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39 results about "Iodide sodium" patented technology

Novel route cefprozil compound

The invention provides a novel route cefprozil compound, which simplifies the processes of 7-phenylacetamide-3-chloromethyl cephalosporanic acid anisyl acetate and triphenylphosphine phyllocaline Benedict's reagents, and activating reagents such as sodium iodide and the like do not need to be added, so the post treatment is simple and convenient, the production amplification can be realized more easily, and at the same time, para hydroxybenzene glycine is adopted to react with 2, 4, 6-trichlorophenol to generate a novel intermediate product of para hydroxybenzene glycine 2, 4, 6- phenyl ester trichlorine. The stability and the activity of the compound are mild, by-products produced in the reaction are fewer, the reaction yield is improved, and in addition, the obtained products have high purity and low isomeride content.
Owner:HAINAN MEIDA PHARMA

Preparation method of melatonin

The invention relates to the technical field of chemical synthesis of medicines, in particular to a preparation method of melatonin. The preparation method of the melatonin comprises the following steps: (a) subjecting phthalimide, 1,3-dichloropropane, sodium iodide and ethyl acetoacetate to a reaction in a solvent under the action of alkali to obtain a compound I; (b) performing a ring closing reaction on the compound I and p-methoxyphenyl diazonium salt in the presence of alkali and a solvent to obtain a compound II; (c) hydrolyzing the compound II under an alkaline condition, and carrying out decarboxylating under an acidic condition to obtain a compound III; and (d) carrying out an acetylation reaction on the compound III to obtain melatonin. According to the preparation method, phthalimide, 1,3-dichloropropane, ethyl acetoacetate and the like are used as raw materials, and the price of the raw materials is low; the intermediate compound I can be obtained through a one-step method,so reaction steps and time are shortened; moreover, the conditions of each reaction step are relatively mild, the raw materials are easy to obtain, and high yield can be obtained.
Owner:浙江财和生物科技有限公司

Hydronopyl triethyl ammonium iodide preparation method and application

The invention relates to a preparation method of hydronopyl triethyl ammonium iodide, and an application of the prepared hydronopyl triethyl ammonium iodide in preparation of an inhibitor for treating tumor. The compound has obvious inhibition effect for tumor cells, and the preparation method of hydronopyl triethyl ammonium iodide is characterized in that hydronopyl chlorine is reacted to sodium iodide to prepare hydronopyl iodine, and the hydronopyl iodine is reacted to triethylamine to obtain hydronopyl triethyl ammonium iodide. The prepared hydronopyl triethyl ammonium iodide has median inhibitory concentration 50 (IC50 ) value of human lung cancer H460 cells, human breast cancer MCF7 cells, human liver cancer SMMC7721 cells, human stomach cancer MK-45 cells as 8.3mum g / ml, 13.25mum g / ml, 2.28mum g / ml and 1.27mum g / ml, which are most basically less than 10 mum g / ml, and partially achieves the requirements of SFDA antitumor drug pharmacodynamics guidance principle, and expresses good antineoplastic activity.
Owner:JIANGXI AGRICULTURAL UNIVERSITY

Metal halide lamp pill

InactiveCN103839751ARaise the ratioIncrease pipe wall loadingGas discharge lamp detailsIndiumIodide
The invention relates to a metal halide lamp pill. The metal halide lamp pill comprises scandium iodide, sodium iodide, thorium iodide, thallium iodide and indium iodide and further comprises lithium iodide and dysprosium iodide. The metal halide lamp pill comprises, by weight, 70-90 parts of scandium iodide, 10-20 parts of sodium iodide, 0.03-0.1 part of thorium iodide, 0.05-0.15 part of thallium iodide, 0.01-0.04 part of indium iodide, 0.05-0.15 part of lithium iodide and 0.05-0.10 part of dysprosium iodide. According to the metal halide lamp pill, the spectral component and proportion in plasma discharging are changed, and the proportion of visible light is increased. The tube wall load of an electric arc tube is improved, and the luminous flux of unit power is improved. According to a metal halide lamp manufactured through the metal halide lamp pill, the quality exceeds the national standard, and the metal halide lamp has the high light effect more than 120 Lm / w, the service life is more than 12000 hours, and the energy saving and environment protection purposes are achieved.
Owner:徐州润霖农牧发展有限公司

