Isolated Organ Evaluation and Treatment

Abstract

The present invention relates to methods of evaluating and / or treating organs during isolated organ perfusion, and kits for carrying out this evaluation.

Description

FIELD OF INVENTION[0001]The present invention relates to methods of evaluating and treating organs during isolated organ perfusion, and kits for carrying out this analysis.BACKGROUND TO THE INVENTION[0002]Organs that can be transplanted from one person or animal to another include the heart, kidneys, liver, lungs, pancreas and bowels. Kidney transplants are most commonly performed. Transplants of the heart, liver and lungs are also regularly carried out. However, there are many more people in need of organ transplants than organs available and, tragically, many people die while waiting for a suitable organ.[0003]It is very important that organs are kept in the best possible condition between harvesting and transplantation. In order to maintain the organ in the best possible condition, the organ can be isolated from the blood circulation of the donor, and perfused with a Perfusate. For example, ex vivo lung perfusion (EVLP) is today considered a safe procedure with the capacity to in...

AI Technical Summary

Benefits of technology

The patent text describes a method for evaluating and treating organs used for transplantation. This method involves measuring biomarkers in the perfusate of the organ and comparing them to reference values to determine if the organ is suitable for transplantation. This objective parameter helps clinicians make informed decisions when selecting or deselecting an organ for transplantation. The combination of biomarkers measured provides particularly good predictions of which organs will be successful for transplantation and improves patient outcomes. The invention also includes methods for treating organs during isolated organ perfusion, which can help improve their quality for transplantation. The ultimate goal of this invention is to enhance the success rate of transplantation and increase the number of lives saved through organ transplantation.

Problems solved by technology

However, there are many more people in need of organ transplants than organs available and, tragically, many people die while waiting for a suitable organ.

However, the procedure is only carried out at a few lung transplantation centers around the world.

However, one of the current difficulties is that methods for evaluating an organ to determine whether or not it is suitable for transplantation are not very advanced.

While these parameters provide some information to the user, they do not give definitive information about whether or not an organ should be selected for transplant and so the decision to transplant or not is still largely based on subjective evaluation.

However despite several publications these markers have not been shown to be useful in a clinical setting.

One reason being that they are generally not analyzed with point-of-care (PoC) methods and therefore the information, even if clinically valuable, is not available to the Clinicians when the decision to transplant or not has to be made.

Furthermore, Ischemia Reperfusion Injury (IRI) is a well-known complication to organ transplantation.

Although an acute phase reaction, the effects of this early injury are believed to be a significant contributor to later morbidity and mortality in the organ recipients.