compressible intravascular embolization particles and related methods and delivery systems
  • Compressible intravascular embolization particles and related methods and delivery systems
  • Compressible intravascular embolization particles and related methods and delivery systems

Examples

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Effect test

example 1

[0070] A crosslinked PVA embolization particle was prepared in the following manner. A mixture of 26.2 grams of PVA and 98.9 grams of deionized water was rapidly heated to 100° C. and held for 12 minutes. Subsequently, 39.9 grams of the resulting PVA solution was transferred for reaction purposes into a reaction kettle (a glass beaker) and set aside and allowed to cool. Separately, a mixture of 15 grams of rice starch and 135 grams of deionized water was heated to 80° C. and then 9.5 grams of the material was added to the PVA solution and thoroughly mixed. To this resulting mixture was added 3.6 grams of concentrated hydrochloric acid and 6.4 grams of about 37% formaldehyde (formalin solution) to form the reaction solution.

[0071] The reaction solution was then placed in a 2 liter glass reaction kettle and mixed at about 7000 rpm with a high-speed mixer having a high-speed air motor and using a mixing blade to whip air into the mixture until the foam stopped expanding and the result...

example 2

[0074] The same procedure performed in Example 1 was repeated, but the formaldehyde additive was reduced to 5.2 grams. It was believed that the reduction in formaldehyde would change the pot-life of the reaction solution, wherein “pot-life” is intended to mean the useful life of the mixture (after some period of time, the mixture ages to the point that it cannot be used to create a particle of the present invention). However, no significant change in pot-life was observed.

example 3

[0075] The same procedure performed in Example 1 was repeated, but the hydrochloric acid additive was reduced to 5.0 grams. The resulting sponges had both an increased firmness and increased resilience in comparison to the sponges produced in Example 1, wherein firmness is a qualitative measure of the compressibility of the particle. Further, the pot-life of the reaction material was decreased by about 30 seconds.

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Abstract

The present invention relates to substantially compressible, spherical porous embolization particles, including methods of making and using the particles. Further, the invention relates to embolization delivery systems for the introduction of the particle into the vascular luer.

Description

FIELD OF THE INVENTION [0001] The present invention relates to compressible embolization particles, including supplemental embolization particles, methods of making and using the particles, and delivery systems for delivery of the particles. BACKGROUND OF THE INVENTION [0002] Some intravascular interventional procedures produce an artificial embolism in mammals that is useful in controlling internal bleeding, blocking the blood supply to tumors, or relieving pressure in a vessel wall near an aneurysm. Known methods for producing an artificial embolism include use of (1) inflatable and detachable balloons, (2) coagulating substances, (3) later-curing polymeric substances, (4) occlusive wire coils, (5) embolization particles, and (6) supplemental occlusive embolic materials. Disadvantages relating to the known methods include recanalization, perforation of blood vessels, inadvertent downstream embolization due to fragmentation or release of trapped particles, poor positioning control,...

Claims

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Application Information

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IPC IPC(8): A61M5/00A61K9/14
CPCA61L24/0036A61B17/1219A61L24/06C08L29/04A61L2430/36
Inventor MATSON, LOUIS R.MCNAMARA, GERALD R.BRANDOM, DONALD K.
Owner BIOSPHERE MEDICAL INC
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