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Medical product with a particle-free coating releasing an active substance

a technology of active substances and medical products, applied in the field of medical products, can solve the problems of insolubility in water and particle release during dilatation

Inactive Publication Date: 2013-09-19
HEMOTEQ AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent is about a way to make medical devices that have a coating with an active substance and a carrier. This coating can be applied to the device by spraying it onto the surface and it helps to prevent the active substance from forming particles during use. This invention solves a problem that can occur when using certain active substances on medical devices.

Problems solved by technology

Exactly these highly effective active substances show the above described disadvantages concerning the particle release during dilatation and insolubility in water.

Method used

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  • Medical product with a particle-free coating releasing an active substance

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of a Coating Solution of Paclitaxel (Ptx) and Dexpanthenol

[0137]Herefore 120 mg paclitaxel (Sigma-Aldrich Chemie GmbH, Germany) is dissolved in acetone. Likewise 30 mg dexpanthenol (Cal Roth GmbH, Germany) is dissolved in 500 μl ethanol. Afterwards both solutions are combined.

example 2a

Preparation of a Coating Solution of Paclitaxel (Ptx) and PEG (1:2:2 w:w:w)

[0138]Herefore 100 mg paclitaxel and 200 mg PEG A and 200 mg PEG B are dissolved in 1000 μl acetone.

[0139]PEG A is PEG 400 (Sigma-Aldrich Chemie GmbH, Germany) and has a molecular mass between 380 and 420 and an average molecular mass Mn of 400.

[0140]PEG B is a polyethylene glycol (Sigma-Aldrich Chemie GmbH, Germany) with a molecular mass between 950 and 1050.

example 2b

Preparation of a Coating Solution of Sirolimus and PEG (1:2:2 w:w:w)

[0141]Herefore 100 mg sirolimus (Merck4Biosciences, Germany) is dissolved in ethyl acetate and 200 mg PEG A and 200 mg PEG B are dissolved in 1000 μl absolute ethanol. Both solutions are combined.

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Abstract

Embodiments described herein concern medical products, which come into contact with the organism, such as short-term implants and long-term implants, coated with at least one layer, containing a molecular-disperse distributed or dissolved active substance in at least one carrier and optionally one or more adjuvants, wherein the at least one layer forms a stably spreadable solution, methods for making this coating of stably spreadable solution and use of the medical products coated with the stably spreadable solution.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention concerns medical products, which come into contact with the organism, such as short-term implants and long-term implants, coated with at least one layer, containing a molecular-disperse distributed or dissolved active substance in at least one carrier and optionally one or more adjuvants, wherein the at least one layer forms a stably spreadable solution, methods for making this coating of stably spreadable solutions and use of the medical products coated with the stably spreadable solution.[0003]2. Description of the Relevant Art[0004]In the past, improvements concerning balloon catheters related primarily on their ability to place a stent precisely and safely. The PTCA as an independent method was—and is still—used primarily to remove existing stenosis by temporary dilatation and thereby widening of the vessel, but was largely replaced in the coronary field by stent implantation as permanent vesse...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L29/16A61K31/436A61K31/337A61F2/958
CPCA61L29/085A61L29/16A61K31/436A61K31/337A61L29/08A61P41/00A61M25/10
Inventor HOFFMANN, ERIKAHOFFMANN, MICHAELHORRES, ROLAND
Owner HEMOTEQ AG
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