37 results about "Cell membrane structures" patented technology

The application discloses medical use of gelated cells loaded with sulfonated chitosan in treatment of atherosclerosis, and belongs to the technical field of biological medicine. The gelated cells loaded with sulfonated chitosan take macrophages as host cells, and intracellular cross-linking forms a photocrosslinking hydrogel network composed of methacrylated hyaluronic acid and sulfonated chitosan. The gelated cells completely retain cell membrane structure and membrane surface protein expression, lose the proliferation ability, and have excellent blood lipid selective adsorption capacity and foam cell lipid metabolism regulation capacity. In-vivo and in-vitro experiments prove that the gelated cells can significantly reduce blood lipid levels of atherosclerosis model animals, reduce aortic plaque area, and have good biological safety, thereby providing a new strategy and candidate drug for prevention and treatment of atherosclerosis, and having a good clinical application prospect.

The invention discloses a method for improving yield of anthocyanin extracted by an enzymic method, according to the method, phospholipase is added and used to act on a cell membrane structure, so that the extraction rate of the anthocyanin and the extraction rate of galactoside in the anthocyanin are obviously improved, and the extraction effect of the anthocyanin is greatly improved through a three-stage enzymolysis system. The total enzymolysis extraction time is within 4 h, and compared with 6-7 h of a traditional enzymatic extraction process, the production period is greatly shortened.

The invention relates to a quinoxaline derivative containing trimethyl and n-propyl as well as a preparation method and application of the quinoxaline derivative, and the derivative is 1, 6, 7-trimethyl-3-propyl quinoxaline-2 (1H)-ketone and is particularly suitable for inhibiting fusarium oxysporum. The derivative is prepared by an organic synthesis method which comprises the step of carrying out cyclization reaction on N-protected o-phenylenediamine and a carbonyl compound in the presence of trifluoroacetic acid. Experiments show that the compound has a remarkable antibacterial effect on fusarium oxysporum, and the minimum inhibitory concentration is 0.50 mg / mL. The derivatives can destroy the cell membrane structure of fusarium oxysporum and cause leakage of RNA, protein and reducing sugar in cells, so that the growth of thalli is inhibited. The invention provides a theoretical basis and an experimental basis for developing a novel efficient and low-toxicity bacteriostatic agent.

The invention discloses a method for killing bovine herpesvirus by sodium chloride aerosol. The method comprises the following steps: (1) preparing sodium chloride aerosol of which the average particle size is 800nm and the particle size distribution is between 500nm and 8mu m, in the specific preparation process, respectively introducing a saturated sodium chloride aqueous solution and absolute ethyl alcohol into dry airflow of a spray dryer according to a volume ratio of 1: 1, and drying by the spray dryer to prepare the sodium chloride aerosol; and (2) the prepared sodium chloride aerosol is used as a bovine herpes virus killing agent to kill bovine herpes viruses, and in the virus killing process, the dosage is 10-60 mg, and the killing time is 10-30 s. The sodium chloride aerosol has the advantages that the sodium chloride aerosol has special antivirus efficacy in a specific dosage and time range, a high-concentration sodium chloride solution can dehydrate bacterial cells and destroy cell membrane structures of the bacterial cells through osmotic pressure difference to cause growth inhibition or death of bacteria, and especially 100% of bovine herpes viruses (BHV-1) can be killed in a very short time with a small dosage of sodium chloride aerosol.