Novel synthesis method of Selinexor active pharmaceutical ingredient

The invention provides a novel synthesis method of a Selinexor active pharmaceutical ingredient. The method comprises the following steps: mixing a compound 6, dichloromethane and ethyl acetate, adding a compound 4, T3P and DIPEA (diisopropylethylamine) at low temperature, reacting, adding water and ethyl acetate, skimming, and drying up the organic phase by distillation to obtain a compound 7 crude product; mixing the compound 7, glacial acetic acid and sodium iodide, heating and reacting; after the reaction finishes, cooling, adding water and dichloromethane, standing to stratify, washing the organic phase, drying, and distilling to obtain a compound 8; mixing the compound 1, DBACO and DMF (N,N-dimethylformamide), dropwisely adding a compound 8 DMF solution, and reacting; and after the reaction finishes, adding water and ethyl acetate, drying up the organic phase by distillation, and recrystallizing to obtain the compound 5. The synthesis method solves the problem that the traditional synthesis technique can easily generate trans impurities, reduces the synthesis steps, enhances the yield, and provides a new technique for synthesizing the Selinexor active pharmaceutical ingredient.
Owner:广州市闻皓生物科技有限公司

Method for digitally correcting sodium iodide crystal decay time in real time

The invention provides a method for digitally correcting attenuation time of a sodium iodide crystal in real time. The method comprises but is not limited to steps that S1, after rays are detected bya detector composed of a sodium iodide crystal and a photomultiplier, the photomultiplier outputs a current pulse signal of an exponential decay function waveform, the signal is defined as I(t), and the decay time constant of the crystal is tau0; S2, after the current pulse signal I(t) is converted by an RC feedback type charge sensitive amplifier, a double-exponential voltage signal is formed, moreover, the bandwidth of an input current pulse signal is reduced, and the signal is defined as V(t); S3, digital sampling of the signal V(t) is conducted through an ADC, and a digital pulse signal V(n) is formed and enters an FPGA to be subjected to digital signal processing. The method is advantaged in that whole process of the method for digitally correcting the attenuation time of the sodium iodide crystal in real time is automatically carried out, and the attenuation time of the crystal changing in a large range is corrected in real time within a wide temperature range; a spectral line drift phenomenon of the energy spectrum measurement equipment caused by crystal attenuation time change is greatly reduced.
Owner:中广核久源(成都)科技有限公司

Thallium-doped sodium iodide scintillation crystal radiation detector with exit surface matched with lens group

InactiveCN110737015AOvercoming selectivityOvercome the inherent pitfalls of optimizationX/gamma/cosmic radiation measurmentImage resolutionScintillation crystals
The invention relates to a scintillation crystal radiation detector with a special light emitting surface matched with a lens group. A matched wide-angle and large-depth-of-field lens group is constructed, so the collection efficiency of the optical sensor on the scintillation light is improved and the energy resolution is improved. The specific parameter design considers the matching with the emergent wave band of the scintillation crystal, so the incident light sensor for focusing and collecting the scintillation light can be increased, the energy resolution is improved, the shape of the light emitting surface of the scintillation crystal matched with the lens group is correspondingly designed, the measurement efficiency and the measurement precision are further improved, and the detection performance can be further improved especially when a high-performance detector is developed.
Owner:左慈斌

