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Pharmaceutical composition for treating renal failure and its preparation and application

A composition and drug technology, applied in the direction of drug combination, drug formulation, drug delivery, etc., can solve the problem of ineffective drug effect

Active Publication Date: 2008-03-05
湖南达嘉维康医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after many years of clinical practice, the inventors of the present application found that the curative effect of the medicine made by mixing the above six formulas and extracting them with water or extracting Salvia miltiorrhiza with ethanol and other five-flavored medicines mixed and extracted with water was not obvious.

Method used

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  • Pharmaceutical composition for treating renal failure and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Example 1: Take 521g of rhubarb, crush it into a coarse powder, add 7 times the amount of 70% ethanol to reflux and extract 3 times, each time for 1 hour, let it cool, filter, and combine the filtrate; the remaining 417g of licorice with five flavors, 417g of salvia miltiorrhiza, and 417g of poria cocos , 209g Citrus aurantium, 209g decoction pieces of calcined oysters, decocted twice, first add 12 times the amount of water to decoct for 1.5 hours, second time add 8 times the amount of water to decoct for 1 hour, combine the decoction, filter, and filtrate Combined with the above alcohol extract, concentrated under reduced pressure to form a medicinal solution with a relative density of 1.08-1.10 (50-60°C), spray-dried to make 878g of dry cream powder, add appropriate amount of dextrin and micro-powdered silica gel, and mix well to prepare The granules are sieved and dried to make 1000g granules, which are divided into 16g bags.

Embodiment 2

[0075] Embodiment 2: Add appropriate amount of magnesium sulfate, dextrin and micropowder silica gel to the dry paste powder in embodiment 1, mix well, granulate, granulate, and compress into tablets.

Embodiment 3

[0076] Embodiment 3: the dry cream powder in embodiment 1, add appropriate amount of magnesium sulfate, dextrin and micropowder silica gel, mix, granulate, pack into capsule.

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Abstract

The invention relates to a pharmaceutical composition for treating kidney failure and process for preparation, wherein the prescription comprises (by weight percent) rhubarb horsetails 1-50%, licorice root 1-30%, radix salvia miltiorrhiza 1-20%, poria cocos wolf 1-20%, fruit of citron 0.1-20%, oyster 0.1-20%.

Description

1. Technical field: [0001] The invention relates to a medicine for treating kidney disease, in particular to a medicine composition for treating kidney failure and its preparation method and application. 2. Technical background: [0002] So far, there is still a lack of satisfactory treatment drugs and methods for chronic renal failure worldwide. Mainly rely on hemodialysis, peritoneal dialysis, kidney transplantation, and these treatment methods not only have many medical problems that are still difficult to solve, but also cost a lot of money. Once the patient develops renal failure, he needs to rely on dialysis to maintain his life. At present, there are quite a few units in China and Individuals cannot afford its huge cost. Especially in the vast rural areas, due to the limitation of medical equipment and technical conditions on the one hand, and the economic situation on the other hand, the vast majority of patients still rely on non-dialysis therapy. drugs for the tr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/752A61K36/53A61K36/076A61K35/56A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P13/12A61K35/618
Inventor 王毅清陈耀明
Owner 湖南达嘉维康医药有限公司