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Embolic compositions with non-cyanoacrylate rheology modifying agents

a technology of cyanoacrylate and rheology modification agent, which is applied in the field of polymer compositions, can solve the problems of shrinking or dying of tumors or abnormalities, and achieve the effect of shrinking or dying tumors or abnormalities

Inactive Publication Date: 2010-06-10
STRYKER EURO OPERATIONS HLDG LLC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a composition that can be used to treat vascular abnormalities such as aneurysms, fistulas, and tumors. The composition includes a matrix-forming component and a solid-aggregate material, which can be a radiopaque powder. The composition can be administered as a liquid or solid and quickly solidifies to form a rubbery polymeric matrix when exposed to an ionic environment. The solid composition can be used to occlude blood vessels or embolize vascular spaces. The technical effect of the invention is the ability to provide a safe and effective treatment for vascular abnormalities.

Problems solved by technology

A tumor or abnormality is occluded by cutting off the blood supply to the diseased area, resulting in diminished growth or death of the tumor or abnormality.

Method used

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Examples

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Embodiment Construction

[0012]Therefore, in one aspect, the invention relates to matrix-forming components comprising an alkyl cyanoacrylate monomer in combination with at least a stabilizer and a plasticizer. The matrix-forming components also can include a polymeric rheology modifying agent. The matrix-forming components can be used with one or more solid-aggregate materials. All the materials used are either incorporated into a single injectable embolic composition along with the matrix-forming components or can be included in one of a number of separately packaged mixtures that are combined prior to use to form the embolic composition. The stabilizing component is comprised of an acidic stabilizer, a free radical inhibitor, an antioxidant, or a mixture thereof. The plasticizer can be selected from a group of polymeric or non-polymeric compounds that impart flexibility, prevent brittleness, reduce adhesiveness to catheter delivery devices, and are compatible with alkyl cyanoacrylate monomers. The solid-...

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PUM

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Abstract

Compositions for embolization are disclosed herein. The compositions disclosed can have a matrix-forming component, a solid-aggregate material, and a rheology modifying agent, wherein the matrix-forming component includes at least alkyl cyanoacrylate monomers, a stabilizer, and a plasticizer, and the solid-aggregate material includes at least a radiopacifier. The composition and a method of administering the composition are useful for treating vasculature abnormalities, particularly when the composition solidifies upon contact with an ionic environment, such as blood.

Description

FIELD OF THE INVENTION[0001]The present invention relates generally to polymer compositions, and more particularly, liquid polymer compositions capable of forming a solid embolic block upon administration in an ionic environment, such as blood. The composition can be used for treating vascular abnormalities, including brain aneurysms. In particular, the compositions of the present invention comprise a matrix-forming component and a solid-aggregate material, which can combine to form an embolic composition upon administration.BACKGROUND OF THE INVENTION[0002]Vascular embolization often is the chosen method for controlling bleeding in the blood vessels or occluding blood supply to solid mass tumors or vascular aneurysms. Currently available therapeutic regimens for treating solid mass tumors can be difficult to administer, particularly depending on the properties of the embolic, or bulking, composition used. Aneurysms, arteriovenous malformations (“AVMs”) and other vascular abnormalit...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K47/30A61K47/36A61K47/38A61K47/02A61L31/00A61L24/06C08F2/44C08F20/32C08F291/00
CPCA61L24/06C08F20/32A61L2430/36C08L35/04
Inventor PORTER, STEPHEN C.
Owner STRYKER EURO OPERATIONS HLDG LLC
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