Improved synthesis method of palladium complex

InactiveCN106243151AImproved synthesis method is simpleImproving the synthesis method is fastGroup 5/15 element organic compoundsOrganic-compounds/hydrides/coordination-complexes catalystsDichloromethaneChemistry
The invention discloses an improved synthesis method of a palladium complex (X in a general formula is equal to Br or I) and belongs to the field of organic chemistry. The improved synthesis method is characterized by including: using PdCl2(PPh3)2 and sodium iodide or sodium bromide as raw materials, wherein a feeding molar ratio is 1:10; using dichloromethane and water as solvents according to a volume ratio of 1:1, reacting to obtain a product, and subjecting the product to extracting, washing and filtering to obtain high-quality PdX2(PPh3) palladium complex. The palladium complex is high in yield, the method is simpler, the raw materials are cheaper, and the method has good industrial application prospect.
Owner:TIANJIN NORMAL UNIVERSITY

Process for Preparing Zanamivir and Intermediates for Use in the Process

The present invention provides a process for preparing methyl 5-acetamido-4-amino-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (V), which process comprises reducing methyl 5-acetamido-4-azido-6-(1,2,3-triacetoxypropyl)-5,6-dihydro-4H-pyran-2-carboxylate (IV) in the presence of a reducing agent selected from the group consisting of lithium aluminium hydride, sodium borohydride, zinc / ammonium chloride, zinc-ferric chloride and ferric chloride / sodium iodide. The present invention also provides compounds of formula (VIII) and (IX) which may be used in the synthesis of zanamivir. The present invention also provides processes for preparing compounds (VIII) and (IX) and processes involving their use, including in the synthesis of zanamivir.
Owner:CIPLA LTD

Triptolide prodrug as well as preparation method and medical application thereof

The invention discloses a triptolide prodrug as well as a preparation method and medical application thereof. Belongs to the field of pharmaceutical chemistry. The preparation method comprises the following steps: 1, reacting triptolide with acyl chloride under the action of DMAP to generate an intermediate II; 2, reacting the intermediate II with a carboxylic acid compound under the action of sodium iodide and potassium carbonate to generate a compound III; and 3, salifying the compound III and acid to obtain the target compound I. The derivative has better water solubility and pharmacokinetic properties, and compared with Minnelide, the derivative has a faster conversion speed in an in-vivo blood environment and a more efficient synthesis method, and has a better treatment effect on malignant tumors, inflammatory diseases, autoimmune diseases and the like; in addition; due to good water solubility, the compound is effective in oral administration and can be prepared into an injection for use.
Owner:NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE

A kind of preparation method of 1-bromoalkyne and 1-iodoalkyne

The invention discloses a preparation method of 1-bromoalkyne and 1-iodoalkyne. The preparation method comprises the following steps that terminal alkyne is adopted as a raw material, a chloramine salt and an iodine salt or a bromine salt is adopted as a halogenation system, and reaction is carried out in a solvent to synthesize a series of 1-bromoalkyne and 1-iodoalkyne type compounds. In the formula shown in the description, R in terminal alkyne is selected from chain-like alkyne, ring-shaped alkyne, olefin, ester group, cyanogroup, substituted phenyl group and heterocyclic arene; the chloramine salt is selected from one of chloramine B, chloramine T or o-chloramine T; the iodine salt is selected from one of sodium iodide, potassium iodide, ammonium iodide, lithium iodide or tetrabutylammonium iodide; the bromine salt is selected from one of sodium bromide, potassium bromide, lithium bromide, magnesium bromide, ammonium bromide or tetrabutylammonium bromide; the solvent is selected from one or is mixed by two of water, benzene, methylbenzene, 1, 4-dioxane, ethyl acetate, dimethyl sulfoxide, methanol, tetrahydrofuran, alcohol, isopropyl alcohol, N, N-dimethyl formamide, n-pentane,dichloromethane, petroleum ether, methyl tert-butyl ether, chloroform, n-hexane, carbon tetrachloride, n-butyl alcohol, 1,2-dichloroethane or acetonitrile. The preparation method disclosed by the invention has the beneficial effect that the application is wide.
Owner:ZUNYI MEDICAL UNIVERSITY

Pharmaceutical composition for treating thyroid cancer comprising tyrosine kinase activity inhibitor as active ingredient

