Method for manufacturing of drug-releasing stent coated with titanium-oxide thin film
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example 1
Preparation of Titanium Dioxide and Nitrogen-Doped Titanium Oxide (TiO2-xNx) Thin Films
[0052]A stent was fixed in a vacuum chamber connected to a radio frequency (RF) plasma generator and a vacuum pump using a titanium wire, as illustrated in FIG. 1. The temperature inside the plasma chamber was maintained at 400° C. In order to improve adhesion between the stent and a thin film, the surface of the stent was cleaned by a plasma pretreatment process by flowing argon and oxygen, prior to the coating of the thin film. After adding titanium isopropoxide in a bubbler, the titanium isopropoxide was mixed with oxygen, a reactant gas, and introduced into the reaction chamber using argon as a carrier gas, while maintaining the temperature of the bubbler at 50° C. Then, a plasma was generated for 4 hours to coat a titanium dioxide thin film on the surface of the stent. The carrier gas argon was supplied at a rate of 100 sccm, and the reactant gas oxygen was supplied at a rate of 20 sccm. Vari...
example 2
Modification of Titanium Oxide Thin Film with Hydroxyl Groups
[0053]In order to chemically attach a drug on the surface of the coated titanium dioxide, the titanium oxide should have functional groups that can chemically bind to the functional groups of the drug molecules. Accordingly, the surface of titanium dioxide was modified using a low-temperature plasma and distilled water (H2O) in order to introduce hydroxyl (—OH) groups thereon. The titanium dioxide coated stent was fixed in a tubular low-temperature plasma reactor made of Pyrex. After filling triple distilled water in a bubbler, steam was supplied into the plasma reactor at a rate of 10 sccm. The titanium dioxide thin film was modified for 10 minutes via a low-temperature plasma process while varying discharge power from 10 to 100 W. The result of surface modification was confirmed by measuring a contact angle.
example 3
Manufacture of α-Lipoic Acid Attached Stent
[0054]A two-neck round flask connected to a reflux condenser was purged with nitrogen, and the surface-modified unit stent, α-lipoic acid (0.5 g), distilled water (5 mL) and strong sulfuric acid (20 μL) were added thereto. The mixture was stirred for 1 hour under a nitrogen atmosphere while maintaining the temperature at 55° C. Upon completion of the reaction, the stent was recovered, washed 3 times with ethanol, washed 3 times with flowing triple distilled water, blown with air, and dried in a desiccator.
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