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Treatment of anxiety disorder and augmentation of Anti-anxiety interventions by administration of noble gas containing mixtures

a technology of noble gas and anti-anxiety, applied in the field of psychotic disorders, can solve the problems of increased blood pressure, shortness of breath, increased anxiety, etc., and achieve the effect of enhancing the efficacy of existing therapies for panic attacks

Inactive Publication Date: 2020-02-20
NOBILIS THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent text describes a method to enhance the effectiveness of therapies for panic attacks by administering a Noble Gas composition. The technical effect is to improve the treatment of panic attacks.

Problems solved by technology

This disproportionate response to environmental stimuli can hyperactivate the hypothalamic-pituitary-adrenal axis and the autonomic nervous system, resulting in somatic manifestation of anxiety, including shortness of breath, sweating, nausea, rapid heartbeat and elevated blood pressure (Sanford et al.
Individuals with GAD startle easily and may suffer from depression.

Method used

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  • Treatment of anxiety disorder and augmentation of Anti-anxiety interventions by administration of noble gas containing mixtures
  • Treatment of anxiety disorder and augmentation of Anti-anxiety interventions by administration of noble gas containing mixtures
  • Treatment of anxiety disorder and augmentation of Anti-anxiety interventions by administration of noble gas containing mixtures

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Embodiment Construction

[0082]The invention provides means of utilizing Noble Gas composition administered alone or as an adjuvant therapy to reduce panic attacks and / or generalized anxiety.

[0083]The fundamental finding, which to our knowledge is new, useful and non-obvious, is that administration of various concentrations of xenon gas containing gaseous compositions to patients suffering from panic disorders was associated with reduction of panic attacks, suppression of depressive behavior, and a post-treatment therapeutic effect.

[0084]In one embodiment of the invention, patients suffering from panic disorder are treatment by administration of Noble Gas containing compositions. Particularly, administration may be performed by inhalation of the gas, systemic administration, topical administration or administration into a bodily cavity. In a preferred embodiment administration of Noble Gas containing compositions is performed by inhalation several times per week of sub-anesthetic concentrations of Noble Gas...

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Abstract

Disclosed are compositions of matter, treatment methods, and combination therapies for addressing panic attacks in patients suffering from Panic Disorder (PD). In one embodiment the invention provides the use of Noble Gas containing mixtures at a sufficient concentration and frequency to prevent, and / or inhibit frequency of panic attacks. In one particular embodiment xenon gas is administered by inhalation of xenon-oxygen mixtures at concentrations ranging from 15% / 85% to 30% / 70% with xenon consumption is capped at 3.0 liters per procedure. In other embodiments xenon-oxygen or xenon-oxygen-nitrogen mixtures are administered at sub-anesthetic concentrations which are sufficient to elicit reduction in panic attacks and / or synergize with medications patients are receiving for panic / anxiety symptoms.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]The present invention claims priority to U.S. Provisional Application No. 62 / 414,831, filed Oct. 31, 2016, which is hereby incorporated in its entirety including all tables, figures, and claims.FIELD OF THE INVENTION[0002]The invention pertains to the field of psychiatric disorders, more particularly, the invention pertains to the field of panic attacks in patients suffering from panic disorder. Specifically, the invention pertains to utilization of Noble Gases to decrease Panic Disorders.BACKGROUND OF THE INVENTION[0003]Panic / anxiety is broadly defined as a state of unwarranted or inappropriate worry often accompanied by restlessness, tension, distraction, irritability and sleep disturbances. This disproportionate response to environmental stimuli can hyperactivate the hypothalamic-pituitary-adrenal axis and the autonomic nervous system, resulting in somatic manifestation of anxiety, including shortness of breath, sweating, nausea, rapid...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61P25/22
CPCA61P25/22A61K33/00A61K2300/00
Inventor BOGIN, VLADICHIM, THOMAS
Owner NOBILIS THERAPEUTICS INC