A pharmaceutical composition containing a tyrosine kinase activity inhibitor as an active ingredient may increase the expression of sodium iodide symporter in thyroid cancer cells, thereby promoting iodine uptake and killing thyroid cancer cells. Thus, the composition may be useful for the treatment of thyroid cancer.
Owner:KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND

Sodium-iodide symporter gene repressor binding site

The present disclosure relates to a sodium iodide symporter (NIS)-repressor binding sites (NRBS) consensus sequence consisting of a DNA molecule having the sequence 5′-T / C(G / A)GCCT(T / C)A(G / A)TTTCCCCA(T / C)CTGT-3′(the “consensus NRBS”). The disclosure further relates to methods of restoring iodide transport in dedifferentiated thyroid cancer cells by interfering with formation or function of the NIS repressor.
Owner:UNIV OF KENTUCKY RES FOUND

A kind of preparation method of ticagrelor key intermediate iodide

A preparation method of ticagrelor key intermediate iodide, comprising the following steps: (1) synthesis of intermediate 1, (3) synthesis of key intermediate iodide, the synthesis of described intermediate 1 is based on D- Ribose is used as a raw material, methanol and acetone are used as a solvent, thionyl chloride is added as a catalyst, and the solvent is concentrated and removed after the reaction to obtain the intermediate 1; the synthesis of the key intermediate iodide uses acetonitrile as a solvent, and the Intermediate 1. Sodium iodide is added to the reaction system, trimethylchlorosilane is added dropwise, a small amount of water is added after the reaction is completed to quench the reaction, acetonitrile is evaporated, solvent extraction, and concentration to obtain the key intermediate iodide. In the preparation method of ticagrelor key intermediate iodide of the present invention, in the synthesis process of intermediate 1, thionyl chloride is used instead of hydrochloric acid as a catalyst, the reaction conversion rate is greatly improved, and then trimethylchlorosilane is used as a catalyst. / Sodium iodide is used as an iodinating agent, the reaction conditions are mild, the post-treatment is simple and the conversion rate is high.
Owner:苏州诚和医药化学有限公司

Comprehensive efficient centrifugal machine for sodium iodide production

InactiveCN113385311AIncrease the speed of layeringImprove centrifugation efficiencyCentrifugesDrive shaftElectric machinery
The invention discloses a comprehensive efficient centrifugal machine for sodium iodide production. The comprehensive efficient centrifugal machine for sodium iodide production comprises a tank body, a tank cover and a fine-hole filter screen, the bottom of the front end of the tank body communicates with a discharge valve which is obliquely distributed, the tank cover is installed at the top of the tank body, a driving motor which is vertically distributed is installed at the bottom of the tank body, a transmission shaft is in transmission connection with the top of the driving motor and located on the inner side of the tank body, and the fine-hole filter screen is fixedly connected to the middle of the transmission shaft. According to the comprehensive efficient centrifugal machine for sodium iodide production, firstly, a comprehensive centrifugal structure is adopted, a solution can be subjected to comprehensive drainage and centrifugal separation operation, the solid-liquid layering rate is increased, and therefore the solid-liquid centrifugal separation efficiency of the solution is improved, secondly, a lifting and filtering type slag discharging structure is adopted, solid impurities obtained after centrifugal separation can be rapidly filtered out of the solution, conveyed and collected in a centralized mode, and the participation of a procedure of manually separating and filtering solid impurities is reduced, so that the production efficiency of the sodium iodide is improved.
Owner:潘翔宇

Improved preparation method of penicillin hydriodate

The invention relates to the field of pharmacy, and particularly provides an improved preparation method of penicillin hydriodate, which comprises the following steps: 1) dissolving penicillin citrate with water, then adding a sodium iodide or potassium iodide solution for reaction, growing crystals, filtering, washing and drying to obtain the penicillin hydriodate. The method disclosed by the invention has the advantages of high yield, easiness in operation and small toxicity, the reaction condition is mild, the product purification, intermediate storage and impurity control are facilitated, and the penicillin hydriodate product with good stability is obtained.
Owner:内蒙古联邦动保药品有限公司