The invention relates to the technical field of antibacterial composition preparation, in particular to a gynecological antibacterial composition and a preparation method thereof, and the gynecological antibacterial composition comprises the following raw materials: modified radix sophorae flavescentis, angelica sinensis, modified cortex phellodendri, radix paeoniae rubra, ligusticum wallichii, bombyx batryticatus, salvia miltiorrhiza, safflower carthamus, fructus cnidii, gallnut, calamine, pomegranate rind, catechu, rhizoma atractylodis, dragon's blood, fructus kochiae, borneol, alum, dried alum, purpurea sal ammoniac, magnesium stearate and starch. According to the invention, after the modified radix sophorae flavescentis is subjected to ethanol ultrasonic extraction, purification and micronization treatment, the dissolution rate and purity of effective components such as sophocarpidine are improved, the cell membrane structure of gram-negative bacteria such as escherichia coli can be quickly destroyed, and efficient bacteriostasis is realized; the modified cortex phellodendri is subjected to alkali dissolution extraction, acid precipitation purification and refined drying, berberine hydrochloride is efficiently enriched, the purity is improved, and the berberine hydrochloride can kill fungi such as candida albicans more accurately and strongly; and through high-temperature calcination and acetic acid activation, the calamine and the catechu are tightly combined at a microscopic level, so that the inherent convergence, granulation promoting and antibacterial effects of the calamine and the catechu are enhanced.

The invention discloses an oenothera biennis lodging-resistant quality-improving yield-increasing functional fertilizer and preparation and use methods thereof, and belongs to the technical field of agricultural cultivation, the fertilizer comprises an active component A and an active component B. The active component A comprises one or more of methyl jasmonate, boric acid, monopotassium phosphate, gibberellin, water-soluble silicon, MgSO4, calcium chloride and melatonin, and the active component B comprises one or more of methyl jasmonate, boric acid, monopotassium phosphate, gibberellin, water-soluble silicon, MgSO4, calcium chloride and melatonin. The active ingredient B is choline chloride; the content of the active component A accounts for 0.5-15.5% of the total weight of the fertilizer, the biological yield, the economic yield and the oil content of the evening primrose are inspected, and when the active component A is single-component methyl jasmonate, the effect is good; when the active component A is composed of multiple components including jasmonic acid methyl ester, the substances provide nutrient elements for the cell wall of the evening primrose, stabilize the cell membrane structure and play a synergistic promotion role in secondary cell wall lignification, so that the lodging-resistant and disease-resistant characteristics of the evening primrose are improved.

The invention discloses a non-destructive culture medium replacement device and method for microalgae, and relates to the technical field of microbiological treatment. Comprising a frame body, a water storage assembly used for storing pure water and calcium-free seawater is arranged above the frame body, a replacement box is arranged in the middle of the frame body and used for containing a dialysis bag containing algae liquid, and the pure water or the calcium-free seawater can flow in and out at the same flow speed through a pipeline and a flow control valve; a collecting assembly used for receiving water discharged from the replacement box is arranged below the frame body. And two groups of symmetrically arranged transverse frames are fixedly mounted in the middle of the frame body. According to the device, a traditional centrifugal method is replaced by physical isolation and micro-vibration auxiliary replacement of the dialysis bag, a knocking assembly driven by a cam is matched with a spring buffer structure, the movement of liquid in the bag is accelerated, meanwhile, mechanical impact force is controlled within a certain amplitude range, it is ensured that the structure of a microalgae cell membrane is complete, and the survival rate is greatly increased; and a high-activity sample is provided for subsequent calcium signal research.

The utility model provides a kind of mixing device for freeze-drying probiotic production line, it is related to probiotic freeze-drying production device technical field, including mixing barrel, stirring device and distributor, the mixing barrel top portion is provided with top cover, mixing barrel bottom is equipped with discharge gate, stirring device is evenly spaced transversely installed in mixing barrel around mixing barrel axis line, the top cover of distributor is coaxial with the mixing barrel and is installed, the distributor bottom is provided with several groups of material distribution hole corresponding with the direction of stirring device in mixing barrel, the application can solve the problem that traditional liquid needs to be combined with the mode that single-point feeding and high-speed paddle type mechanical stirring are combined to form local concentration too high, mixing is not uniform and high shear force destroys bacterial cell membrane structure, causes the problem of active bacteria survival rate decline.

