71results about How to "Avoid regulation" patented technology

The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The present invention also provides the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, as a single agent therapy for the treatment, prevention, management, or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chronic lymphocytic leukemia or non-Hodgkin's lymphoma, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

The present invention relates to antibodies or fragments thereof that specifically bind the extracellular domain of FcγRIIB, particularly human FcγRIIB, and block the Fc binding site of human FcγRIIB. The invention provides methods of treating cancer and / or regulating immune complex mediated cell activation by administering the antibodies of the invention to enhance an immune response. The invention also provides methods of breaking tolerance to an antigen by administering an antigen-antibody complex and an antibody of the invention.

The present invention relates to nucleic acid sequences and amino acid sequences which influence bone deposition, the Wnt pathway, ocular development, tooth development, and may bind to LRP. The nucleic acid sequence and polypeptides include Wise and Sost as well as a family of molecules which express a cysteine knot polypeptide. Additionally, the present invention relates to various molecular tools derived from the nucleic acids and polypeptides including vectors, transfected host cells, monochronal antibodies, Fab fragments, and methods for impacting the pathways.

The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The present invention also provides the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, as a single agent therapy for the treatment, prevention, management, or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chronic lymphocytic leukemia or non-Hodgkin's lymphoma, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

A tethered unmanned aerial system (UAS) is described, wherein the flight of one or more UASs may be used in connection with a water and light display.

An implant delivery syringe includes a barrel, a plunger assembly, and a barrel adapter. A barrel adapter mountable to a syringe barrel includes a barrel tip, needle retraction mechanism, needle assembly and stylet slidably disposed within the needle lumen. The needle retraction mechanism includes a biasing member, actuable locking arrangement and locking mechanism. When the actuable locking arrangement is actuated, the biasing member causes the needle to axially translate over the stylet during retraction to cause delivery of an implant to a target location. The stylet may be retracted following delivery. Methods of assembling, manufacturing, and using are also provided.

The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

The present invention relates to antibodies or fragments thereof that specifically bind the extracellular domain of FcγRIIB, particularly human FcγRIIB, and block the Fc binding site of human FcγRIIB. The invention provides methods of treating cancer and / or regulating immune complex-mediated cell activation by administering the antibodies of the invention to enhance an immune response. The invention also provides methods of breaking tolerance to an antigen by administering an antigen-antibody complex and an antibody of the invention.

The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.

One embodiment of the present invention provides an energy-management system for managing energy within a predominantly closed power system. During operation, the system obtains one or more control actions that control energy transitions of a plurality of components, receives transitional characteristics associated with the components, and schedules the energy transitions by generating a set of offsets. A respective offset results in a delay of at least one energy transition.

The invention proposes a generator set primary frequency modulation performance testing method for simulating grid frequency change, which comprises the following steps: arranging a frequency difference analog module and a selecting module in a generator set frequency control loop; selecting grid disturbance frequency change data ; setting the frequency difference analog module according to the data so as to enable the frequency difference analog module to simulate the frequency change during grid disturbance and to send a frequency difference signal; and allowing the selecting mode to break a frequency signal of the actual set, access the analog frequency difference signal sent by the analog module so as to test the primary frequency modulation performance of the generator set and record test process data. The method enables the primary frequency modulation of the generator set to meet the actual requirements of a grid, improves the electric energy quality of the grid, avoids the unnecessary regulation effect and saves the resources of the generator set.

System for detection and analysis of gas samples in fieldable real-time Differential Mobility Spectrometry (DMS) chemical sensor system which uses non-radioactive ion source for monitoring and detecting NOx emissions; provides reliable methods for detecting and monitoring of anthropogenic sources of NOx; also detection of NO in exhaled breath for patient health diagnosis.

Paper or cardboard machine and method for regulating a basis weight of a paper or cardboard web in the manufacturing process. The paper or cardboard machine includes at least one headbox that extends across a machine width. The at least one headbox is adapted to provide a machine-wide distribution of a material suspension onto one of a screen and between two screens. The machine also includes at least one material suspension supply coupled to the at least one headbox and adapted to supply a material suspension to the at least one headbox. The at least one material suspension supply has at least one concentration. At least one first control loop is provided that includes at least one actuator being adapted to adjust the at least one concentration of the at least one material suspension supply, at least one detector for determining a basis weight of a finished web, at least one supply being adapted to modify the at least one concentration of the at least one material suspension supply, and at least one device that adjusts the at least one actuator. In this manner, the at least one concentration of the at least one material suspension supply is adjusted. At least one second control loop is provided that is adapted to regulate the concentration of the material suspension supply. The method includes determining a basis weight at an end of the manufacturing process, calculating a deviation of the determined basis weight from a predetermined target value, adjusting a concentration of a material suspension supplied to a headbox via a first control loop such that the calculated deviation is corrected, one of directly and indirectly measuring a basis weight of a resulting web in a region upstream, with regard to a web travel direction, a drying section, and supplying a signal related to the measured basis weight to a second control loop.

A surround sound audio processing system includes a source that supplies a first signal for producing a first sound impression and a second signal for producing a second sound impression. A processing unit modifies the first signal and the second signal to produce a third sound impression of a virtual source, and provides first and second modified signals indicative thereof. The processing unit modifies the first signal and the second signal relative to each other such that the first and second modified signals have a phase shift of between 170° to 190°.

The invention discloses a paper indexing system based on a block chain technology. According to the system, an information distributed storage, non-tampering, traceable and excitable blockchain platform is used as a bottom architecture, and the blockchain platform of the system is connected with four functional modules, including a paper data storage module, a paper hierarchical sharing module, anintelligent recommendation module and a paper feedback evaluation module; wherein data sources of the paper data storage module comprise authors, periodicals, manuscript reviewers and referers, and the paper data storage module is used for storing full-process information of each piece of paper from writing, submitting, manuscript reviewing, publishing, referencing and feeding back; the method has the advantages that the blockchain technology is utilized, the full life cycle of writing, submitting, reviewing, publishing, quoting and feeding back of each paper can be public and transparent, paper experiment data are public, transparent, credible and traceable, academic achievement counterfeiting can be effectively avoided, the paper index speed can be increased, and paper can be effectively supervised.

The invention, which belongs to the new energy material and device field, especially relates to a back contact structure of a cadmium telluride thin-film solar cell, a solar cell, a cell assembly, and a preparation method. According to the technical scheme, the back contact structure that is arranged between a cadmium telluride absorption layer and a back electrode layer is a mixture layer with molybdenum nitride and molybdenum oxide; and the structure is expressed by (1-A) molybdenum nitride-A molybdenum nitride, wherein the A is larger than 0 and is less than 1. The work function of MoOy is high and the conductivity of MoNx is good; and thus, on the basis of combination of the MoOy material and the MoNx material, the back contact material can have advantages of the two kinds of materials.