The application discloses an
autism auxiliary diagnosis method and
system based on
gene pathway atlas information, and belongs to the
cross field of
bioinformatics and
machine learning. The application firstly reads original
sequencing data and pre-processes to obtain a standardized
differential expression gene matrix; introduces pathway function and
topological information, constructs a pathway topological
adjacency matrix, and dimensionally reduces a pathway
feature matrix, transmits a graph
signal, and encodes features to obtain
gene pathway features; then, the initial training of a multi-
modal fusion network is carried out on the foregoing two matrices; Top K
key genes are screened according to a gene importance
score, and secondary training is carried out in combination with the
gene pathway features; finally, the
gene expression of a to-be-detected object is input, and an
autism auxiliary
diagnosis classification result is output. The application introduces the
gene pathway atlas as prior knowledge, constructs a multi-
modal fusion network with biological
interpretability and high robustness, and can improve the
autism diagnosis accuracy based on a small number of key features.