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Methods for repairing and regenerating human dura mater

A dura mater and biological matrix technology, applied in medical science, prosthesis, etc., can solve the problems of not being able to provide reabsorbable replacement dura mater, spreading microorganisms, viruses and prions, etc.

Inactive Publication Date: 2009-03-25
BAXTER INT INC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] Known dural substitute materials, and related methods of using them, do not provide a liquid-impermeable, resorbable replacement dura that avoids encapsulation, dural scarring, or adhesion in the on brain tissue and also has a low risk of spreading microorganisms, viruses, and prions that may cause spongiform encephalitis or other diseases

Method used

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  • Methods for repairing and regenerating human dura mater
  • Methods for repairing and regenerating human dura mater
  • Methods for repairing and regenerating human dura mater

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] This example provides the results of an experiment conducted with sheep to evaluate the suitability of equine collagen flakes as a dura mater substitute for repairing dura mater tissue and as a biological matrix for dura mater regeneration.

[0126] Experiments were performed in order to evaluate the properties of equine collagen flakes as a skull dura mater substitute, as studied in a sheep model. The equine collagen flakes consisted of native equine collagen fibrils (5.6 mg / cm 2 ) and does not include cellular components.

[0127] The reference product used was preserved human cadaver dura mater ( Dura). Both products were attached in place using only fibrin glue (Tissucol Duo S Immuno, Baxter AG, Vienna, Austria).

[0128] The following items were studied:

[0129] Visual inspection of the integration of the two grafts;

[0130] Reactions of adjacent tissue structures (inflammation, adhesions, fibrosis, necrosis); and

[0131] Histological assessment of inte...

Embodiment 2

[0257] Example 2 - Swellability of Equine Collagen Flakes

[0258] Studies concerning the swelling capacity of the equine collagen flakes were carried out as follows:

[0259] 1) First, the horse collagen sheet is cut into 1cm 2 square slices.

[0260] 2) Examine samples of these cut pieces under a conventional scanning microscope in order to determine the general morphological consistency and thickness of the material as a reference for the expansion process.

[0261] 3) These cut pieces were then put into plastic Petri dishes.

[0262] 4) Fluid uptake capacity and swelling capacity are then checked by serial titration with physiological saline solution, administered with an Eppendorf micropipette, using gradually increasing amounts of fluid from 10 μl / cm 2 Start up to a maximum of 150 μl / cm 2 (See Table 3).

[0263]

[0264] result:

[0265] The amount of fluid penetrated into the equine collagen sheets was measured after 1, 2 and 3 hours as indicated in the table a...

Embodiment 3

[0270] Example 3 - Increase in length of hydrated equine collagen flakes

[0271] 1.0cm 2 Seven dried equine collagen flakes of the size were placed in isotonic sodium chloride and hydrated for 1 hour. The average increase in length due to hydration of dried equine collagen flakes was approximately 3.4%.

[0272] Table 4

[0273] film number dry length

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Abstract

The present invention is a method of repairing and regenerating mammalian dural tissue using a substantially non-porous sheet of equine collagen when the dural tissue is damaged by injury, tumor, surgery, or the like. The non-porous equine collagen sheet includes collagen fibrils that provide a replacement dura mater composition that is elastic, liquid impermeable, and has high tensile strength. In addition, the non-porous equine collagen sheets are resorbable and provide a biological matrix in which a new dura mater is rapidly formed, which can become indistinguishable from the native dura mater in a matter of weeks. A method for preparing equine collagen sheets that reduces the likelihood of disease transmission.

Description

[0001] A portion of the disclosure of this patent document includes material that is subject to copyright protection. The copyright owner has no objection to the reproduction by anyone of the patent document or the patent disclosure as it appears in the patent file or records of the Patent and Trademark Office, but otherwise All other copyrights reserved. field of invention [0002] The present invention relates to the use of a substantially non-porous collagen flake composition as a graft material to repair and / or regenerate dura mater tissue in a mammal. More particularly, the present invention relates to a collagen flake composition of non-human origin as an alternative Dural material, and use as a biomatrix for dura mater regeneration. Background of the invention [0003] The dura mater is a structure that plays an important role in the anatomy of the central nervous system, forming a membrane system that envelops the entire central nervous system and protects the centr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/24
Inventor J·奥达A·泽佩尔尼亚R·沙赫特勒A·W·施滕伯格
Owner BAXTER INT INC
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