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Remedies for psychoneurosis

A drug and pharmacological technology, applied in the direction of nervous system diseases, drug combinations, medical formulas, etc., can solve problems such as unknown etiology, inability to establish treatment methods, and reduced quality of life

Inactive Publication Date: 2008-07-02
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] As mentioned above, RLS not only makes patients feel extremely unpleasant and reduces the quality of life, but also its exact etiology is unknown, and effective treatment methods have not yet been established. Therefore, it has become a major medical problem, and the development of more useful treatment methods is strongly demanded.

Method used

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  • Remedies for psychoneurosis
  • Remedies for psychoneurosis
  • Remedies for psychoneurosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] (-)-17-(cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamide ] Morphinan hydrochloride 1

[0064]

[0065] The solution containing 10 μg of the compound represented by the above formula was encapsulated into a gelatin-coated soft capsule to prepare an oral dose. The oral formulation was administered to 2 patients diagnosed with restless legs syndrome. 2 patients all privately complained that the lower limbs had an abnormal sensation of itching, which hindered sleep, and after taking the oral preparation, the abnormal sensation of the lower limbs disappeared in 2 hours and 4 hours in the other patient after taking the oral preparation. After at least 24 hours after taking the drug, the effect of disappearing the abnormal sensation continued in 2 patients, and they could fall asleep without causing sleep disturbance at night, so it is considered that the drug has a clear therapeutic effect on restless legs syndrome.

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Abstract

A therapeutic drug for psychoneurotic disorders, which is useful for therapies of psychoneurotic disorders, especially restless legs syndrome is disclosed. The therapeutic drug for psychoneurotic disorders according to the present invention comprises as an effective ingredient an opioid kappa receptor agonist compound (excluding pentazocine) such as (-)-17-(cyclopropylmethyl)-3,14beta-dihydroxy-4,5alpha-epoxy-6beta[N-methyl-trans-3-(3-furyl)acrylamide]morphinan hydrochloric acid salt.

Description

technical field [0001] The invention relates to drugs for treating mental and nervous diseases. The drug for treating mental and nervous diseases of the present invention can be used for the treatment of neurological diseases such as Restless legs syndrome (hereinafter often referred to as "RLS"). Background technique [0002] RLS is considered to be one of the neurological diseases of peripheral nerve disorders, and it is a disease that produces extremely unpleasant abnormal sensations such as strong itching in the lower limbs when resting or falling asleep. Occasionally, itching occurs in the upper extremities and trunk, but as the name of the disease is, it is characterized by strong abnormal sensations especially in the lower extremities. Once RLS occurs, the feet cannot be kept still. To relieve symptoms, the soles of the feet must be rubbed against each other, or the feet may be moved. Because severe cases cannot lie motionless on the bed, they have to get up and mov...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/485A61K31/40A61P25/00A61P25/04A61P25/20A61K31/00C07D241/04C07D265/28C07D279/12C07D295/13C07D295/135C07D409/12C07D489/08C07D491/10
CPCC07D279/12C07D265/28A61K31/00A61K31/485C07D409/12C07D489/08C07D491/10C07D241/04C07D295/135C07D295/13A61P25/00A61P25/02A61P25/04A61P25/20A61P43/00
Inventor 熊谷裕生内海润
Owner TORAY IND INC
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