Methods of using macrocyclic modulators of the ghrelin receptor

a macrocyclic modulator and receptor technology, applied in the field of using macrocyclic modulators of the ghrelin receptor, can solve the problems of increasing ghrelin levels, lack of efficacy, and disappointing agents
USRE42624E1Inactive Publication Date: 2011-08-16OCERA THERAPEUTICS INC
10 Cites 17 Cited by

Patent Information

Authority / Receiving Office
US · United States
Patent Type
Patents(United States)
Current Assignee / Owner
OCERA THERAPEUTICS INC
Publication Date
2011-08-16
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention provides novel conformationally-defined macrocyclic compounds that have been demonstrated to be selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and / or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.
Need to check novelty before this filing date? Find Prior Art

Description

RELATED APPLICATION INFORMATION

[0001] This application is a reissue of U.S. patent application Ser. No. 11 / 149,512, filed Jun. 10, 2005, now U.S. Pat. No. 7,491,695, which is a continuation-in-part under 35 U.S.C. § 120 of U.S. patent application Ser. No. 10 / 872,142, filed Jun. 18, 2004, currently pendingnow U.S. Pat. No. 7,521,420, which claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application Ser. No. 60 / 479,223, filed Jun. 18, 2003. This continuation-in-partreissue application also claims the benefit under 35 U.S.C. § 119(e) of U.S. Provisional Patent Application Ser. No. 60 / 621,642, filed Oct. 26, 2004, U.S. Provisional Patent Application Ser. No. 60 / 622,05560 / 622,005, filed Oct. 27, 2004, and U.S. Provisional Patent Application Ser. No. 60 / 642,271, filed Jan. 7, 2005. The disclosures of the above-referenced applications are incorporated herein by reference in their entireties.FIELD OF THE INVENTION

[0002] The present invention relates to novel conformatio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More