Application of danshinolic acid B in inhibition of islet amyloid polypeptide aggregation and treatment of diabetes

A technology of amyloid polypeptide and salvianolic acid, applied in the field of medicine, can solve problems such as aggravation of diabetes and β-cell function damage
CN102961372AInactive Publication Date: 2013-03-13HUAZHONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUAZHONG UNIV OF SCI & TECH
Publication Date
2013-03-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of medicines. Danshinolic acid B has functions of inhibition of islet amyloid polypeptide aggregation and treatment of diabetes. The in-vivo islet amyloid polypeptide aggregation can destroy a beta-cell membrane structure and a normal form function of mitochondria to cause beta-cell apoptosis and damage a beta-cell function, thereby being taken as an important nosogenesis of type-2 diabetes. By danshinolic acid B, the aggregation of the islet amyloid polypeptide can be inhibited, and the process of damaging the beta-cell membrane structure and the normal form function of mitochondria during aggregation is changed over to protect the beta-cells, so that danshinolic acid B can be used for preventing and treating the diabetes.
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Description

technical field

[0001] The invention belongs to the field of medicine and relates to a medicine for treating diabetes. Background technique

[0002] Diabetes is an endocrine disease caused by the body's own nutritional and metabolic disorders. Its basic biochemical characteristics are persistent high blood sugar. It has become the fifth leading cause of death in the world. disease.

[0003] Diabetes is divided into type 1 and type 2, and the number of type 2 diabetes (T2DM) accounts for more than 90% of the total number of diabetic patients. The basic feature of type 2 diabetes is: on the basis of insulin resistance, the function of β cells is damaged. The pathogenesis of type 2 diabetes has not yet been elucidated. Islet amyloid polypeptide (Islet amyloidpolypeptide, IAPP) is co-secreted by pancreatic β cells together with insulin, and consists of 37 amino acid polypeptides. Under physiological conditions, IAPP can cooperate with blood sugar regulating hormones such as i...

Claims

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