The invention relates to a breast milk cold sterilization and freeze-drying method for full-closed treatment and application thereof, and is characterized in that the method comprises the following steps: injecting breast milk into a collection bag, carrying out vacuum sealing treatment, carrying out sterilization treatment by adopting cold sterilization, and carrying out freeze-drying to obtain freeze-dried breast milk; the cold sterilization comprises the steps of putting the collection bag into a closed pressure treatment cabin, and carrying out pressure treatment twice. According to the method disclosed by the invention, cold sterilization is adopted to uniformly transfer pressure to microbial cells in breast milk by utilizing the incompressible characteristic of a food-grade hydraulic medium on the premise of not depending on thermal action and avoiding damage of heat to nutritional ingredients, and efficient sterilization is realized by destroying cell membrane structures, enzyme active sites and genetic materials of microorganisms.

This invention discloses an umbilical cord mesenchymal stem cell membrane for treating hair loss, its preparation method, and its application, belonging to the field of biomedical technology. The preparation method of the umbilical cord mesenchymal stem cell membrane includes the following steps: obtaining human umbilical cord mesenchymal stem cells, digesting, centrifuging, washing, and resuspending them to obtain a resuspended cell solution; subjecting the resuspended cell solution to repeated freeze-thaw cycles to break the cells, obtaining a cell lysate; and subjecting the cell lysate to differential centrifugation to obtain the umbilical cord mesenchymal stem cell membrane. This umbilical cord mesenchymal stem cell membrane retains the natural cell membrane structure and functional proteins, has a negatively charged surface, and exhibits good dispersibility and stability. It can improve the survival rate of dermal papilla cells without introducing live cells and effectively regulate the skin microecology and metabolite balance, demonstrating high safety, good biocompatibility, and excellent hair growth promotion effects.

The application discloses a selenium-based metal polyphenol-based nanoparticle and a preparation method and application thereof, and belongs to the technical field of biological materials. The selenium-based metal polyphenol-based nanoparticle is composed of a selenium-based catalytic center, metal ions and non-enzyme molecular ligands, and a stable nano structure is constructed through coordination of the metal ions and polyphenols. The application also discloses a preparation method of the nano enzyme. The nano enzyme can efficiently remove lipid peroxides and lipid hydroperoxides under the participation of glutathione, and has very low non-specific catalytic activity to the POD pathway. The nanoparticle has good biocompatibility, can effectively reduce lipid peroxidation damage induced by oxidative stress, and can maintain the stability of the structure and function of the cell membrane, and can be used for prevention and treatment of oxidative stress-related diseases, and is especially suitable for diseases with lipid peroxidation and ferroptosis as the main pathological mechanism.

This invention relates to the field of agricultural biotechnology, and in particular to a stress-resistant, antifreeze, and preservative biofilm formulation and its preparation method. The stress-resistant, antifreeze, and preservative biofilm formulation is composed of the following raw materials in parts by weight: 13-28 parts film-forming matrix, 5.5-11.5 parts antifreeze active component, 2.51-6.05 parts stress-resistant active component, 7-14 parts crosslinking and plasticizer, 0.1-0.5 parts natural antibacterial agent, and 55-75 parts deionized water. This invention innovatively achieves a four-fold synergy of physical barrier, active stress resistance, efficient antifreeze, and natural antibacterial properties. The film-forming matrix forms a dense and breathable physical barrier, inhibiting moisture loss; the stress-resistant components construct an active stress-resistant system, enhancing the stress resistance of agricultural products; the antifreeze components achieve efficient antifreeze by inhibiting ice crystal formation and stabilizing cell membrane structure; and the natural antibacterial agent specifically inhibits postharvest pathogens such as Penicillium and Botrytis. The four components work synergistically to comprehensively solve multiple problems during the storage of agricultural products.

The invention relates to the technical field of functional boards, in particular to an antibacterial food-grade board and a preparation method thereof.The antibacterial food-grade board is prepared from, by weight, 100 parts of polypropylene resin, 5-15 parts of a composite additive, 8-12 parts of a functional additive, 0.3-0.8 part of an antioxidant 1010 and 0.5-1.5 parts of calcium stearate. The functional additive is compounded with sulfamic acid and a reaction solution containing epsilon-polylysine, epsilon-polylysine can destroy the completeness of bacterial cell membranes and exerts a long-acting antibacterial effect with other substances in the additive through chemical bonding, and the functional additive is compounded with a fructus cnidii extract by utilizing active ingredients of Chinese prickly ash seeds, so that the antibacterial effect of the functional additive is improved. The antibacterial effect is enhanced by destroying a microbial cell membrane structure, and the antibacterial property and food safety of the plate are effectively improved.

