A composition for preventing, treating, and improving of voiding dysfunction comprising extract of Piper longum L.

a technology of extract and composition, which is applied in the direction of drug compositions, plant/algae/fungi/lichens ingredients, dispersed delivery, etc., can solve the problems affecting the health-related quality of individual life, and causing voiding dysfunction at the rate of 1-2 in 10 people, so as to prevent, treat and improve the voiding dysfunction, and reduce the micturition pressure

Inactive Publication Date: 2017-04-06
DONG WHA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0032]The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.

Problems solved by technology

Various voiding dysfunction symptoms such as overactive bladder negatively affect health-related quality of individual life in various aspects, since the quality of individual life cannot help being lowered due to restricted intake of beverages, experience of inconvenience to frequently go to toilet, impact on personal relationship and social life, occurrence of health problems or insufficient sleep at night, and the like (Jeung Im KIM, Young Ho KIM, & Hyun Chul AHN, 2002; Yoo Sik LEE, 2001a).
Conditions of overactive bladder are related to involuntary contraction to result in state of bladder hyperactivity.
Although antimuscarinic drugs are now widely used as an initial standard treatment of the overactive bladder, there is still no report for internationally practiced and controlled clinical trials to certainly demonstrate effectiveness, and it is reported that since these drugs have anticholinergic property affected across nervous system, adverse effects such as thirst, constipation, blurred vision and acute urinary retention are occurred at the rate of 1-2 in 10 people.
In this case, it is known that if one does not immediately urinate, pain may be induced, and severely, the bladder may arbitrarily contact to proceed into urgency incontinence leaking urine.
To be defined as nocturnal urine, it should be necessary accompanied by sleep before and after voiding, and the patient with nocturia frequently wakes up and does not fall asleep easily, so that he is sleepy and tired in the daytime due to disturbed sleep to result in inconvenience in his daily life.
Furthermore, an elderly person has a problem to increase risk of fall or fracture.
However, it is not still known about an effect of improving voiding dysfunction with Piper Longum L.

Method used

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  • A composition for preventing, treating, and improving of voiding dysfunction comprising extract of Piper longum L.
  • A composition for preventing, treating, and improving of voiding dysfunction comprising extract of Piper longum L.
  • A composition for preventing, treating, and improving of voiding dysfunction comprising extract of Piper longum L.

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Experimental program
Comparison scheme
Effect test

formulation example 1

nes

1.1. Preparation of Powders

Extract of Piper Longum L. 100 mg

Lactose 100 mg

Talc 10 mg

[0139]The above components are mixed and filled in airtight powder bags to prepare powders.

1.2. Preparation of Tablets

Extract of Piper Longum L. 100 mg

[0140]Corn starch 100 mg

Lactose 100 mg

[0141]Magnesium stearate 2 mg

[0142]The above components are mixed, and then compressed according to general processes for preparing tablets to prepare tablets.

1.3. Preparation of Capsules

Extract of Piper Longum L. 100 mg

[0143]Corn starch 100 mg

Lactose 100 mg

[0144]Magnesium stearate 2 mg

[0145]According to general processes for preparing capsules, the above components are mixed and filled in gelatin capsules to prepare capsules.

1.4. Preparation of Injections

Extract of Piper Longum L. 100 mg

[0146]Sterile distilled water for injection q.s.

pH regulator g.s.

[0147]According to general processes for preparing injections, it is prepared from the above components at the above amounts per ample (2 ml).

1.5. Preparation of L...

formulation example 2

Functional Foods

Extract of Piper Longum L. 100 mg

[0150]Vitamin mixture q.s.

Vitamin A acetate 70 μg

Vitamin E 1.0 mg

Vitamin B1 0.13 mg

Vitamin B2 0.15 mg

Vitamin B6 0.5 mg

Vitamin B12 0.2 μg

Vitamin C 10 mg

Biotin 10 μg

[0151]Nicotinic acid amide 1.7 mg

Folic acid 50 μg

Calcium panthothenate 0.5 mg

Mineral mixture q.s.

Ferrous sulfate 1.75 mg

Zinc oxide 0.82 mg

Potassium dihydrogenphosphate 15 mg

Dicalcium phosphate 55 mg

Potassium citrate 90 mg

Calcium carbonate 100 mg

Magnesium chloride 24.8 mg

[0152]Although the above vitamin and mineral mixtures have been mixed from and composed of components relatively suitable to heal functional foods as the preferred example in the above composition ratio, it may be permitted to optionally vary the combination ratio, and according to general processes for preparing general health functional foods, the above components may be mixed, and then according to general methods, be used in preparing health function food compositions (for example, nutrient candy, etc.).

formulation example 3

Functional Beverages

Extract of Piper Longum L. 100 mg

[0153]Citric acid 1000 mg

Oligosaccharide 100 g

[0154]Plum extract 2 g

Taurine 1 g

[0155]Adding purified water to a total of 900 Ml

[0156]According to general processes for preparing health functional beverages, the above components are mixed, heated with stirring at 85° C. for about 1 hour, and then the resulting solution is filtered and obtained in a sterilized 2 l container, which is sealed and sterilized, with being kept under refrigeration, and then used in preparing health functional beverage compositions according to the present invention.

[0157]Although components relatively suitable to favorite beverages have been mixed and composed as the preferred example in the above composition ratio, it may be permitted to optionally vary the combination ratio, depending on regional or racial preference such as demanding classes, demanding nations and use.

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Abstract

The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving of voiding dysfunction, comprising extract of Piper Longum L. as an active ingredient. The extract of Piper Longum L. according to the present invention is not only harmless, but also has outstanding effects of preventing, treating and improving voiding dysfunction by being involved in various mechanisms related to voiding dysfunction simultaneously so that it may increase a micturition interval, decrease a micturition pressure, increase a bladder capacity, inhibit detrusor contraction and induce relaxation of detrusor.

Description

TECHNICAL FIELD[0001]The present invention relates to a pharmaceutical composition for preventing or treating voiding dysfunction and a health functional food for preventing or improving voiding dysfunction, comprising extract of Piper longum L. as an active ingredient.BACKGROUND ART[0002]Voiding dysfunction is referred to all the urination actions departing from normal voiding patterns. Voiding dysfunction may happen to anyone of men and women, which include neurogenic bladder developed by neurological abnormality, lower urinary tract symptoms and prostatic hyperplasia by non-neurogenic cause, female urinary diseases represented as urinary incontinence (Korean Continence Society, 2003). It was reported that adults have high prevalence in voiding dysfunction, and that while voiding dysfunction increases with their age, men particularly show linear increase. In lower urinary tract symptoms due to voiding dysfunction, all of men and women are believed to have the highest prevalence of...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K36/67A23L2/52A61K9/48A23L33/105A61K9/00A61K9/20
CPCA61K36/67A23V2002/00A61K9/0095A61K9/0019A61K9/20A61K9/48A23L33/105A23L2/52A61K2236/17A61K2236/331A61K2236/53A61K2236/55A61K2236/333A61K2236/35A61K9/0056A61P13/00A61P13/02A61P13/10A61P43/00A23V2200/30
Inventor PARK, DA-AECHANG, YOON-YOUNGKIM, KWANG-HYUNLEE, SANG-HOJEON, CHAN-SEOKLEE, HYUN-YONG
Owner DONG WHA PHARM CO LTD
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