Copolymer of imitating structure of cell membrane, prepartion method and application thereof

A technology of imitating cell outer layer membrane and membrane structure, applied in the field of cross-linkable acrylate terpolymer, can solve the problem of unstable tetrapolymer of amphiphilic polymer coating and the like

Inactive Publication Date: 2008-09-03
NORTHWEST UNIV(CN)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Still another object of the present invention is to provide the application of the above-mentioned amphiphilic terpolymer in the preparation of imitation cell outer membrane structure coating, in order to solve the instability of the usual amphiphilic polymer coating and the reaction of tetrapolymer formation. The problem of imitating the outer membrane structure of cells

Method used

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  • Copolymer of imitating structure of cell membrane, prepartion method and application thereof
  • Copolymer of imitating structure of cell membrane, prepartion method and application thereof
  • Copolymer of imitating structure of cell membrane, prepartion method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Get methacryloxypropyl trimethoxy silicon (MPS) monomer 0.58g, n-octadecyl methacrylate (SMA) monomer 3.3g, dissolve in 50ml isopropanol in a 250ml three-necked bottle : THF=3:1 (V / V) in anhydrous mixed solvent. 3.0 g of methacryloyloxyethoxyphosphorylcholine (MPC) and 0.020 g of initiator AIBN were respectively dissolved in 40 ml of the above mixed solvent. After 30 minutes of deoxygenation by nitrogen gas, 30% of the MPC solution and AIBN solution were added dropwise at 70°C at the same time, and the remaining part was added dropwise within 3 hours. Continue to reflux condensation at 70°C and stir for 10 hours. The product was precipitated with ether, rinsed, and washed with acetonitrile. use after drying 1 The content of each component was determined by H NMR spectrum. In the silane group (Si-C H 2 -) The chemical shift of the proton is ~0.7ppm; the chemical shift of the proton in the long chain alkyl group is 1.3ppm; the chemical shift of the proton in the pho...

Embodiment 2

[0037] Take 12g of methacryloxypropyltrimethoxysilane (MPS) monomer and 4.2g of n-butyl methacrylate (BMA) monomer and dissolve them in 80ml of absolute ethanol in a 250ml three-necked bottle. 3.0 g of methacryloyloxyethoxyphosphorylcholine (MPC) and 0.030 g of initiator AIBN were respectively dissolved in 40 ml of absolute ethanol. After passing through nitrogen to remove oxygen for 30 minutes, at 60° C., 30% of the MPC solution and AIBN solution were added dropwise at the same time, and the remaining part was added dropwise within 2 hours. It was then condensed under reflux at 65°C and stirred for 16 hours. The product was precipitated with ether, rinsed, washed with acetonitrile, and dried with 1 The molar content of each component of MPC, BMA and MPS measured by H nuclear magnetic resonance spectrum is 21%, 67% and 12%.

Embodiment 3

[0039] Get methacryloxypropyltrimethoxysilane (MPS) monomer 0.90g and dodecyl methacrylate (DMA) monomer 2.6g in the ethanol that dissolves in 80ml in the 250ml three-necked bottle: tetrahydrofuran=4 : 1 in an anhydrous mixed solvent. 3.5 g of methacryloyloxyethyltrimethylammonium chloride (DMC) and 0.030 g of initiator AIBN were respectively dissolved in 30 ml of a mixed solvent of ethanol:tetrahydrofuran=2:1. After passing nitrogen gas to remove oxygen for 30 minutes, 30% of the DMC and AIBN solution was added dropwise at 65° C., and the remaining part was added dropwise within 2 hours. It was then reflux condensed at 65°C and stirred for 24 hours. The product was precipitated with ether, rinsed, washed with acetonitrile, and dried with 1 The molar content of each component of DMC, DMA and MPS measured by H nuclear magnetic resonance spectrum is 60%, 29% and 11%.

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Abstract

This invention discloses a triblock copolymer with general chemical formula (I), wherein m and n are integers in 300-800; x is an integer in 10-200; m : n : x mol ratio is (20-70) : (20-70) : (9-30); R1, R2 and R3 are H or CH3; R4 is C4-24 alkyl; V is propyl trimethoxysilane or propyl triethoxysilane; W is C2-8 hydrophilic group. The triblock copolymer can be used to prepare coating layer imitating cell outer-membrane structure.

Description

technical field [0001] The invention relates to a cell-membrane-like copolymer, a preparation method thereof, and an application as a coating layer imitating the outer membrane structure of a material surface, in particular to a cross-linkable (meth)acrylic ester terpolymer, which belongs to macromolecule chemistry and physics , surface science and biomedical materials technology. Background technique [0002] Phosphorylcholine is a hydrophilic group of the outer membrane of biological cells. The modified material is coated with a hydrophilic-lipophilic amphiphilic polymer containing phosphorylcholine group, which can form a structure on the surface of the material that is opposite to the structure of the cell membrane. self-assembly layer. The surface of the modified material can be transformed into a cell-like membrane structure when in contact with water, which will be regarded as self by the cells, and excellent biocompatibility can be obtained. This kind of phosphoryl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/10C08F2/06C08J7/12C09D133/06B05D3/10
Inventor 宫永宽杨珊宫铭马佳妮张世平
Owner NORTHWEST UNIV(CN)
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