Protective Effects of Oil Palm Composition on Alzheimer's Disease
Inactive Publication Date: 2016-09-01
MALASIAN PALM OIL BOARD
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Benefits of technology
The invention is about a compound made from oil palm phenolics (OPP) that can prevent or treat Alzheimer's disease and related cognitive disorders. This compound stops the buildup of harmful proteins in the brain associated with Alzheimer's disease. It also prevents the formation of larger, toxic aggregates of proteins and inhibits the buildup of specific protein structures in the brain. Overall, this compound has the potential to slow the progression of Alzheimer's disease.
Problems solved by technology
Alzheimer's disease (AD) is an incurable neurodegenerative disease that progressively worsened and eventually led to death.
During the early stage, there is difficulty with acquiring new memories so that it is difficult to recall recent events.
The amyloid beta peptide can form dimers which are quite toxic to neurons.
These soluble Aβ dimers are also known to interfere with memory of learning behavior in rodents' brains.
It has also demonstrated that soluble Aβ dimers interfere with glutamatergic synaptic transmission, where mGluRs are necessary for LTD induction.
Direct injection of oAβ / ADDLs into the hippocampi of live rats has caused cognitive and memory losses characteristic of Alzheimer's disease.
The glycosaminoglycan homotaurine (3-aminopropanesulfonic acid) also has anti-aggregation properties, however this compound has failed Phase III clinical trials in US and therefore it is no longer in use clinically.
Method used
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[0039]The embodiments herein and the various features and advantageous details thereof are explained more fully with reference to the non-limiting embodiments that are illustrated in the accompanying drawings and detailed in the following description. Descriptions of well-known components and processing techniques are omitted so as to not unnecessarily obscure the embodiments herein. The examples used herein are intended merely to facilitate an understanding of ways in which the embodiments herein may be practiced and to further enable those of skill in the art to practice the embodiments herein. Accordingly, the examples should not be construed as limiting the scope of the embodiments herein.
[0040]Present invention provides oil palm phenolics (OPP) which constitutes a water soluble extract from the palm fruit (Elaies guineensis) and are effective in treating Alzheimer's disease (AD) through inhibiting of beta amyloid peptides aggregation. The efficiency of this compound is validate...
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Present invention discloses an oil palm composition for use in prevention or treatment of Alzheimer's disease. The composition is useful in impeding formation of neurotoxic peptide. Present invention can be used in preparation of a medicament in a therapeutic effective amount for prevention or treatment of Alzheimer's disease and diseases related thereto.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a National Stage Application of International Application No. PCT / MY2014 / 000252, filed 10 Oct. 2014, which claims benefit of Serial No. PI 2013003739, filed 11 Oct. 2013 in Malaysia and which applications are incorporated herein by reference. To the extent appropriate, a claim of priority is made to each of the above disclosed applications.FIELD OF THE INVENTION[0002]The present invention relates to a composition with protective effects treating Alzheimer's disease. More particularly, relates to the use of palm oil-based phenolics in impeding β-amyloid peptide aggregation.BACKGROUND OF THE INVENTION[0003]Alzheimer's disease (AD) is an incurable neurodegenerative disease that progressively worsened and eventually led to death. AD is often diagnosed in persons over the age of 65 years and has affected 36 million persons globally in 2010. At the current rate of increase in prevalence, it is predicted that AD will affect 1...
Claims
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Login to View More IPC IPC(8): A61K36/889
CPCA61K2236/15A61K36/889A23D9/007A23L33/105A23L33/115A61P25/28
InventorWEINBERG, ROBERT P.RHA, CHOKYUNSINSKEY, ANTHONY J.TAN, YEW AISAMBANTHAMURTHI, RAVIGADEVI
OwnerMALASIAN PALM OIL BOARD