Composition capable of healing herpes and preparation method of same

The invention discloses a composition capable of healing herpes and a preparation method of same. The composition includes, by weight, 50-70 parts of cimetidine, 10-20 parts of corn starch, 15-20 parts of poria cocos powder, 10-20 parts of lauryl sodium sulfate, 5-10 parts of mannitol, 2-5 parts of magnesium stearate, 20-30 parts of purified water, 1-3 parts of carboxymethyl starch sodium, 1-3 parts of acetanilide, 3-7 parts of sodium methoxide, 1-3 parts of sodium iodide, 2-3 parts of AlCl3, 15-20 parts of inosine, 5-10 parts of methyl triazolecarboxylate, 10-15 parts of diethylamine, 5-8 parts of stearic acid, 1-2 parts of glyceryl monostearate, 1-4 parts of pure Vaseline, 3-8 parts of ethylparaben, 1-5 parts of chlortrimeton powder, 10-20 parts of liquid paraffin, 10-15 parts of triethanolamine and 5-10 parts of azone. The product can treat herpes, herpes simplex, and deficiency of potassium, and local touch pain and stabbing pain of skin of whole body, and facial eczema. The product can reduce the types of medicines that a patient needs to take and reduces treatment cost of the patient.
Owner:肖耀刚

Thallium-doped sodium iodide scintillation crystal radiation detector with high light extraction rate

The invention relates to a scintillation crystal radiation detector with the high light extraction rate. According to the invention, the conception of designing the film layer in a targeted manner iscarried out aiming at the main emergent waveband of the scintillation crystal, the difficulty that the film research data volume is too large and is difficult to analyze is overcome, and a proper reflective film layer material is obtained; the detector has good adhesion with the crystal, the film layer number is less and is easy to realize, and the measurement efficiency and the measurement precision are correspondingly improved.
Owner:刘娟

A kind of synthetic method of rhodium-platinum core-shell bimetallic nanowire

The invention discloses a method for synthesizing rhodium-platinum core-shell bimetallic nanowires. Ethylene glycol is used as a reaction solvent, sodium iodide dihydrate is used as a complexing agent, polyvinylpyrrolidone is used as a surfactant, and sodium ascorbate is used as a weak reducing agent. , Sodium hexachlororhodiumate dodecahydrate is the source of rhodium, and chloroplatinic acid hexahydrate is the source of platinum. In the present invention, rhodium-platinum with controllable components, high specific surface area, high durability, high resistance to CO poisoning, and rich defect sites is prepared by first preparing rhodium nanowire seed crystals, and then depositing them with a simple and green chemical method. Core-shell bimetallic nanowire materials.
Owner:HUAQIAO UNIVERSITY

A kind of preparation method of improved sacillin hydroiodide

The present invention relates to the field of pharmacy, and specifically provides an improved method for preparing salsacillin hydroiodide, the method comprising 1) dissolving salsacillin citrate in water, then adding sodium iodide or potassium iodide solution to react, and growing crystals , filtered, washed and dried to obtain sacillin hydroiodide. The method of the invention has the advantages of high yield, easy operation and low toxicity, mild reaction conditions, is beneficial to product purification, intermediate storage and impurity control, and can obtain a sacillin hydroiodide product with good stability.
Owner:内蒙古联邦动保药品有限公司

Thallium-doped sodium iodide scintillation crystal radiation detector with lens group

InactiveCN110837101AOvercoming selectivityOvercome the inherent pitfalls of optimizationRadiation intensity measurementImage resolutionScintillation crystals
The invention relates to a scintillation crystal radiation detector with a lens group. A matched wide-angle and large-depth-of-field lens group is constructed, the collection efficiency of an opticalsensor on scintillation light is improved, the energy resolution is improved, the specific parameter design considers the matching with an emergent wave band of a scintillation crystal, an incident light sensor after the scintillation light is focused and collected can be increased, the energy resolution is improved, the measurement efficiency and the measurement precision are correspondingly improved, and particularly, the detection performance can be further improved when a high-performance detector is developed.
Owner:魏海清

