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Chinese medicine extract with function of reducing blood-sugar and preparing method

An extract and hypoglycemic technology, which is applied in the treatment of diabetes and its complications, and in the field of components for the treatment of diabetes and its complications, can solve problems that do not involve continuous separation methods of macroporous resins and ion exchange resins, and achieve feasible results and reliable effect

Inactive Publication Date: 2008-01-16
原爱红 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Another example is related to the separation of mulberry leaf polysaccharide in the Chinese Patent Publication No. CN1351085A, the extraction and separation method adopts organic solvent and ion exchange resin, and does not involve the continuous separation method of macroporous resin and ion exchange resin

Method used

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  • Chinese medicine extract with function of reducing blood-sugar and preparing method
  • Chinese medicine extract with function of reducing blood-sugar and preparing method

Examples

Experimental program
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Effect test

Embodiment 1

[0048] 1 kg of mulberry leaves, add 5-10 times the volume of deionized water, extract 3 times at 100 ° C, each time for no less than 20 minutes, combine the extracts, filter the residue from the extracts to obtain filtrate 1, and then remove the precipitate. The precipitation removal process adopts the flocculation process, that is, when the extracted filtrate 1 is concentrated to 1 / 10 of its original volume, chitin or clarifying agent is added, and after being incubated at 70-80°C for 5-6 hours, the precipitation is removed by centrifugation to obtain the filtrate 2. Pass the filtrate 2 through AB-8 macroporous resin at a flow rate of 5ml min -1 , eluted with deionized water until no precipitation when 95% ethanol was added to the eluent, concentrated the eluent to 1 / 4 volume and then added 95% ethanol to make the final concentration of ethanol reach 70%, filtered after standing overnight, The precipitate was repeatedly eluted with ethanol and acetone until the eluent was col...

Embodiment 2

[0052] 500 g of mulberry leaves and mulberry branches are mixed together for a total of 1 kg, add 7 times the volume of 50% methanol, and keep at 25 ° C. A total of 3 times, the filtrate was combined, concentrated, centrifuged, and the precipitate was removed, and the supernatant was passed through AB-8 macroporous resin at a flow rate of 5ml min -1 , eluted with deionized water until no precipitation when 95% ethanol was added to the eluent, concentrated the eluent to a certain volume and then added 95% ethanol to make the final concentration of ethanol reach 75%, filtered after standing overnight, and used for precipitation Ethanol and acetone were repeatedly eluted until the eluent was colorless, and dried at low temperature to obtain component 1, 8.4g, which was proved to be a polysaccharide component by qualitative identification experiments including test tube method and thin layer chromatography; then followed by 30 %, 50%, 70%, 90% ethanol to elute the macroporous resi...

Embodiment 3

[0054] Each 500g of mulberry branches and Morus alba bark is 1kg in total, 10 times the volume to remove 30% ethanol, 70°C. A total of 3 times, the filtrate was combined, concentrated, centrifuged, and the precipitate was removed, and the supernatant was passed through D101 macroporous resin at a flow rate of 5ml min -1 , eluted with deionized water until no precipitation when 95% ethanol was added to the eluent, concentrated the eluent to a certain volume and then added 95% ethanol to make the final concentration of ethanol reach 80%, filtered after standing overnight, and used for precipitation Ethanol and acetone were repeatedly eluted until the eluent was colorless, and dried at low temperature to obtain component 1, 9.4g, which was proved to be a polysaccharide component by qualitative identification experiments including test tube method and thin layer chromatography; then followed by 30 %, 50%, 70%, and 90% ethanol to elute the macroporous resin, collect each part until...

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Abstract

The present invention relates to a Chinese medicine extract with action of reducing blood sugar. It is composed of polysaccharides, flavones and alkaloids obtained by separating and extracting mulberry leaf, mulberry twig and mulberry root bark. Their contents respectively are 24-27%, 53-61% and 15-20%. Said invention also provides the concrete steps of the above-mentioned separation and extraction process.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and discloses a method for extracting active ingredients from traditional Chinese medicines. More particularly, the invention relates to the extraction of components capable of treating diabetes and its complications from moraceae plants mulberry leaves, mulberry branches and Morus alba. These components can be applied to the treatment of diabetes and its complications. Background technique [0002] Mulberry leaves, mulberry branches and mulberry bark are the leaves, twigs and root bark of the mulberry tree, which are different parts of the same plant and are commonly used in traditional Chinese medicine. Mulberry leaves are the leaves of Moraceae Morus (Morus alba L.). The medicinal use of mulberry leaves was first recorded in "Shen Nong's Materia Medica". Mulberry leaves are bitter, sweet and cold in nature and taste, so the sweetness benefits the blood, and the coldness cools the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/605A61K31/352A61K31/395A61K31/70A61P3/10A61K127/00A61K129/00A61K135/00
Inventor 原爱红黄哲
Owner 原爱红
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