The application belongs to the technical field of microorganisms, and discloses application of shikimic acid in preparation of antibacterial preparations for inhibiting staphyloxin synthesis. It is found that shikimic acid can inhibit synthesis of staphyloxin in methicillin-resistant Staphylococcus aureus (MRSA), reduce tolerance of the bacteria to oxidative stress, induce accumulation of intracellular active oxygen, and damage cell membrane structure and function, including reducing cell membrane order, inducing membrane depolarization, increasing membrane permeability, and leading to ATP leakage and energy metabolism disorder. A new strategy and preparation direction are provided for clinical treatment of multi-drug resistant Staphylococcus aureus infection, and the application has important theoretical value and application prospect.

The invention discloses construction and application of an engineering strain capable of normally growing at 35 DEG C and realizing high yield of xanthan gum. The method comprises the following steps: by taking xanthomonas campestris XC1 as an initial strain, carrying out ARTP mutagenesis treatment, and screening a mutant strain which can normally grow under the condition of 35 DEG C; the mutant strain is subjected to multiple rounds of superposition transformation, and multiple physiological restrictions under high temperature stress are systematically broken by sequentially strengthening a protein folding system (grpE-ATGA-dnaK), activating outer membrane stress regulation (rpoE), constructing an anti-oxidation barrier (katB) and strengthening a cell membrane structure (polCDE); the finally obtained engineering strain shows the performance far better than that of an initial strain under the condition of 35 DEG C; the biomass of the strain is increased by 207.7% compared with that of an initial strain XC1, and the yield of xanthan gum is increased by 75.5% and reaches 25.8 g / L, which is consistent with the yield of xanthan gum under the fermentation condition of 28 DEG C.

The present application belongs to the field of biotechnology, and particularly relates to a kind of production alpha-ketoglutaric acid recombinant escherichia coli engineering strain and its construction method and application.The present application engineering strain A09 can realize high-efficiency catalysis to high-concentration L-glutamic acid sodium without adding any membrane breaker such as Triton X-100.Under the condition of high-intensity catalysis for 6 hours, the cell membrane structure of the bacterial cell is kept intact without obvious damage.This characteristic completely eliminates the problems such as cell toxicity, product purification complexity, cost increase and process safety reduction caused by the use of surfactant in traditional methods, realizes the perfect unity of "cell integrity" and "high catalytic efficiency", and provides an unprecedented technical solution for the large-scale, industrialized and low-cost production of alpha-ketoglutaric acid.

The invention belongs to the technical field of biological medicine and cell therapy, and particularly relates to a preparation method of a human-derived nasal mucosa mesenchymal stem cell medicine for treating sepsis, which comprises the following steps: cell separation: taking adult nasal mucosa tissues, cutting into pieces, digesting with 0.25% pancreatin, and terminating digestion with a DF12 culture medium containing 20% serum; primary culture: after the tissue adheres to the wall for one week by using the first-step culture medium, replacing a DF12 culture medium containing 10% of serum, and after the cells climb out of the tissue, centrifugally collecting the cells for primary culture; 3, primary culture: identifying a fourth generation of cell surface marker in primary culture by flow cytometry, the invention reveals the deep mechanism of function enhancement of HuNMSCs by inhibiting cell autophagy, maintaining the integrity of a cell membrane structure and improving the survival rate of a sepsis model through molecular means such as lipid metabonomics and the like for the first time, and the deep mechanism of function enhancement of the HuNMSCs is illustrated by using the HuNMSCs to inhibit cell autophagy, maintain the integrity of a cell membrane structure and improve the survival rate of the sepsis model. The possibility of treating sepsis by HuNMSCs is clarified, a brand new cell treatment strategy is provided for sepsis, and a foundation is laid for subsequent clinical application.

