Method and system for testing heterodyne phase of resonance biochemical multichannel of surface plasma

A surface plasmon and phase detection technology, applied in the field of biotechnology detection, can solve problems such as difficulty in meeting requirements, and achieve the effects of short return optical path, high sensitivity, no labeling and real-time detection

Inactive Publication Date: 2009-01-14
TSINGHUA UNIV
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Problems solved by technology

However, in actual detection, small molecule detection (such as small molecule drug targets in drugs) and analytes with low abundance (such as early cancer-related antibodies) are often encountered, which requires high sensitivity, but the above 3 methods are difficult to meet the requirements

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  • Method and system for testing heterodyne phase of resonance biochemical multichannel of surface plasma
  • Method and system for testing heterodyne phase of resonance biochemical multichannel of surface plasma
  • Method and system for testing heterodyne phase of resonance biochemical multichannel of surface plasma

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[0034] The surface plasmon resonance biochemical multi-channel heterodyne phase detection method and its system protected by the present invention will be described below in conjunction with the accompanying drawings.

[0035] The present invention is made up of biosensing unit 1, incident arm, reflection arm and signal processing unit 29 four parts, as Figure 4 shown. Wherein, the biosensing unit 1 is a surface plasmon resonance imaging biosensor, comprising a right angle, isosceles triangle or trapezoidal prism 30, a refractive index oil layer 31 and a multi-channel sensor chip 32 placed on the bottom surface of the right angle, isosceles or trapezoidal prism 30 And the sample pool 17 placed under the multi-channel sensing chip 32; the incident arm is located on one side of the biosensing unit, and is made up of a chirped optical fiber heterodyne interferometer 64, a polarizer 24 and the first lens 25; the The chirp optical fiber heterodyne interferometer described above i...

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Abstract

This invention relates to surface plasma resonance multi-channel outside phase test method and its system in biological test field, which is based on surface plasma resonance principle and adopts outside phase difference test method, wherein, the system is composed of incidence arm, biological sensor unit, reflection arm and signal process unit; the incidence arm comprises multi-channel linear modulation fiber intervene, bias slice and first lens and reflection arm. The invention is characterized by the following: light reflected by multiple channel chips is projected to reflection lens along original path through second sensor chip at same one test point.

Description

technical field [0001] The invention belongs to the field of biotechnology detection, and particularly relates to high-precision, multi-channel, real-time sensing protein-protein, protein-DNA, DNA-DNA, protein-effector, antigen-antibody, ligand-receptor, drug -A detection method for the interaction of biomolecules such as targets and a protein chip detection system thereof. Background technique [0002] The human life process is a process of interactions between biomolecules, especially protein-protein interactions. The occurrence and development of diseases are all related to the interaction between proteins. The treatment process of a disease is also a protein-drug interaction process. Therefore, the interaction between protein-protein and protein and other biomolecules has become one of the main research contents of proteomics. [0003] Using the sensing principle of surface plasmon resonance imaging to detect biomolecular interactions has the advantages of label-free,...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/55G01N33/50G01N21/552
Inventor 章恩耀余兴龙耿俊清
Owner TSINGHUA UNIV
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