Pharmaceutical composition for treating thyroid cancer comprising tyrosine kinase activity inhibitor as active ingredient

a technology of tyrosine kinase and active ingredient, which is applied in the direction of drug compositions, antineoplastic agents, medical preparations, etc., can solve the problems of poor prognosis, high mortality, and rapid progression of thyroid cancer, and achieve the effects of killing thyroid cancer cells, promoting iodine uptake, and increasing the expression of sodium iodide symporter

Inactive Publication Date: 2020-08-06
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0010]The use of the composition according to one embodiment of the present disclosure may increase the expression of sodium iodide symporter in thyroid cancer cells, thereby promoting iodine uptake and killing thyroid cancer cells. Thus, the composition may be useful for the treatment of thyroid cancer.

Problems solved by technology

Anaplastic carcinoma is a rare, highly malignant undifferentiated tumor which is characterized by aggressiveness, rapid progression, a poor prognosis, and high mortality.

Method used

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  • Pharmaceutical composition for treating thyroid cancer comprising tyrosine kinase activity inhibitor as active ingredient
  • Pharmaceutical composition for treating thyroid cancer comprising tyrosine kinase activity inhibitor as active ingredient
  • Pharmaceutical composition for treating thyroid cancer comprising tyrosine kinase activity inhibitor as active ingredient

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Embodiment Construction

[0044]Hereafter, one or more embodiments will be described in more detail with reference to examples. However, these examples are merely to illustrate one or more embodiments, and the scope of the present disclosure is not limited to these examples.

Experimental Methods

[0045]1. Cell Culture

[0046]8505C cells, which are a human anaplastic thyroid cancer (hereinafter referred to as ATC) cell line, were cultured with RPMI-1640 medium (Hyclone) containing 10% fetal bovine serum (FBS; Gibco) and 1% penicillin-streptomycin (Hyclone) in a humidified incubator at 37° C. under 5% CO2.

[0047]2. Construction of pNIS-FL2-TurboFP635-pCMV-Rluc Recombinant Vector

[0048]A pNIS-FL2-TurboFP635-pCMV-Rluc recombinant vector expressing reporter genes driven by dual promoters was constructed by Cosmo Genetech Co., Ltd. (Republic of Korea) using a pNIS-FL2-TurboFP635 vector and a pcDNA3.1 / Hygro(+) vector. Specifically, in order to screen a substance that increases the activity of NIS promoter, Firefly-lucifer...

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Abstract

A pharmaceutical composition containing a tyrosine kinase activity inhibitor as an active ingredient may increase the expression of sodium iodide symporter in thyroid cancer cells, thereby promoting iodine uptake and killing thyroid cancer cells. Thus, the composition may be useful for the treatment of thyroid cancer.

Description

TECHNICAL FIELD[0001]The disclosure relates to a pharmaceutical composition for treating thyroid cancer containing a tyrosine kinase activity inhibitor as an active ingredient.BACKGROUND ART[0002]Thyroid cancer is the most common tumor of the endocrine system, and examples thereof include papillary carcinoma, follicular carcinoma, Hurtle cell neoplasm, anaplastic carcinoma (undifferentiated thyroid cancer), medullary thyroid carcinoma, and the like. Among these, differentiated tumors such as thyroid papillary carcinoma and thyroid follicular carcinoma show a relatively good prognosis, but in the case in which these tumors infiltrated the surrounding tissues or metastasized to other organs, the survival rate of patients with these tumors decreases rapidly. Anaplastic carcinoma is a rare, highly malignant undifferentiated tumor which is characterized by aggressiveness, rapid progression, a poor prognosis, and high mortality. Unlike differentiated thyroid cancer, anaplastic carcinoma d...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/519A61P35/04
CPCA61P35/04A61K31/519
Inventor AHN, BYEONG CHEOLOH, JI MIN
Owner KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND
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