The invention discloses papaya skin-protection cream containing multiple pure natural plant extracts and a preparation method thereof. The skin-protection cream is prepared from the following raw materials in proportion: a phase A comprising 50% of liquid paraffin, 9.15% of microcrystalline wax, 25% of paraffin, 6% of cera alba and 5% of hydrogenated lanolin, and a phase B comprising 0.2% of caprylic / capric triglyceride, 0.1% of lecithin, 0.4% of mosla chinensis maxim extract, 0.4% of ampelopsis grossedentata extract, 0.5% of tribulus terrestris extract, 0.4% of nutmeg extract, 1.5% of papaya extract, 0.5% of tocopheryl acetate, 0.5% of essence, 0.15% of bisabolol, 0.1% of olive extract and 0.1% of chitin. The papaya extract is adopted, especially a chitin ingredient is added, and multiple plant ingredients are combined, so that the papaya skin-protection cream has the effects of soothing, repairing and moistening skin, uncomfortable symptoms, caused by dryness, frangibility and an external factor, can be alleviated, and the skin is soft, comfortable and elastic.