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Singlec-9 binding agents

a single-molecule, binding agent technology, applied in the direction of antibody medical ingredients, instruments, peptide/protein ingredients, etc., can solve the problems of anaemia, infection and bleeding, and achieve the effect of facilitating identification and/or diagnosis, effective drug targets, and significantly lower levels of cell-free siglec-9

Inactive Publication Date: 2009-09-03
UNIV COURT OF THE UNIV OF DUNDEE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a use of sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) binding agents for the manufacture of a medicament for the treatment of cell proliferation and differentiation disorders. These binding agents can be used to treat diseases such as cancer, particularly those involving the monocytic and myeloid lineages, by targeting cells that express Siglec-9. The binding agents can be antibodies or fragments thereof that retain the ability to bind to Siglec-9. The antibodies can be derived from various species, including humans, and can be modified for improved binding specificity or function. The binding agents can modulate the activity of Siglec-9 and affect the proliferative and differentiative state of cells."

Problems solved by technology

The loss of red blood cells may lead to complications such as anaemia, infection and bleeding.

Method used

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Examples

Experimental program
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Embodiment Construction

[0067]The present invention will now be described further by way of example and with reference to the Figures which show:

[0068]FIG. 1. Expression of CD33-related Siglecs on AML cells. Mononuclear AML bone marrow cells from sample XXI (see Table 2) were stained with anti-CD33-biotin mAb and the indicated FITC-labelled anti-Siglec mabs, followed by streptavidin-APC and analysed by flow cytometry. The non-viable cells labelled with 7-AAD were not included in the analyses. The left quadrants were set to include more than 99% of cells labelled by the isotype control. The percentages of CD33+ / Siglec+ cells are shown.

[0069]FIG. 2. Co-expression of Siglec-7 and Siglec-5 on the Siglec-9-positive subset of AML cells. Mononuclear AML bone marrow cells from samples I (top panels) and XXI (lower panels) (see Table 2) were stained with anti-Siglec-9-FITC mAb and either anti-Siglec-5-biotin or anti-Siglec-7-biotin mAbs, followed by streptavidin-APC and analysed by flow cytometry.

[0070]FIG. 3. Phen...

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Abstract

The present invention relates to agents capable of binding sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) and their use in the treatment of cell proliferation and differentiation disorders. Furthermore, the present invention provides associated pharmaceutical formulations and methods.

Description

FIELD OF THE INVENTION[0001]The present invention relates to agents which bind the cell surface marker Siglec-9 and their use in the treatment of cell proliferation disorders and assays.BACKGROUND[0002]Sialic acid-binding immunoglobulin-like lectins (Siglec(s)) are I-type lectins that are expressed by a number of cells including cells of the haematopoietic system. The Siglecs comprise a number of families of molecules, each characterised by the presence of a N-terminal V-set Ig-like domain, which mediates sialic acid binding, followed by varying numbers of C2-set Ig-like domains4.[0003]CD33 and the CD33 related siglecs encompass eight of the 11 human siglecs. These molecules share a high degree of sequence similarity and show significant differences in composition amongst mammalian species. The genes encoding these receptors are clustered on chromosome 19q13.3-13.4 and appear to be predominantly expressed in the haematopoietic and immune systems and exhibit differential expression p...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/395G01N33/53A61P35/00A61K38/00A61K47/48C07K16/28G01N33/50G01N33/574
CPCA61K38/00A61K47/48407A61K47/48561C07K16/2803A61K39/3955G01N33/5011G01N33/57488A61K31/70A61K38/02C07K2317/77A61K47/6809A61K47/6849A61P35/00A61P35/02A61P43/00
Inventor CROCKER, PAUL RICHARDBIEDERMANN, BJOERN
Owner UNIV COURT OF THE UNIV OF DUNDEE
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