Adhesive structure with stiff protrusions on adhesive surface

a technology of adhesive surface and protrusion, applied in the field of polymer-based structures, can solve the problems of attractive or repulsive forces, short-range forces between them are repulsive, and the london dispersion force is typically very weak, so as to increase the physical attractive force and promote adhesion

Inactive Publication Date: 2012-06-07
AGENCY FOR SCI TECH & RES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016]The present invention relates to a laminate comprising: a (polymeric) surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.

Problems solved by technology

Such forces may be either attractive or repulsive in nature.
Generally, if molecules do not interact chemically, the short-range forces between them are repulsive.
London dispersion forces are typically very weak because the attractions are so quickly broken, and the charges involved are so small.
However, such structures are inherently delicate and can suffer from durability problems in practical applications.
Moreover, they do not provide a solution for adhesion to specific types of tissue.

Method used

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  • Adhesive structure with stiff protrusions on adhesive surface
  • Adhesive structure with stiff protrusions on adhesive surface
  • Adhesive structure with stiff protrusions on adhesive surface

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0141]The aim of this example was to fabricate polypropylene films with pillar like protrusions. A commercial track etched polycarbonate membrane was obtained from Millipore Corporation of Billerica, Mass., USA having pores of 0.6 microns diameter and a circular diameter of 2.5 cm, with a thickness of 20 microns. The membrane was used as a template to imprint a solvent-resistant polypropylene (PP) polymer film of 300 microns thickness, obtained from Ethicon, Inc. of Somerville, N.J., USA. The polypropylene film was pressed into the polycarbonate membrane template under controlled temperature and pressures (180° C., 600 kPa (6 bar)) for 20 minutes, melting the polypropylene and forming an overfilling of polypropylene to the top side of the membrane. The polypropylene polymer and the membrane are cooled to 175° C. before removal of pressure, after which the polymer structures are de-molded and released by dissolving the membrane in dichloromethane. The overfilling of polypropylene hol...

example 2

[0142]The aim of this example was to develop an accurate and reproducible test method to measure shear adhesion. Modifications were made to the mechanical testing instrument sold under the trade name INSTRON by Instron Industrial Products, Grove City, Pa. The mechanical testing set up was modified to improve the precision and reproducibility of the shear adhesion measurements of the films having pillar-like structures. The modifications were made to decrease the source of noise from the hardware components and control the preload or initial contact force between the adhesive surfaces. The standard clamp operated with compressed air to grip the glass slide was replaced by a fixed rigid clamp and the length of the glass slide was shortened to reduce noise due to cantilever bending effect. Similarly, the length of the lower glass slide was shortened to reduce noise. A solid block of aluminum was used as a backing for the glass slide. A control of preload was added consisting of: a spri...

example 3

[0143]The polypropylene pillared substrate prepared as described in Example 1 as well as its corresponding flat surface film (unpillared) were tested for shear adhesion against substrates (sandpaper) with varying surface roughness values under wet conditions i.e. the substrates and the structures were immersed in DI water and the mechanical testing was then conducted by the method described in Example 2. This was done to mimic the wet conditions that exist in-vivo. The surface roughness value represents the average feature dimensions expected for different surfaces. These tests were performed using a mechanical tester sold under the trade name INSTRON (Instron Industrial Products, Grove City, Pa.) and the results are summarized in FIG. 2. The results clearly show that the flat, unpatterned PP films show uniformly low adhesion over all substrate roughnesses. The adhesion of the PP nanopillars (1 micron diameter and 20 microns length) was higher than its flat counterpart, as well as b...

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Abstract

A laminate and process of making the laminate is disclosed comprising: a surgical mesh having first and second surfaces; and an adhesive structure having adhesive and non-adhesive surfaces, wherein the non-adhesive surface of the adhesive structure is laminated to at least one of said first and second surfaces of said surgical mesh, and the adhesive surface of said adhesive structure has protrusions extending therefrom comprising a resin having a Young's modulus of greater than 17 MPa, which protrusions are of sufficiently low diameter to promote adhesion by increasing physical attractive forces between the adhesive structure and a target surface, as measured by shear adhesion.

Description

[0001]This application is a continuation-in-part of, and claims the benefit of priority under 35 U.S.C. §120 to U.S. application Ser. No. 12 / 871,745, filed Aug. 30, 2010, which is incorporated by reference herein in its entirety.FIELD OF THE INVENTION[0002]The present invention relates to polymer-based structures having shapes and mechanical properties that optimize adhesion to a specific target, e.g., a tissue or organ target.BACKGROUND OF THE INVENTION[0003]There is an ongoing need for adhesive structures having improved adhesion obtained through physical attractive forces. Such structures can be suited to use in various applications, such as medical applications, e.g., as an adjunct or replacement to sutures and staples used to close surgical incisions. For the adhered to substrate, e.g., living tissue, providing an adhesive structure that provides adhesive forces by non-chemical interactions between adhesive structure and substrate would be highly desirable.[0004]Intermolecular ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B17/03B29C70/00C09J7/21C09J7/30
CPCA61B2017/00871A61F2/0063A61B2017/00942A61B2017/00951A61L31/048A61L31/06B29C33/52C09J7/041C09J2201/32C09J2400/263A61L31/10A61B2017/00938C08L23/12C08L67/04C09J7/30C09J7/21C09J2301/206
Inventor NATARAJAN, SRIRAMHAMMER, JOSEPH J.COOPER, KEVINVYAKARNAM, MURTY N.LOW, HONG YEERODRIGUEZ, ISABELLIM, CHEE TIONGHO, AUDREY YOKE YEE
Owner AGENCY FOR SCI TECH & RES
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