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Transcranial magnetic stimulation (TMS) methods and apparatus

a transcranial magnetic and stimulation technology, applied in the field of transcranial magnetic stimulation, can solve problems such as unintended and undesirable side effects, and achieve the effect of preventing epilepsy

Inactive Publication Date: 2010-08-19
BETH ISRAEL DEACONESS MEDICAL CENT INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011]Another aspect of the invention relates to a method of preventing epilepsy. The method comprises identifying an epilepsy precipitating occurrence or predisposition (genetic or acquired) and exposing a brain of the subject to rTMS.

Problems solved by technology

The effects that are assessed may be intended, desirable therapeutic effects or may be unintended and undesirable side effects.

Method used

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  • Transcranial magnetic stimulation (TMS) methods and apparatus
  • Transcranial magnetic stimulation (TMS) methods and apparatus
  • Transcranial magnetic stimulation (TMS) methods and apparatus

Examples

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example i

[0106]Anti-seizure effect of daily 1 Hz repetitive transcranial magnetic stimulation (rTMS) in a case of pediatric Rasmussen's encephalitis.

[0107]1 Hz rTMS was applied in daily sessions over the affected hemisphere to ameliorate intractable nearly-continuous right anterior focal seizures in a 14-year-old boy with progressive focal epilepsy, left hemiparesis and right hemisphere atrophy.

[0108]As explained above, rTMS is a method for noninvasive focal cortical stimulation that is based on the principles of electromagnetic induction. During rTMS small intracranial electrical currents are generated by a powerful fluctuating extracranial magnetic field. Low frequency (1 Hz) rTMS is emerging as a new therapeutic tool in epilepsy with a limited number of reports showing the capacity of rTMS to reduce seizure frequency and to interfere with ongoing seizures. We present a case of gradual seizure reduction with recurrent daily rTMS in a pediatric patient with Rasmussens encephalitis. The pati...

example ii

[0112]As shown in FIGS. 11A-11E, TMS methods were adapted for application to gently-restrained, seizing rats. EEG readings were recorded with three subdermal wire electrodes (SWEs), One SWE was placed on the torso to record EKG and two more wires were used as antennae to detect the TMS pulse and to identify timing of the pulse. Torso restraint permits clinical observation of seizures and full access of the head to the TMS coil. Slew-rate limited preamplifiers were included in series to the EEG acquisition system to minimize TMS-related amplifier saturation, as represented by FIGS. 12A and 12B, which show a reduced TMS artifact with slew-rate limited pre-amplifier.

[0113]Seizures were Induced with intraperitoneal kainate (KA) 11 mg / kg in young adult male Long-Evans rats, Real-time EEG was recorded and assessed for seizure discharges. A 0.5H rTMS was applied during seizures with a figure-8 coil positioned overhead. A set of rats was sacrificed and perfused 2.5 hours after KA na KA+0.5 ...

example iii

[0115]EEG and TMS techniques were combined to enables a closed-loop system where seizures were recognized and treated with an electrical current induced by a fluctuating extracranial magnetic field. As shown in FIG. 13, a spontaneous seizure in a rat was recognized and terminated with TMS.

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Abstract

Method and devices are provided for treating subjects with Transcranial Magnetic Stimulation (TMS). According to some approaches, the methods and devices are configured for the treatment of ongoing seizures. Other approaches relate to the use of TMS as an antiepileptogenic or for use in determining preferential placement of intracranial probes.

Description

[0001]This application claims the benefit of U.S. Provisional Application Ser. No. 60 / 872,207, filed Dec. 1, 2006, which is hereby incorporated by reference in its entirety.FIELD[0002]The present invention relates to transcranial magnetic stimulation (TMS).DISCUSSION OF RELATED ART[0003]Transcranial magnetic stimulation (TMS) provides a non-invasive procedure for generating fluctuating magnetic fields to induce stimulating intracranial electric current to desired areas of the human body, typically targeted areas of the brain. In general, TMS procedures involve identifying a discrete region of the brain and focusing fluctuating magnetic fields generated by one or more coils positioned proximate the head at a location that induces electric current in the identified region of the brain. The type and character of the fluctuating magnetic field deposition, and the location of the targeted region of the brain typically depends on the type of therapeutic and / or diagnostic application that ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N2/04A61B5/375
CPCA61B5/0006A61B5/04001A61B5/0476A61N2/02A61B19/203A61N2/006A61N2/008A61B5/0482A61B5/4094A61B90/14A61B5/24A61B5/375A61B5/369
Inventor PASCUAL-LEONE, ALVAROROTENBERG, ALEXANDERGLASS, IAINJENSEN, FRANCES E.
Owner BETH ISRAEL DEACONESS MEDICAL CENT INC
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