Process for growing large-size cesium iodide crystal by Czochralski method

The invention discloses a process for growing a large-size cesium iodide crystal by a Czochralski method. The method comprises the following steps: charging, seeding, necking, shouldering and equal-diameter growth. The shouldering step is carried out by controlling the cooling rate of a shouldering stage to be 2-4 DEG C / 30min and the duration to be 30-40 min, continuously adjusting the heating power, keeping the heating power unchanged, and cooling the crystal at a low cooling rate of 2-4 DEG C / 2h under the condition that the rotating speed and the pulling speed are unchanged, wherein the crystals can be ended after growing to a preset length;, generally, the crystals are rapidly lifted until the crystals are completely separated from the melt, a slow cooling method is adopted to eliminatestress formed in the crystals during high-temperature growth, a power supply can be turned off when the working voltage is reduced to 50 V, and circulating cooling water is turned off when the furnace temperature reaches the room temperature. According to the process for growing the large-size cesium iodide crystal by adopting the Czochralski method, the cesium iodide is used for replacing sodiumiodide, and the Czochralski method is adopted for growth, so that the impact resistance of the detector is improved, and meanwhile, the cost is saved.
Owner:BEIJING SHENGTONGHEJING SCI & TECH

Preparation method of 5-amino-2-azaspiro [3.4] octane-2-carboxylic acid tert-butyl ester

InactiveCN112574085AMethod route shortReaction amplificationOrganic chemistryPtru catalystEthylic acid
The invention discloses a preparation method of a compound 5-amino-2-azaspiro [3.4] octane-2-carboxylic acid tert-butyl ester. The preparation method comprises the following steps: 1. dissolving a compound 1 and a compound 2 in 2-methyl tetrahydrofuran, dropwisely adding lithium bis (trimethylsilyl) amide, and reacting to obtain a compound 3; 2, dissolving the compound 3 into acetone, and reactingwith sodium iodide to obtain a compound 4; 3, dissolving the compound 4 in 2-methyl tetrahydrofuran, dropwise adding n-butyllithium, and reacting to obtain a compound 5; 4, adding the compound 5 andamine into 1, 2-dichloroethane, then adding acetic acid and a reducing agent, and reacting to obtain a compound 6; and 5, dissolving the compound 6 in ethanol, adding a catalyst, and reacting in hydrogen to obtain a compound 7. The novel spiro compound structure is designed autonomously, a synthetic route is developed, and a synthetic method suitable for industrial production is found through continuous optimization.
Owner:南通药明康德医药科技有限公司

Transcriptional repression of sodium-iodide symporter in thyroid carcinoma

The present disclosure relates to a sodium iodide symporter (NIS)-repressor binding site (NRBS) consisting of a DNA molecule spanning from −645 to −605 nucleotides (SEQ ID NO:4) or from −648 to −620 nucleotides (SEQ ID NO:5) upstream from the translation start site of human NIS gene. The disclosure further relates to a method of restoring iodide transport to a human thyroid carcinoma cell, including: the steps of: i) contacting the cell expressing and forming a NIS repressor protein complex capable of binding to the NRBS of the disclosure with a modulator of said complex, and ii) administering to the cell radiolabeled iodide.
Owner:UNIV OF KENTUCKY RES FOUND

Modified sodium iodide symporter proteins and uses thereof

A modified sodium iodide symporter (NIS) protein is provided. The modified NIS protein comprises an amino acid sequence of SEQ ID NO.1 with the proviso that at least one amino acid residue within SEQ ID NO. 1 is changed. The modified NIS protein has an enhanced transport function, and the expression of the modified NIS protein in the cells results in higher intracellular levels of a substrate of a NIS protein than does the expression of the same amount of a wild-type NIS protein.
Owner:CHINA MEDICAL UNIVERSITY(TW)
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