Adjustable chromophore compounds and materials incorporating such compounds

a technology of chromophore compounds and compounds, which is applied in the field of adjustable chromophore compounds and materials, can solve the problems of chromophore compounds that tend to degrade, and achieve the effects of less absorption, enhanced light absorption of a nucleus portion, and enhanced light absorption

Inactive Publication Date: 2011-10-06
NOVARTIS AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

As a further advantage of the present invention, the predetermined radiation can be directed at particular portions of the lens to enhance light absorption in particular pre-selected regions of the lens while other regions of the lens will exhibit less absorption. For an IOL, for example, it might be desirable to enhance the light absorption of a nucleus portion of the IOL while leaving the peripheral portion of the IOL to exhibit less light absorption. Such an IOL would then exhibit the greater light absorption when light is bright and the pupil of the eye is small and would exhibit less absorption when there is less light and the pupil of the eye is larger. In such an embodiment, the nucleus region will typically have a concentration of the chromophore compound B—C that is greater than 120% and more typically greater than 150% of the concentration at a peripheral region of the lens. Such nucleus regions and such peripheral regions will both be at least 10% of the overall volume of the IOL excluding any haptics.
, the predetermined radiation can be directed at particular portions of the lens to enhance light absorption in particular pre-selected regions of the lens while other regions of the lens will exhibit less absorption. For an IOL, for example, it might be desirable to enhance the light absorption of a nucleus portion of the IOL while leaving the peripheral portion of the IOL to exhibit less light absorption. Such an IOL would then exhibit the greater light absorption when light is bright and the pupil of the eye is small and would exhibit less absorption when there is less light and the pupil of the eye is larger. In such an embodiment, the nucleus region will typically have a concentration of the chromophore compound B—C that is greater than 120% and more typically greater than 150% of the concentration at a peripheral region of the lens. Such nucleus regions and such peripheral regions will both be at least 10% of the overall volume of the IOL excluding any haptics.

Problems solved by technology

It is also the case that some chromophore compounds tend to degrade over time due to absorption of light.

Method used

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  • Adjustable chromophore compounds and materials incorporating such compounds
  • Adjustable chromophore compounds and materials incorporating such compounds
  • Adjustable chromophore compounds and materials incorporating such compounds

Examples

Experimental program
Comparison scheme
Effect test

example 1

Example 1 above illustrates one exemplary embodiment of the invention. As can be seen, a chromophore compound B—X includes a benzotriazole base chromophore

(B) and an adjustable moiety (X), which is a dicyclopentadiene. The adjustable moiety (X) includes a mobilization inhibiting group (Z), which is preferably an alkane chain, and an electron donating moiety (D), which is preferably an alkoxy group. The base chromophore compound (B) includes an electron withdrawing group (W), which is preferably one of the halogen or halogenated groups discussed above. As can be seen, upon exposure to predetermined radiation, the chromophore compound B—X becomes the chromophore compound B—C and separable group (S) with the chromophore compound B—C having a conjugated double bond and the electron donating group (D) as well as the remaining group (C). The base chromophore (B) then includes the electron withdrawing group (W). Further, the separable group (S) includes the mobilization inhibiting group (Z...

example 2

Example 2 above illustrates another exemplary embodiment of the invention. As can be seen, a chromophore compound B—X includes a benzotriazole base chromophore (B) and an adjustable moiety (X), which is a dicyclopentadiene. The adjustable moiety (X) includes a mobilization inhibiting group (Z), which is preferably an alkane chain, and an electron withdrawing moiety (W), which is preferably a halogen group. The base chromophore compound (B) includes an electron donating group (D), which is preferably an alkoxy group. As can be seen, upon exposure to predetermined radiation, the chromophore compound B—X becomes the chromophore compound B—C and separable group (S) with the chromophore compound B—C having a conjugated double bond and the electron withdrawing group (W) as well as the remaining group (C). The base chromophore (B) then includes the electron donating group (D). Further, the separable group (S) includes the mobilization inhibiting group (Z).

example 3

Example 3 above illustrates another exemplary embodiment of the invention. As can be seen, a chromophore compound B—X includes a benzotriazole base chromophore (B) and an adjustable moiety (X), which is a dicyclopentadiene. In this example, a cyclic moiety of the base chromophore (B) and the dicyclopentadiene share a common bond. The adjustable moiety (X) includes a mobilization inhibiting group (Z), which is preferably an alkane chain. Further, the base chromophore (B) includes an electron withdrawing moiety (W), which is preferably a halogen group and an electron donating group (D), which preferably includes an alkoxy group. As can be seen, upon exposure to predetermined radiation, the chromophore compound B—X become the chromophore compound B—C and separable group (S) with the chromophore compound B—C having a conjugated double bond as the remaining group (C) and the electron withdrawing group (W). The base chromophore (B) also includes the electron donating group (D). Further, t...

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Abstract

The present invention is directed to adjustable chromophore compounds and materials (e.g., ophthalmic lens materials) incorporating those compounds. The adjustable chromophore compounds include a chemical moiety that structurally changes upon exposure to predetermined electromagnetic radiation (e.g., two photon radiation) as well as lens materials, particularly intraocular lens materials that incorporate those compounds.

Description

TECHNICAL FIELD OF THE INVENTIONThe present invention is related to adjustable chromophore compounds and materials (e.g., ophthalmic lens materials) incorporating those compounds. More particularly, the present invention is related to adjustable chromophore compounds that includes a chemical moiety that structurally changes upon exposure to predetermined electromagnetic radiation (e.g., two photon radiation) as well as lens materials (e.g., intraocular lens materials) that incorporate those compounds.BACKGROUND OF THE INVENTIONChromophore compounds are molecules that absorb light and such light absorption is desirable for a wide range of products. They are particularly important and useful in lenses of many different types. As examples, chromophores have been incorporated into lenses of sunglasses, lenses of spectacles, contact lenses and intraocular lenses (IOLs). As such, a significant amount of research has been performed investigating a wide variety of compounds with light absor...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F9/007C07D249/20G02B5/23
CPCA61L27/50A61L2430/16B29D11/00461C07D249/20C08K5/3475G02B1/043C08L33/08B01J19/123B01J19/127
Inventor WEINSCHENK, III, JOSEPH I.
Owner NOVARTIS AG
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