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Package

a technology for packaging and food, applied in the field of packaging, can solve the problems of insufficient moisture barrier properties and relatively low protective effect of the object to be packaged, and achieve the effects of high moisture barrier properties, enhanced moisture adsorption properties, and convenient processing

Inactive Publication Date: 2013-06-20
ASTELLAS PHARMA INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a packaging solution for solid preparations which has excellent moisture-proofing properties achieved through an adsorption layer on top of a flexible substrate layer and aluminum foil. This allows for easy processing without heating and improves both moldability and product yields compared to traditional methods. Additionally, the design prevents the formation of pinholes near the opening of the package. Incorporating a specific type of clay called zeolite into the adsorption layer results in better protection against oxidization and coloration, ensuring optimal preservation of the solid preparation.

Problems solved by technology

The technical problem addressed in this patent text is the inadequacy of moisture barrier properties in PTP packages containing drugs or highly hygroscopic objects, which can result in insufficient protective effects. The patent text suggests the use of a container with high moisture barrier properties, such as aluminum foil, and a cover material with a moisture adsorptive layer or a desiccant function to improve the moisture barrier properties of the package.

Method used

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Examples

Experimental program
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Effect test

example 2

Configuration of Package Film F1

[0089]Adsorption layer 1: A two-component three-layer film in which a zeolite (manufactured by Union Showa K.K., trade name: MOLECULAR SIEVE 4A, effective pore diameter: 4 Å)-containing LDPE (manufactured by Tosoh Corp., trade name: PETROTHENE 202, thickness: 50 μm) layer is laminated on both surfaces with a skin layer of LLDPE (manufactured by Prime Polymer Co., Ltd., trade name: EVOLUE (registered trademark) SP2520)

[0090]Substrate layer 2: PVC (polyvinyl chloride) (thickness: 60 μm)

[0091]Aluminum foil 3: An aluminum alloy foil (manufactured by Sumikei Aluminum Foil Co., Ltd., trade name: BESPAII, thickness: 40 μm)

[0092]Barrier layer 4: PA (polyamide-based resin) (manufactured by Toyobo Co., Ltd., trade name: HARDEN N2102, thickness: 15 μm)

example 3

Configuration of Package Film F1

[0100]Adsorption layer 1: A two-component three-layer film in which a zeolite (manufactured by Union Showa K.K., trade name: MOLECULAR SIEVE 4A, effective pore diameter: 4 Å)-containing LDPE (manufactured by Tosoh Corp., trade name: PETROTHENE 202, thickness: 130 μm) layer is laminated on both surfaces with a skin layer of LLDPE (manufactured by Prime Polymer Co., Ltd., trade name: EVOLUE (registered trademark) SP2520)

[0101]Substrate layer 2: PA (polyamide-based resin) (Manufactured by Kohjin Holdings Co., Ltd., trade name: BONYL W, thickness: 15 μm)

[0102]Aluminum foil 3: An aluminum alloy foil (manufactured by Toyo Aluminum K.K., trade name: SUPERFOIL, thickness: 40 μm)

[0103]Barrier layer 4: PA (polyamide-based resin) (manufactured by Kohjin Holdings Co., Ltd., trade name: BONYL W, thickness: 15 μm)

example 1

[0124]The solid preparation 8 obtained in the Preparation Example above was sealed in by bonding a container sheet 6 formed from a package film F1 having the following configuration with a cover material sheet 7 formed by aluminum, and thereby a package P was obtained. Meanwhile, since the configuration of the package film F1 that constitutes the container sheet 6 of Example 1 is the same as the configuration used in Example 1 as described above, further explanation will not be repeated.

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Abstract

Provided is a package that exhibits satisfactory moldability as well as moisture adsorption and gas adsorption properties.
A package P includes a container sheet 6 in which a concave receptacle unit 5 that accommodates a solid preparation 8 containing solifenacin succinate or 1-{[α-isobutanoyloxyethoxy]carbonyl}aminomethyl}-1-cyclohexaneacetic acid is formed, and an airtight cover material sheet 7 for sealing the solid preparation 8. The container sheet 6 is formed by a package film F1 in which an adsorption layer 1, at least one or more substrate layers 2 formed by resins, an aluminum foil 3, and a barrier layer 4. The adsorption layer 1 is laminated with the substrate layer 2 while also being disposed on the side where the solid preparation 8 is accommodated, and contains at least zeolite.

Description

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Claims

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Application Information

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Owner ASTELLAS PHARMA INC
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