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Pharmaceutical compositions

a technology of pharmaceutical compositions and compositions, applied in the direction of aerosol delivery, immunological disorders, metabolism disorders, etc., can solve the problem of fast uptak

Inactive Publication Date: 2008-03-20
GW PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0015] The applicants have discovered that an alternative mode of administration allows the clinical or medicinal effects of cannabis to be maximised, whilst reducing the above discussed unpleasant and negative side effects. According to the present invention, the cannabis is formulated for sublingual delivery in aerosol or spray form, which offers unexpected advantages over known modes of cannabis delivery. The invention also relates to a device for delivering such a composition as an aerosol or spray.

Problems solved by technology

It is known that sublingual delivery of a pharmaceutically active agent results in fast uptake.

Method used

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Examples

Experimental program
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Effect test

example 1

[0112] A composition comprising delta-9-tetrahydrocannabinol (delta-9-THC) with HFC134a suitable for use in a device as described above can be formulated from the following ingredients:

Componentpercent w / wg / canDelta-9-THC0.70.099Ethanol 96% BP13.21.866Peppermint oil1.40.205HFC-134a84.712.02Total10014.19

[0113] The peppermint oil is added to the delta-9-THC / ethanol solution and mixed thoroughly. 2.17 g of the resulting solution is then placed in the canister 2 and the valve assembly, comprising the valve body moulding 4, first sealing washer 11, second sealing washer 13, spring 22, tube 23, and annular seal 10 are then sealed onto the canister 2 as shown in FIG. 1 by the cap 3. The propellant is then added to the canister by being forced through the valve core 14 at great pressure, and the complete device is then checked for leaks.

example 2

[0114] A second composition comprising delta-9-THC with HFC-134a suitable for use in a device as described above can be formulated from the following ingredients:

Componentpercent w / wg / canDelta-9-THC0.1640.010Ethanol 96% BP4.9920.305HFC-134a94.8445.795Total1006.11

[0115] The delta-9-THC is dissolved in the ethanol in the proportions set out above and 0.315 g of the resulting solution is then placed in a canister 2 and a valve assembly, comprising a valve body moulding 4, first sealing washer 11, second sealing washer 13, spring 22, tube 23, and annular seal 10, is then sealed onto the canister 2 by crimping as shown in FIG. 1 by the cap 3. The propellant (HFC-134a) is then added to the canister, by being forced through the valve ore 14 at great pressure, and the complete device is then checked for leaks. After the propellant entered the canister it dissolves the remaining portions of the composition.

example 3

[0116] A third composition comprising delta-9-THC and suitable for use in a device as described above can be formulated from the following ingredients:

Componentpercent w / wg / canDelta-9-THC0.1640.010Ethanol 96% BP7.50.458HFC-134a92.3365.641Total1006.11

[0117] The delta-9-THC is dissolved in the ethanol in the proportions set out above and 0.315 g of the resulting solution is then placed in a canister 2. A valve assembly (as described in Example 2) is then sealed onto the canister 2 by crimping and the HFC-134a propellant is then added to the canister, by being forced through the valve core 14 at great pressure, and the complete device is then checked for leaks. After the propellant entered the canister it dissolves the remaining portions of the composition.

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Abstract

The present invention relates to an improved mode of administration for cannabis and its natural and synthetic derivatives. A pharmaceutical composition suitable for sublingual aerosol or spray delivery of cannabis is provided. The formulation may be dispensed using a pump spray or the formulation may include a propellant, such as butane, 1,1,1,2-tetrafluoroethane (HFC-134a) or 1,1,1,2,3,3,3-heptafluoropropane (HFC-227). The term cannabis is used herein to refer to all physiologically active substances derived from the cannabis family of plants and synthetic cannabis analogues and derivatives, precursors, metabolites etc., or related substances having cannabis-like physiological effects.

Description

RELATED APPLICATIONS [0001] This application is a division of U.S. patent application Ser. No. 10 / 221,066, filed May 6, 2003, currently pending, which is a national stage filing under 35 U.S.C. §371 of international application PCT / GB01 / 01027, filed Mar. 9, 2001, which was published under PCT Article 21(2) in English, all of which are incorporated herein by reference.FIELD OF THE INVENTION [0002] The present invention relates to an improved mode of administration for cannabis and its natural and synthetic derivatives. The term cannabis is used herein to refer to all physiologically active substances derived from the cannabis family of plants and synthetic cannabis analogues and derivatives, precursors, metabolites etc., or related substances having cannabis-like physiological effects. BACKGROUND OF THE INVENTION [0003] The medicinal and psychoactive properties of the cannabis plant have been known for centuries. At present, cannabis is not legally available. However, there is growin...

Claims

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Application Information

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IPC IPC(8): A61J7/00B65D83/38A61K9/00A61K9/12A61K31/352A61K31/353A61K36/00A61K36/18A61K36/185A61K47/06A61K47/08A61K47/10A61K47/12A61K47/14A61K47/20A61K47/22A61K47/24A61K47/26A61K47/34A61M11/00A61P1/08A61P1/12A61P1/14A61P19/02A61P21/02A61P25/02A61P25/04A61P25/06A61P25/08A61P25/20A61P27/06A61P29/00A61P31/18A61P35/00
CPCA61K9/006A61K36/185A61K31/352B65D83/44A61P1/08A61P1/12A61P1/14A61P19/02A61P21/02A61P25/00A61P25/02A61P25/04A61P25/06A61P25/08A61P25/20A61P27/06A61P29/00A61P3/00A61P31/18A61P35/00A61P37/00A61K9/12
Inventor ROSS, CALVIN
Owner GW PHARMA LTD
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