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Method and system for combining anatomical connectivity patterns and navigated brain stimulation

a brain stimulation and connectivity technology, applied in the field of brain stimulation system mapping of brain functions, can solve the problems of insufficient anatomical image of the brain of a subject undergoing stimulation, altered or damaged brain anatomy, etc., and achieve the effect of complete and realistic view

Inactive Publication Date: 2013-07-11
NEXSTIM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a system and method for navigated brain stimulation with improved visualization of the affected brain network, increased accuracy of diagnostic information, and safer resections. The system includes a stereotactic positioning system and display of functional data highlighting functionally active areas relevant to the procedure. The MRI technique of diffusion tensor imaging has made it possible to map local and remote anatomical connections formed by cerebral white matter, which enriches the information available to the operator and leads to better understanding of diagnostic information and more informed targeting of therapeutic stimulation. Overall, the invention improves the accuracy, precision, and safety of brain stimulation procedures.

Problems solved by technology

However, many times the brain anatomy of a subject undergoing stimulation has been altered or damaged by trauma or tumor.
As such, an anatomical image of the subject's brain may not be sufficient to determine the functionality of certain portions of the brain.

Method used

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  • Method and system for combining anatomical connectivity patterns and navigated brain stimulation
  • Method and system for combining anatomical connectivity patterns and navigated brain stimulation
  • Method and system for combining anatomical connectivity patterns and navigated brain stimulation

Examples

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Embodiment Construction

[0022]A computer assisted stereotactic positioning system associated with a stimulating device can be used to determine portions of the central nervous system targeted by the stimulation either to guide the placement of a stimulation probe or to explain the diagnostic information or effects caused by the stimulating device.

[0023]Different technical restrictions apply to invasive and noninvasive stimulation devices. Invasive stimulation devices can be placed in direct contact with the tissue being stimulated. Invasive devices are assumed to directly activate the tissue being in direct contact with the stimulating probe.

[0024]Non-invasive stimulation devices must typically rely on crude approximations of stimulation effects or rely on real-time or offline modeling of stimulation effects. Invasive techniques may use real-time or offline modeling and approximations of stimulation effects in particular for planning of installation of implantable devices and adjustments to stimulation par...

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Abstract

When operating a brain stimulation device, it is critical to understand and control the network effects associated with the area being targeted for stimulation. The combined system and methods provided herein provides the operator with a real-time view of the brain network potentially affected by the stimulation. The system and method are capable of increasing the accuracy of diagnostic information. Additionally, disclosed herein are a system and method for combining navigated brain stimulation data and anatomical data with brain connectivity data for an individual.

Description

FIELD OF INVENTION[0001]The present invention relates to the mapping of brain functions and treating disorders using a brain stimulation system and in particular the determination of anatomical and functional relationships in the brain.BACKGROUND OF THE INVENTION[0002]The aim of operating a brain stimulation device on a patient's brain may be to either cause an evoked response for diagnostic purposes, or to cause a transient or permanent change in the brain function for therapeutic purposes. The effectiveness of a brain stimulation method depends on how well the stimulating device and the stimulating energy reach the intended anatomical region being targeted.[0003]One solution is to use a stereotactic arrangement to accomplish a positioning of stimulation equipment in relation to the targeted anatomical portions of the body. Typically stereotactic navigation devices use anatomical images (structural images from MRI or CT) to correlate stereotactic instruments to individual anatomy. ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61N2/00
CPCA61B5/0042A61B5/0488A61B5/055A61B5/061A61N2/02A61B5/7425A61B19/5244A61B2576/026A61N2/006A61B5/4064A61B34/20G16H30/40A61B5/389A61B6/037A61B6/501
Inventor NEUVONEN, TUOMASHANNULA, HENRI
Owner NEXSTIM
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