The invention discloses an avian influenza virus poisoning agent, virus killing application and a virus killing method. And directly using the sodium chloride aerosol with the average particle size of 800nm and the particle size distribution of 500nm-8mu m as the avian influenza virus poisoning agent. The sodium chloride aerosol has the advantages that the sodium chloride aerosol with the average particle size of 800nm and the particle size distribution of 100nm-8mu m is prepared by combining an anti-solvent, a spray drying method and specific process parameters and is directly used as the avian influenza virus poisoning agent, the sodium chloride aerosol has the virus killing effect in a specific dosage and time range, bacterial cells can be dehydrated by a high-concentration sodium chloride solution through osmotic pressure difference, and the concentration of the sodium chloride solution in the avian influenza virus poisoning agent is reduced. The sodium chloride aerosol is used for killing the H9N2 subtype avian influenza virus, the cell membrane structure of the H9N2 subtype avian influenza virus is damaged, the growth inhibition or death of the bacteria is caused, especially, 100% killing of the H9N2 subtype avian influenza virus can be achieved with a small amount of sodium chloride aerosol and a short time, and the effect is very

The invention provides a seed soaking agent for enhancing stress-resistant growth of tomato seedlings in a high-temperature environment as well as a preparation method and application of the seed soaking agent, and belongs to the technical field of seed soaking agents. The seed soaking agent comprises boric acid, jasmonic acid, gamma-aminobutyric acid, cane sugar, proline and water. The boron element is an important micronutrient element for plant growth and development, and participates in cell wall formation, glycometabolism and membrane structure stability maintenance; jasmonic acid is a plant hormone and participates in regulation and control of defense reaction of plants to adversity and activation of an anti-oxidation system; the gamma-aminobutyric acid as a non-protein amino acid can be quickly accumulated in the plant body to effectively maintain ion balance, remove active oxygen and stabilize the cell membrane structure, so that the heat resistance of the plant is enhanced. The three components are compounded, and cane sugar and proline are supplemented to construct the compound seed soaking agent, so that the stress-resistant growth performance of tomato seedlings in a high-temperature environment can be enhanced.

This invention relates to the field of fertilizer technology and discloses a biomass fertilizer for improving the soil environment and its preparation method. The invention uses lignin graft copolymer and modified sodium alginate as raw materials, and prepares a composite hydrogel using the calcium ion in-situ gelation method. Biochar, urea, and potassium dihydrogen phosphate are then added to the hydrogel to obtain a biomass fertilizer for improving the soil environment. The pyrrole groups in the lignin graft copolymer and the nitrogen atoms in the Mannich base structure act as hydrogen bond acceptors, enhancing the hydrogen bonding with the hydrogel molecular chains and improving the water retention capacity of the fertilizer. The rigid structure of lignin itself also plays a role in the gel network, reducing the collapse of the cross-linked network, thereby forming a richer three-dimensional porous structure and enhancing the water retention capacity of the fertilizer. Quaternary ammonium salt groups can disrupt the bacterial cell membrane structure, leading to the extravasation of bacterial substances and enhancing the antibacterial effect of the fertilizer. Thiourea groups can bind to enzymes within bacterial cells, exerting an antibacterial effect.

The invention relates to the technical field of pet food, in particular to natural antibacterial wet food for pets and a preparation method thereof.The natural antibacterial wet food for pets comprises fermented pea protein, fresh meat / fish, fermented hibiscus cannabinus seed protein and the like, and antibacterial and fresh-keeping effects are achieved through lactic acid bacteria fermentation products and microcapsule herbal compounds; the formula also contains organic acid, a natural chelating agent, vitamins, cranberry extract and the like, the total water content reaches 75-78%, lactobacillus plantarum produced by pea protein under the action of lactobacillus plantarum can destroy cell membrane structures of various gram-positive bacteria, and pediococcus produced by pediococcus has a specific inhibition effect on pathogenic bacteria such as listeria monocytogenes. Through the synergistic effect of the two types of bacteriocin, the antibacterial spectrum is expanded, and respective antibacterial blind areas are filled up.

