Device for administering an active substance and method for operating said device

Abstract

A device for administering an active substance comprises a multi-chamber carpule having a bypass in one wall and at least one first chamber with a solid active substance and a second chamber with a solvent for the active substance, the second chamber being delimited by a first plug arranged distally in the multi-chamber carpule and a second plug arranged proximally therein; a mixing element is rotatably mounted about a rotational axis in relation to the housing and can be rotated about the rotational axis in a rotational direction in order to mix the active substance and the solvent; and a first detent device is provided on the device such that, after the mixing operation, an axial displacement of the distal end of the second plug in relation to the wall of the multi-chamber carpule is blocked in the proximal direction by means of the distal end of the bypass.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of International Application No. PCT / CH2016 / 00129 filed Oct. 4, 2016, which claims priority to Swiss Application No. 01508 / 15 filed Oct. 19, 2015, the entire contents of all of which are incorporated by reference herein in their entirety.BACKGROUND[0002]The invention relates to a device for administering an active substance and to a method for operating said device. The device comprises a multi-chamber carpule with a solid active substance and a solvent, and a mixing device for mixing the active substance and the solvent, wherein the mixing device comprises a mixing element and a bendable piston rod, which are coupled to one another.[0003]Such a device is used to make it possible for a solid substance that is unstable in a fluid to be mixed with a solvent only shortly before the administration and that can consequently be stored. Such devices are known from the prior art, for example, from WO2008 / 122132 ...

AI Technical Summary

Benefits of technology

The present invention provides a device for administering an active substance that can be easily and reliably handled after mixing a solid substance with a solution fluid. The device ensures a simple and reliable operation for aspirating and administering the dissolved active substance. The device includes a first detent device that prevents air and / or the dissolved active substance from reaching the area of the bypass of the multi-chamber carpule after the mixing operation. The first detent device ensures that the first plug and the second plug are always connected in an air-tight manner to one another. The device also includes a second detent device that prevents a mixing movement in the opposite direction during the mixing of the active substance and the solvent. The second detent device can include an indicator device that produces a detent sound. The device includes a bendable piston rod that ensures a short construction of the administration device. The piston rod can be formed as a band or spring and can be guided by a guide slot in the housing or in the holding device.

Problems solved by technology

In the case of administration of substituted coagulation factors in the form of a lyophilizate, in particular, the challenge is that after the dissolution of the lyophilized coagulation factor in a solvent and after sticking a cannula of an infusion set, which is attached to an administration device, into a vein of the patient, it must be possible to aspirate, that is to say, suction the venous blood through the cannula of the infusion set.

The disadvantage of the above-mentioned devices is that after the mixing operation of a solid active substance with a solvent, no reliable and simple handling of the aspiration and of the administration of the dissolved active substance can be ensured.

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