The invention relates to a tissue box capable of rapidly switching locking modes, which comprises a box body and a flip cover, a locking module is arranged between the box body and the flip cover, the locking module comprises a button opening and closing mode and a key opening and closing mode, and a switcher for switching the button opening and closing mode and the key opening and closing mode is arranged on the locking module. The switcher is detachably connected with the locking module, and the locking module is detachably connected with the box body. By the adoption of the technical scheme, the switcher is inserted into the locking module in different scenes so that the two opening and closing modes of button opening and closing and key opening and closing can be switched, when the locking module is damaged, the locking module and the box body can be detached for replacement, the service life is long, and when the key opening and closing mode serves as a common mode, the operation is convenient. The roll paper in the tissue box is prevented from being taken away by people to cause loss and increase the operation cost and management difficulty of a management party, operation is easy, use is convenient, button and key opening and closing are integrated, applicability is higher, operation is convenient, the structure is simplified, cost is reduced, and popularization and consumption are easier.