The invention relates to the technical field of daily chemicals, in particular to a composition for reducing bacterial pollution and promoting wound healing after medical treatment and application of the composition. The composition is prepared from the following components: polyquaternium-51, a silk extract, beta-glucan and bio-saccharide gum-1. The composition disclosed by the invention can form a breathable and antibacterial film on the skin; the polyquaternium-51 firstly forms a stable basic cation layer similar to a cell membrane structure on the surface of the skin; the film can prevent water loss and inhibit static electricity and dust adsorption. The silk extract forms a layer of uniform and breathable three-dimensional fiber network with slight negative charges on the substrate. The network enhances the stability and elasticity of the whole membrane, so that the membrane does not close the skin. The bio-saccharide gum-1 and the beta-glucan are used as high-molecular polysaccharides, the viscosity characteristic of the bio-saccharide gum-1 and the beta-glucan contributes to consolidating and enhancing the stability and the water holding capacity of the composite film, and the film with good breathability, moisture retention and bacteria resistance is cooperatively formed.

This invention relates to a method for the simultaneous removal of antibiotic-resistant bacteria and resistance genes using a solar-driven interfacial heat-Fenton oxidation-like process. The method involves placing a photothermal film loaded with carbon black composite photothermal material in a photothermal sterilization reactor, introducing antibiotic-resistant wastewater, adding H2O2, turning on a xenon lamp to preheat the photothermal film, sealing the reactor, and allowing the wastewater to pass through the photothermal film under gravity. This invention utilizes a photothermal conversion material to absorb light radiation and convert it into thermal radiation, treating antibiotic-resistant bacteria through the high-temperature interfacial heat effect generated on the photothermal film. High-temperature interfacial heat causes localized heating of the bacterial cell membrane structure, leading to a certain degree of breakage of fatty acid chains in the bacterial membrane lipid bilayer. This increases cell membrane permeability, and the resulting physical damage damages the bacterial outer membrane structure, further increasing membrane permeability and thus disrupting membrane integrity.

The invention discloses a composition acting on an ovary somatic cell membrane structure and application of the composition. The composition acting on the ovary somatic cell membrane structure comprises the following components in parts by weight: 12-18 parts of a clove extract, 4-8 parts of a sophora flower bud extract, 8-12 parts of Chinese yam protein polypeptide, 4-8 parts of a cranberry extract and 8-12 parts of a citrus extract. The composition can act on an ovary somatic cell membrane structure to improve the mitochondrial function of oocytes, increase the number of the oocytes and reduce the fragment rate of the oocytes, so that the ovary function of elderly women is improved, and the purposes of improving the fertility and delaying senescence are achieved.

This invention provides a wall-mounted disinfection device, comprising a housing, an air inlet assembly with a primary filter at the lower end of the housing, and an air outlet assembly at the upper end of the housing; a wall-mounting connector located on the back of the housing; a disinfection assembly positioned between the air inlet and outlet assemblies, comprising at least two layers of flexible disinfection mesh made of a flexible, high-temperature resistant material, with nano-disinfecting materials loaded on its surface; a monitoring module positioned between the air inlet and outlet assemblies; and a control module connected to a display panel; and a power supply module including a charging circuit board and an external power interface. The beneficial effect is that by using a flexible disinfection mesh loaded with nano-disinfecting materials as the core disinfection component, the nanomaterials can effectively destroy the cell membrane structure of bacteria and viruses. Combined with an optional ultraviolet-assisted disinfection lamp, synergistic disinfection is achieved, achieving a sterilization rate of up to 99%, and exhibiting excellent purification effects on harmful pollutants such as PM2.5 and formaldehyde in the air.

