Composite biological material and preparing method

A composite biomaterial, polylactic acid technology, applied in the field of carbon fiber reinforced hydroxyapatite/polylactic acid composite biomaterial and its preparation, can solve problems such as unsatisfactory mechanical strength and inability to meet the requirements for the fixation strength of large bone segments. Achieve the effect of simple preparation method

Inactive Publication Date: 2008-10-22
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical strength of HA / PLA composites is not ideal, especially it cannot meet the requirements of the fixation strength of large bone segments.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Components of the composite biological material and their weight percent content: polylactic acid (PLA) 90%, hydroxyapatite (HA) 9.0%, carbon fiber (CF) 1.0%.

[0016] Preparation:

[0017] Take PLA, HA and CF in proportion, first mix PLA and HA, add solvent chloroform, and stir thoroughly to obtain HA / PLA suspension, then disperse CF evenly in HA / PLA suspension under stirring, and volatilize the solvent at room temperature to obtain Impregnated tape, put the impregnated tape into the mold, put the mold with the prepreg tape into the hot press, heat press at 160°C and 10MPa for 20 minutes, and open the mold to take out the sample.

[0018] Test the mechanical properties and biodegradability of composite materials:

[0019] The prepared material is placed in simulated body fluid (PBS liquid of pH7.4, formula: NaCl 137mmol / L, KCl 2.7mmol / L, NaCl 2 HPO 4 4.3mmol / L, KH 2 PO 4 1.4mmol / L), soaked for 3 months, took out, washed and dried, and measured the pH value chang...

Embodiment 2

[0024] Components of the composite biological material and their weight percentage contents: polylactic acid (PLA) 85%, hydroxyapatite (HA) 13.8%, carbon fiber (CF) 1.2%.

[0025] Preparation:

[0026] Take PLA, HA and CF in proportion, first mix PLA and HA, add solvent chloroform, and stir thoroughly to obtain HA / PLA suspension, then disperse CF evenly in HA / PLA suspension under stirring, and volatilize the solvent at room temperature to obtain Impregnated tape, put the impregnated tape into the mold, put the mold with the prepreg tape into the hot press, heat press at 170°C and 12MPa for 25 minutes, and open the mold to take out the sample.

[0027] Test the mechanical properties and biodegradability of composite materials:

[0028] The prepared material was placed in simulated body fluid (PBS solution with pH 7.4, the formula is the same as in Implementation 1), soaked for 3 months, taken out, washed and dried, and measured the pH value change of the soaked material soluti...

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PUM

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Abstract

The present invention discloses a composite biological material. Said composite biological material is made up by using 80-90 wt% of polylactic acid, 8.8-19.2 wt% of hydroxyl apatite and 0.8-1.2 wt% of carbon fibre through a certain preparation process. Said invention also provides the concrete steps of said preparation process.

Description

technical field [0001] The invention relates to a composite biological material and a preparation method thereof, in particular to a carbon fiber reinforced hydroxyapatite / polylactic acid composite biological material and a preparation method thereof Background technique [0002] Polylactic acid (PLA) is an absorbable polymer. It has the characteristics of non-toxic, non-irritating and good biocompatibility. It can be degraded into lactic acid in the human body, and it is naturally metabolized without residue. Therefore, it is widely used as a fracture repair material, Surgical sutures, controlled release drugs, etc. Although PLA has many excellent properties, due to the low mechanical strength of the PLA fracture internal fixation device, it cannot meet the fixation requirements of many functional bones, so it must be combined with other materials to achieve the purpose of reinforcement. Carbon fiber (CF) is the preferred PLA reinforcement material because of its high stre...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46
Inventor 沈烈彭懋乔飞张稚燕郑强
Owner ZHEJIANG UNIV
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