Process for preparation of grapiprant
a technology of grapiprant and process, which is applied in the field of process for the preparation of grapiprant, can solve the problems of inability to scale up and commercialize production, and the isolation of column chromatography or such techniques is not suitable for the scale up and commercial production, and is feasible only at laboratory scal
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example 1
on of Compound of Formula (VI)
[0118]In a 500 mL round bottom flask, a solution of compound of Formula (VII) (10 gm, 53.6 mmol) in N-methyl-2-pyrrolidone (17.5 ml) was heated to about 70-75° C. Another solution of compound of Formula (VIII) (7.0 gm 51.03 mmol) was prepared in N-methyl-2-pyrrolidone (10 ml) and added to the above reaction mass. Reaction was maintained at 80-100° C. for 2 hours. After completion of the reaction, it was cooled to the ambient temperature and ethyl acetate was added into the reaction mass. The reaction mass was stirred for an hour at ambient temperature and filtered and washed with ethyl acetate. The product was dried to obtain 2-(4-((2,6-dimethyl-3-nitropyridin-4-yl)amino)phenyl)ethan-1-ol hydrochloride i.e compound of Formula (VI)(15.5 gm, yield 94%).
example 2
on of Compound of Formula (V)
[0119]In 500 mL round bottom flask, a solution of compound of Formula (VI) (30 gm) in methanol (150 ml) was added. Raney Nickel (6 gm, 50% wet) was added and the reaction mass was heated to about 60-70° C. and hydrazine hydrate (80%, 29.1 gm) was added to the reaction mass dropwise. The reaction mass was then maintained at 60-70° C. for 2-4 hours. After completion of the reaction, the reaction mass was cooled to ambient temperature and catalyst was filtered on celite pad and washed with methanol. The solvent was then distilled off under vacuum to obtain a residue. The residue was then dissolved in methanol and then heated to about 50-55° C. and then ethyl acetate was added. The reaction mass was then cooled to 20-30° C. and stirred for one hour. The solids were then filtered and dried to obtain compound of Formula (V) (23.4 gm, yield 98.7%).
example 3
on of Compound of Formula (IV)
[0120]In 500 mL round bottom flask, a mixture of propionic acid (42 ml) and propionic anhydride was added. Compound of Formula (V) (21 gm, 81.6 mmol) was then added to the above reaction mass and heated to about 110-120° C. The reaction mass was stirred for about 6-8 hours and then after completion of the reaction, the reaction mass was cooled to 25-35° C. 25% aqueous sodium hydroxide solution (185 gm) was added and then heated to 60-70° C. and maintained for 8 hours. After completion of reaction the reaction was cooled to ambient temperature and filtered and washed with water and dried to obtain compound of Formula (IV). (16.9 gm, yield 70%).
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