Blood-tissue surface based radiosurgical renal treatment planning

Abstract

Devices, systems, and methods for planning radiosurgical treatments for neuromodulating a portion of the renovascular system may be used to plan radiosurgical neuromodulation treatments for conditions or disease associated with elevated central sympathetic drive. The renal nerves may be located and targeted at the level of the ganglion and/or at postganglionic positions, as well as preganglionic positions. Target regions include the renal plexus, celiac ganglion, the superior mesenteric ganglion, the aorticorenal ganglion and the aortic plexus. Planning of radiosurgical treatments will optionally employ a graphical representation of a blood/tissue interface adjacent these targets.

Description

CROSS-REFERENCES TO RELATED APPLICATIONS[0001]This application claims priority to and is a continuation of PCT / US2013 / 077176, filed Dec. 20, 2013, entitled “BLOOD-TISSUE SURFACE BASED RADIOSURGICAL RENAL TREATMENT PLANNING”, which claims the benefit under 35 U.S.C. §119(e) of U.S. provisional application No. 61 / 746,738, filed Dec. 28, 2012, entitled “BLOOD-TISSUE SURFACE BASED RADIOSURGICAL RENAL TREATMENT PLANNING”, the contents of which are incorporated herein by reference in their entirety.BACKGROUND OF THE DISCLOSURE[0002]Radiosurgery is a medical procedure that allows non-invasive treatment of tumors and other targets in the head, spine, abdomen, heart, and lungs. During radiosurgery, a series of beams of ionizing radiation are often directed from outside a patient so as to converge at a target region. The radiation beams often comprises MeV X-ray beams fired from different positions and orientations. The beam trajectories help limit radiation exposure to the intermediate and o...

AI Technical Summary

Benefits of technology

[0008]The present invention generally provides improved devices, systems, and methods for planning radiosurgical treatments for alleviating renovascular hypertension. Certain embodiments of the invention may provide a three-dimensional model of a renovascular target region which may help a physician better visualize the target region. A three-dimensional model of a blood/vessel boundary surface of a blood vessel adjacent to a renovascular nerve may be provided. Certain embodiments may receive input with reference to a radiation target which is offset from a three-dimensional model of blood/vessel boundary surface and/or may generate a three-dimensional model of an estimated target location by radially offsetting a distance from a blood/vessel boundary surface of a blood vessel adjacent to the renovascular target. Such embodiments may optionally receive input regarding a radiation target on an estimated target location surface. The input of the desired radiation target may be fac...

Problems solved by technology

The expected consequence of high doses of radiation on a large arte...

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