This invention relates to a multi-effect skincare essence for improving skin function and its preparation method. The invention supplements essential lipids and phospholipid precursors for the skin by adding linoleic acid and ethanolamine, strengthening the stratum corneum barrier and cell membrane structure integrity. It also adds serum albumin to address the poor water solubility and easy oxidation of linoleic acid and ethanolamine, improving the stability and skin affinity of the active ingredients. Simultaneously, it adds stable inorganic salts of essential trace elements such as selenium, silicon, tin, vanadium, manganese, and molybdenum to enhance the skin's anti-aging, repair, and firming abilities. Furthermore, it adds transferrin, which, on the one hand, blocks iron-mediated Fenton reactions and free radical generation, reducing photoaging and oxidative stress damage; on the other hand, transferrin prevents oxidative inactivation of linoleic acid, vitamins, selenium, tin, and other components under iron ion catalysis, reducing oxidative loss and protecting the formula's activity. Thus, it synergistically achieves effects such as barrier repair, anti-inflammatory soothing, anti-aging and firming, and brightening of skin tone.

This invention relates to the field of traditional Chinese medicine preparations, and discloses a topical preparation of black alum for treating malaria and rapidly regulating anemia. It is composed of black alum, cinnabar, artemisia annua extract, dichroa febrifuga extract, angelica sinensis extract, astragalus membranaceus extract, and pharmaceutical excipients. Based on black alum and cinnabar, this invention incorporates artemisia annua extract and dichroa febrifuga extract. Black alum exerts its insecticidal effect by disrupting the cell membrane structure of Plasmodium; cinnabar inhibits nucleic acid synthesis in Plasmodium; artemisinin interferes with mitochondrial function in Plasmodium; and dichroa febrifuga alkaloids inhibit protein synthesis in Plasmodium. The preparation is made into a nasal powder, administered through nasal inhalation. It is directly absorbed into the bloodstream through the rich capillaries of the nasal mucosa, rapidly replenishing the body's iron and promoting hemoglobin synthesis. The added angelica sinensis and astragalus membranaceus extracts have blood-tonifying and qi-boosting effects, enhancing the body's hematopoietic function, improving microcirculation, and accelerating the improvement of anemia symptoms.

The application discloses an antibacterial dendritic polyester macromolecule, a preparation method and application thereof, and belongs to the biomedical field. The amino is grafted on the branch of the dendritic macromolecule to prepare an ideal antibacterial polyester macromolecule; the protonation of the amino contains a positive charge structure, which can effectively penetrate into the bacterial cell membrane structure to cause the antibacterial mechanism of the biological macromolecule modification, so that the grafting abundance of the macromolecule amino is improved, and the antibacterial effect of the polyester macromolecule is enhanced.

The invention relates to the technical field of adhesives, in particular to an acrylic acid adhesive with excellent aging resistance and weather resistance and a preparation method of the acrylic acid adhesive. According to the acrylic copolymer with the phosphorylcholine group, a phosphorylcholine monomer similar to a cell membrane structure is introduced to participate in copolymerization, and the acrylic copolymer specifically comprises acrylic polymerization, an antistatic agent, an antioxidant, a catalyst, an oligomer silicon additive, a curing agent, an adhesive solvent and a catalyst complexing agent; the glue prepared by the invention has excellent aging resistance and high weather resistance, and also can keep higher adhesive force to display screens made of different materials so as to adapt to high requirements of rapidly developed electronic products on the acrylic optical glue.

The invention belongs to the technical field of biology, and particularly relates to a recombinant escherichia coli engineering strain for producing alpha-ketoglutaric acid as well as a construction method and application of the recombinant escherichia coli engineering strain. The engineering strain A09 disclosed by the invention can realize efficient catalysis of high-concentration L-sodium glutamate under the condition that any membrane rupture agent such as Triton X-100 and the like is not added at all. And in a high-strength catalysis process as long as 6 hours, the cell membrane structure of the thallus is kept complete and is not obviously damaged. According to the characteristic, a series of problems of cytotoxicity, complex product purification, cost increase, process safety reduction and the like caused by use of a surfactant in a traditional method are thoroughly abandoned, and perfect unification of cell integrity and high catalytic efficiency is realized; and an unprecedented technical solution is provided for large-scale, industrial and low-cost production of alpha-ketoglutaric acid.