The invention relates to the technical field of health products, and in particular relates to a lucid ganoderma refined powder compound soft capsule and a preparation method thereof. The lucid ganoderma refined powder compound soft capsule comprises 1 to 300 parts of lucid ganoderma refined powder, 1 to 50 parts of lycopene, 1 to 50 parts of grifolan, and 1 to 500 parts of safflower oil. According to the lucid ganoderma refined powder compound soft capsule, the lucid ganoderma refined powder, lycopene, grifolan and safflower oil which are different in molecular structure are used in common and have some same pesticide effects and also have individual outstanding pesticide effects; and after being organically combined in proportion, the four materials complement and promote one another on curative effect and maximize the effects individually. A preparation in form of the soft capsule can cover the discomfort smell of the contents and effectively improve the stability of the lycopene and safflower oil, enables quick and complete intake and absorption of the healthcare components, and give full play to inflammation resistance, pain alleviating, poisonousness reducing, wound repair promoting, immunoregulation, tumor inhibition, resisting to cancer, three highs (high blood pressure, high blood sugar and high blood lipid) and cardiovascular disease, senescence delaying, improvement of liver function, organism balancing and adjusting and other effects.