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Water soluble polylactic-acid material, prepn. method and application thereof

A water-soluble poly-lactic acid technology, applied in the field of biomedical materials, can solve the problems of long reaction time, high volatility, limited application, etc., and achieve the effects of simple method, high hydrophilicity, and improved biocompatibility

Inactive Publication Date: 2007-09-05
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 3. The required reaction time is very long;
[0007] 4. The preparation of some clathrates requires the use of organic solvents, which are often toxic and highly volatile, which is not conducive to in vivo applications;
[0008] 5. No polylactic acid materials involved
[0010] Since the pure polylactic acid material can only be dissolved in organic solvents, it is very limited when used as a biomedical material, especially as a drug carrier, especially as a DNA carrier material in the field of biologically active protein drugs and genetic engineering. Have a serious impact on the activity and specific molecular configuration of the drug
In addition, the residue of organic solvents will also have adverse consequences on the in vivo application of the material, which also limits the application of the material as a tissue engineering scaffold.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1) Weigh 2 g of polylactic acid with a viscosity-average molecular weight of 500,000 and dissolve it in 10 ml of methylpyrrolidone;

[0032] 2) Weigh 0.5g of β-cyclodextrin and dissolve it in 10ml of methylpyrrolidone;

[0033] 3) Add the β-cyclodextrin solution into the polylactic acid solution, mix and stir;

[0034] 4) Heating the mixed solution to 80°C under continuous stirring, and oscillating for 1 hour under the ultrasonic power of 50W;

[0035] 5) Cool the reaction product to 4°C, concentrate it using ultrafiltration technology, and then dialyze against water to remove the methylpyrrolidone solvent and unreacted β-cyclodextrin;

[0036] 6) The product is freeze-dried (freeze-drying conditions: the product is pre-frozen at a temperature lower than 0°C for 1 hour, and placed in a freeze dryer to freeze-dry), and about 0.25 g of β-cyclodextrin and polylactic acid inclusion complex in the form of blocks can be obtained thing;

[0037] 7) After drying, the product...

Embodiment 2

[0039] 1) Weigh 1000g of polylactic acid with a viscosity-average molecular weight of 10000 and dissolve it in 10L of methylpyrrolidone;

[0040] 2) Weigh 100g of α-cyclodextrin and dissolve it in 1L of methylpyrrolidone;

[0041] 3) After mixing the above two solutions, heat to 60°C, under the condition of 200W ultrasonic power, shake and react for 1h;

[0042] 4) Cool the reaction product to room temperature, put it into a dialysis bag and dialyze against water (the water volume is more than 10 times the sample volume, change the water once every half hour) for 10 hours, and remove the methylpyrrolidone solvent and unreacted α-cyclodextrin ;

[0043] 5) After dialysis, the solution is spray-dried to obtain 1100g of inclusion complex materials of α-cyclodextrin and polylactic acid in the form of powder;

[0044] 6) After drying, the product is added with water to make a paste, which can be used as tissue filling material, soft tissue filling material or dental material.

Embodiment 3

[0046] 1) Weigh 100 g of polylactic acid with a viscosity-average molecular weight of 100,000 and dissolve it in 1 L of methylpyrrolidone;

[0047] 2) Weigh 1g of γ-cyclodextrin and dissolve it in 10mL of methylpyrrolidone;

[0048] 3) After mixing the above two solutions, heat to 40°C, under the condition of 100W ultrasonic power, shake and react for 4h;

[0049] 4) Put the reaction product into a dialysis bag and dialyze against water (the amount of water is more than 10 times the sample volume, and change the water every half hour) for 10 hours to remove the methylpyrrolidone solvent and unreacted γ-cyclodextrin;

[0050] 5) After dialysis, the solution is spray-dried to obtain about 100 g of powdery clathrate material of γ-cyclodextrin and polylactic acid.

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PUM

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Abstract

A water-soluble polylactic acid used for the scaffold or filler in tissue engineering is prepared through dissolving polylactic acid in methylpyrrolidone to obtain solution A, dissolving cyclodextrin in methylpyrrolidone to obtain solution B, mixing A with B, stirring while heating, ultrasonic treating, cooling, ultra-filtering or dialysis to water for removing free cyclodextrin and solvent, and drying. It has high biocompatibility.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a water-soluble polylactic acid material and its preparation method and application. Background technique [0002] The existing polylactic acid modification mainly focuses on several aspects: the doping and blending of polylactic acid and other hydrophilic materials, such as the composite of polylactic acid and chitin, collagen, hydroxyapatite, calcium phosphate and other materials ; Graft modification of polylactic acid, such as graft copolymerization of polylactic acid and hydrophilic polymer materials polyethylene glycol, polyvinyl alcohol, polyethylene oxide, propylene oxide and other materials; surface coating technology of polylactic acid materials, For example, albumin, collagen, fibronectin and laminin are coated on the surface. [0003] In foreign literature, there are reports about cyclodextrin compounded with polyvinyl alcohol, polymethylsi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G63/06A61K6/087A61L31/06A61K6/891
Inventor 谢德明杨凯声
Owner JINAN UNIVERSITY
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