Isolated Organ Evaluation and Treatment

a technology of organs and isolation, applied in the field of organ evaluation and treatment, can solve the problems of not being useful in clinical settings, the method of evaluating an organ to determine whether or not it is suitable for transplantation is not very advanced, and many people die, so as to improve patient outcomes and good predications

Inactive Publication Date: 2018-06-28
XVIVO PERFUSION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0016]In order to use the method for evaluating the organ in practice, the measured concentrations in the Perfusate of the one or more biomarkers are compared against reference values, and the organ is then selected or deselected on the basis of how the measured concentrations compare with the reference values. This gives the clinician an objective parameter to use to determine whether or not the organ is suitable for transplantation. While the concentration of just one of the selected biomarkers can give valuable information in evaluating an organ, this method is particularly valuable where the concentration of at least two of the biomarkers is measured. The combinatorial analysis can lead to particularly good predications of

Problems solved by technology

However, there are many more people in need of organ transplants than organs available and, tragically, many people die while waiting for a suitable organ.
However, the procedure is only carried out at a few lung transplantation centers around the world.
However, one of the current difficulties is that methods for evaluating an organ to determine whether or not it is suitable for transplantation are not very advanced.
While these parameters provide some information to the user, they do not give definitive information about whether or not an organ should be selected for transplant and so the decision to transplant or not is still largely

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

TF in Perfusate

[0077]45 sets of human lungs were perfused ex vivo using STEEN Solution as the Perfusate. The perfusion was performed up to seven hours, although in most cases the perfusion was stopped after three or four hours, either to transplant the lung or to discard a lung that was not considered suitable for transplantation. The Perfusate was collected and frozen for subsequent immunologic analysis of TF. Samples were normally collected at the beginning and then every hour. However, not all cases had samples collected at every time point. This was attributed to the clinical situation where the sample collection was to take place. Taking care of the organ was the primary task collection of samples necessarily came second.

[0078]When the data is aggregated it can be shown that discarded lungs have a higher increase of TF then transplanted lungs. For each individual lung this is not always the case, and some transplanted lungs have values outside a suggested cut-off. Had the prese...

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PUM

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Abstract

The present invention relates to methods of evaluating and/or treating organs during isolated organ perfusion, and kits for carrying out this evaluation.

Description

FIELD OF INVENTION[0001]The present invention relates to methods of evaluating and treating organs during isolated organ perfusion, and kits for carrying out this analysis.BACKGROUND TO THE INVENTION[0002]Organs that can be transplanted from one person or animal to another include the heart, kidneys, liver, lungs, pancreas and bowels. Kidney transplants are most commonly performed. Transplants of the heart, liver and lungs are also regularly carried out. However, there are many more people in need of organ transplants than organs available and, tragically, many people die while waiting for a suitable organ.[0003]It is very important that organs are kept in the best possible condition between harvesting and transplantation. In order to maintain the organ in the best possible condition, the organ can be isolated from the blood circulation of the donor, and perfused with a Perfusate. For example, ex vivo lung perfusion (EVLP) is today considered a safe procedure with the capacity to in...

Claims

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Application Information

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IPC IPC(8): G01N33/50G01N33/68A01N1/02
CPCG01N33/5082G01N33/6893A01N1/021A01N1/0226
Inventor NILSSON, MAGNUSSIGVARDSSON, ANNE-LI
Owner XVIVO PERFUSION
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